Independencia entre las cuestiones en el análisis factorial de tablas disyuntivas incompletas con preguntas condicionadas

El análisis de correspondencias múltiples (ACM) estudia la relación entre varias variables cualitativas definidas sobre una misma población. Sin embargo, una de las principales fuentes de información son las encuestas donde es frecuente encontrar cierto número de datos ausentes y de preguntas condicionadas. Escofier (Escofier 1981) propone analizar la tabla disyuntiva incompleta sustituyendo la marginal real de la tabla sobre los individuos por una marginal impuesta constante. El análisis de la tabla disyuntiva incompleta está asociado a unas tasas de inercia pequeñas que no deben ser interpretadas como partes de información explicada por los ejes. Se estudiará el caso en el cual las cuestiones son independientes dos a dos y se propondrá una corrección a estas tasas de inercia en el análisis con marginal modificada de una tabla disyuntiva incompleta

Use of Biochar from Rice Husk Pyrolysis: Part A: Recovery as an Adsorbent in the Removal of Emerging Compounds

[EN] One of the main products of pyrolysis is char. For the better performance and improvement of its physicochemical properties, it is necessary to make temperature changes. In this study, different temperatures have been tested for the pyrolysis of rice husk, and the biochar obtained from the process went through an evaluation to test its yield in the removal of emerging compounds such as azithromycin (AZT) and erythromycin (ERY). For this, pyrolysis of rice husk has been carried out at temperatures of 450, 500, 550, and 600 degrees C, and the biochars have been characterized by ultimate analysis and proximate analysis, as well as specific surface area tests. Then, different adsorption tests have been carried out with a 200 mg L-1 drug (AZT and ERY) solution prepared in the laboratory. All biochars have been found to present removal percentages higher than 95%. Therefore, obtaining biochar from rice husk at any temperature and using it in the removal of high-molecular-weight compounds are quite suitable.This work was carried out with financial support from the Department of Civil and Environmental Engineering at Universidad de los Andes. This publication was partially made possible by the call for proposals CI-0120: "Publish your new knowledge or expose your new creations" from the Office Vice President for Research and Creation at Universidad de los Andes

Identification of circulating miRNA profiles that distinguish malignant pleural mesothelioma from lung adenocarcinoma

Accurate diagnosis of malignant pleura mesothelioma (MPM) is challenging. Differential diagnosis of MPM versus lung adenocarcinoma (AD) is particularly difficult, yet clinically important since the two neoplasias call for different treatment approaches. Circulating miRNA-profiling to identify miRNAs that can be used to distinguish MPM from AD has not been reported. We conducted a wide screening study of miRNA profiles in serum pools of MPM patients (N = 11), AD patients (N = 36), and healthy subjects (N = 45) to identify non-invasive biomarkers for differential diagnosis of MPM and AD, using deep sequencing. Sequencing detected up to 300 known miRNAs and up to 25 novel miRNAs species in the serum samples. Among known miRNAs, 7 were upregulated in MPM and 12 were upregulated in AD compared to healthy controls. Of these, eight were distinctive for AD and three were unique for MPM. Direct comparison of the miRNA profiles for MPM and AD revealed differences in miRNA levels that could be useful for differential diagnosis. No differentially expressed novel miRNAs were found. Further bioinformatics analysis indicated that three upregulated miRNAs in MPM are associated with the p38 pathway. There are unique alterations in serum miRNAs in MPM and AD compared to healthy controls, as well as differences between MPM and AD profiles. Differing miRNA levels between MPM and AD may be useful for differential diagnosis. A potential association to p38 pathway of three upregulated miRNAs in MPM was revealed

Use of tocilizumab in kidney transplant recipients with COVID-1

Acute respiratory distress syndrome associated with coronavirus infection is related to a cytokine storm with large interleukin-6 (IL-6) release. The IL-6-receptor blocker tocilizumab may control the aberrant host immune response in patients with coronavirus disease 2019 (COVID-19) . In this pandemic, kidney transplant (KT) recipients are a high-risk population for severe infection and showed poor outcomes. We present a multicenter cohort study of 80 KT patients with severe COVID-19 treated with tocilizumab during hospital admission. High mortality rate was identified (32.5%), related with older age (hazard ratio [HR] 3.12 for those older than 60 years, P = .039). IL-6 and other inflammatory markers, including lactic acid dehydrogenase, ferritin, and D-dimer increased early after tocilizumab administration and their values were higher in nonsurvivors. Instead, C-reactive protein (CRP) levels decreased after tocilizumab, and this decrease positively correlated with survival (mean 12.3 mg/L in survivors vs. 33 mg/L in nonsurvivors). Each mg/L of CRP soon after tocilizumab increased the risk of death by 1% (HR 1.01 [confidence interval 1.004-1.024], P = .003). Although patients who died presented with worse respiratory situation at admission, this was not significantly different at tocilizumab administration and did not have an impact on outcome in the multivariate analysis. Tocilizumab may be effective in controlling cytokine storm in COVID-19 but randomized trials are needed

The Knowledge Management Processes at Different Stages of Group Development

ABSTRACT Based on a developmental approach, this study intended to analyze the extent to which the different stages of group development differ regarding the use of knowledge management processes. The sample comprised 211 teams belonging to a Portuguese military organization. In order to test the hypotheses a multivariate analysis of variance was conducted. The results showed that more mature and cooperative groups (Restructuring/Realization phase) apply to a greater degree the processes of knowledge management, while groups in which there is high intragroup competition and in which members try to “gain power” among themselves (Reframing phase), apply these processes to a lesser degree