164 research outputs found
SafeWeb: A Middleware for Securing Ruby-Based Web Applications
Web applications in many domains such as healthcare and finance must process sensitive data, while complying with legal policies regarding the release of different classes of data to different parties. Currently, software bugs may lead to irreversible disclosure of confidential data in multi-tier web applications. An open challenge is how developers can guarantee these web applications only ever release sensitive data to authorised users without costly, recurring security audits.
Our solution is to provide a trusted middleware that acts as a “safety net” to event-based enterprise web applications by preventing harmful data disclosure before it happens. We describe the design and implementation of SafeWeb, a Ruby-based middleware that associates data with security labels and transparently tracks their propagation at different granularities across a multi-tier web architecture with storage and complex event processing. For efficiency, maintainability and ease-of-use, SafeWeb exploits the dynamic features of the Ruby programming language to achieve label propagation and data flow enforcement. We evaluate SafeWeb by reporting our experience of implementing a web-based cancer treatment application and deploying it as part of the UK National Health Service (NHS)
Anomalous thermal conductivity of NaV2O5 as compared to conventional spin-Peierls system CuGeO3
A huge increase of thermal conductivity k is observed at the phase transition
in stoichiometric NaV2O5. This anomaly decreases and gradually disappears with
deviation from stoichiometry in Na(1-x}V2O5 (x = 0.01, 0.02, 0.03, and 0.04).
This behavior is compared with that of pure and Zn-doped CuGeO3 where only
modest kinks in the k(T) curves are observed at the spin-Peierls transition.
The change of k at critical temperature Tc could be partially attributed to the
opening of an energy gap in the magnetic excitation spectrum excluding the
scattering of thermal phonons on spin fluctuations. However, the reason for
such a strong anomaly in the k(T) may lie not only in the different energy
scales of CuGeO3 and NaV2O5, but also in the different character of the phase
transition in NaV2O5 which can have largely a structural origin, e.g. connected
with the charge ordering.Comment: PostScript 4 pages, 4 PostScript pictures. Submitted to Physical
Review Letter
Intron Dynamics in Ribosomal Protein Genes
The role of spliceosomal introns in eukaryotic genomes remains obscure. A large scale analysis of intron presence/absence patterns in many gene families and species is a necessary step to clarify the role of these introns. In this analysis, we used a maximum likelihood method to reconstruct the evolution of 2,961 introns in a dataset of 76 ribosomal protein genes from 22 eukaryotes and validated the results by a maximum parsimony method. Our results show that the trends of intron gain and loss differed across species in a given kingdom but appeared to be consistent within subphyla. Most subphyla in the dataset diverged around 1 billion years ago, when the “Big Bang” radiation occurred. We speculate that spliceosomal introns may play a role in the explosion of many eukaryotes at the Big Bang radiation
High frequency ESR investigation on dynamical charge disproportionation and spin gap excitation in NaV_2O_5
A significant frequency dependence of the ESR line width is found in NaV_2O_5
between 34-100 K and the line width increases as the resonance frequency is
increased from 95 GHz to 760 GHz. The observed frequency dependence is
qualitatively explained in terms of the dynamical charge disproportionation.
The present results show the essential role of the internal charge degree of
freedom in a V-O-V bond. We have also proposed the existence of the
Dzyaloshinsky-Moriya interaction in the low temperature charge ordered phase
considering the breaking of the selection rule of ESR realized as the direct
observation of the spin gap excitation.Comment: 9 figures submitted to J. Phys.Soc. Jp
Raman Scattering in the Inorganic Spin-Peierls System alpha'-Na_{1-delta}V_2O_5
We have studied the spin-Peierls (SP) transition in alpha'-Na_{1-delta}V_2O_5
(delta = 0, 0.01 and 0.1) by means of Raman scattering. At room temperature, we
observe six A_1 and three A_2 phonon modes and a broad Raman band. Below
T_{SP}several new peaks and a new broad band appear. The new peak at 62 cm^{-1}
originates from the SP-gap excitation. The new peak at 128 cm^{-1} and the new
broad band between 130 and 400 cm^{-1} come from two magnetic excitations. The
new peaks at 102, 646 and 944 cm^{-1} are assigned to the folded phonon modes
and their Na^+-ion deficiency dependence shows that the defect of Na^+ ion
suppresses the SPtransition. The polarized Raman spectra below T_{SP} suggest
that the possible crystal symmetry is C_s^2(Pn) or C_1^1(P1). The asymmetric
lineshape of the 531-cm^{-1} peak superimposed on the electronic Raman band
from the d-d transition around 600 cm^{-1} is interpreted in terms of the Fano
resonance between the electronic continuous band and the phonon with a finite
lifetime. The defects of the Na^+ ions reduce the Fano effect because the life
time of the phonon and the phonon-continuum interaction are decreased.Comment: 24 pages, 10 Postscript figures,uses jpsj.sty and epsf.sty. in press
in J. Phys. Soc. Jp
Can a frustrated spin-cluster model describe the low-temperature physics of NaV_2O_5 ?
Recent experimental evidence suggest the existence of three distinct
V-valence states (V^{+4}, V^{+4.5} and V^{+5}) in the low-temperature phase of
NaV_2O_5 in apparent discrepancy with the observed spin-gap. We investigate a
novel spin cluster model, consisting of weakly coupled, frustrated four-spin
clusters aligned along the crystallographic b-axis that was recently proposed
to reconcile these experimental observations. We have studied the phase diagram
and the magnon dispersion relation of this model using DMRG, exact
diagonalization and a novel cluster-operator theory. We find a spin-gap for all
parameter values and two distinct phases, a cluster phase and a Haldane phase.
We evaluate the size of the gap and the magnon dispersion and find no parameter
regime which would reproduce the experimental results. We conclude that this
model is inappropriate for the low-temperature regime of NaV_2O_5
Spin gap behavior and charge ordering in \alpha^{\prime}-NaV_2O_5 probed by light scattering
We present a detailed analysis of light scattering experiments performed on
the quarter-filled spin ladder compound -NaVO for
the temperature range 5 KT300 K. This system undergoes a phase
transition into a singlet ground state at T=34 K accompanied by the formation
of a super structure. For T34 K several new modes were detected. Three of
these modes are identified as magnetic bound states. Experimental evidence for
charge ordering on the V sites is detected as an anomalous shift and splitting
of a V-O vibration at 422 cm for temperatures above 34 K. The smooth and
crossover-like onset of this ordering at T= 80 K is accompanied by
pretransitional fluctuations both in magnetic and phononic Raman scattering. It
resembles the effect of stripe order on the super structure intensities in
LaNiO.Comment: 36 pages, 11 figures, accepted for publication in PRB (sept.99
Lattice vibrations of alpha'-NaV2O5
We have measured far infrared reflectance and transmittance spectra as well
as Raman scattering spectra of \alpha'-NaV2O5 single crystals for all the
principal polarizations. The temperature range above the phase transition
temperature T_c=35 K was investigated, mainly. On the basis of this
experimental study and of the lattice dynamics calculations we conclude that
the symmetry of NaV2O5 in the high temperature phase is described by the
centrosymmetric D_{2h}^{13} space group. The assignment of the observed phonons
is given. Values of dielectric constants are obtained from the infrared data.
Asymmetric shapes of several infrared lines as well as higher order infrared
vibrational spectra are discussed. The crystal field energy levels of the 3d
electron localized at the V^{4+} site have been calculated in the framework of
the exchange charge model using the values of effective charges obtained from
the lattice dynamics calculations. According to the results of these
calculations, the earlier observed broad optical bands in the region of 1 eV
can be interpreted as phonon assisted d-d transitions.Comment: 12 pages, 8 figures, 5 tables; submitted to PR
Histone demethylase KDM5D drives sex-specific differences in colorectal cancer
View full abstracthttps://openworks.mdanderson.org/leading-edge/1011/thumbnail.jp
Knowledge, experience, and potential risks of dating violence among Japanese university students: a cross-sectional study
<p>Abstract</p> <p>Background</p> <p>The Domestic Violence Prevention Act came into effect in Japan in 2001, but covers only marriage partner violence and post-divorce partner violence, and does not recognize intimate partner violence (IPV). The present study was performed to determine the experience of harassment, both toward and from an intimate partner, and recognition of harassment as IPV among Japanese university students.</p> <p>Methods</p> <p>A self-administered questionnaire survey regarding the experience of harassment involving an intimate partner was conducted as a cross-sectional study among freshman students in a prefectural capital city in Japan.</p> <p>Results</p> <p>A total of 274 students participated in the present study. About half of the subjects (both male and female students) had experience of at least one episode of harassment toward or had been the recipient of harassment from an intimate partner. However, the study participants did not recognize verbal harassment, controlling activities of an intimate partner, and unprotected sexual intercourse as violence. Experience of attending a lecture/seminar about domestic violence and dating violence did not contribute to appropriate help-seeking behavior.</p> <p>Conclusions</p> <p>An educational program regarding harassment and violence prevention and appropriate help-seeking behavior should be provided in early adolescence to avoid IPV among youth.</p
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