A case of effective single-session treatment for attention deficit and learning problems in a routine clinical practice : the value of a transdiagnostic approach to case formulation

This article reports a systematic clinical case study of the psychological assessment and treatment of Daniel (9), a coloured South African boy with a diagnosis of attention deficit hyperactivity disorder (ADHD) (inattentive type). The case is of scientific interest because: (1) there was only a single treatment session, in which contingency management training was delivered to Daniel’s parents and teacher; (2) there was evidence for the effectiveness of the intervention immediately and at two-year follow-up; (3) it documents the transportability to a South African context of an intervention developed by overseas research; (4) it documents the central role of case formulation in the delivery of effective psychological interventions; and (5) although Daniel met the criteria for ADHD, he also displayed symptoms of depression and social anxiety and the case supports the use of a transdiagnostic approach to case formulation. The conscientiousness with which his parents and teachers applied the programme was a major factor in the effectiveness of the intervention, and such rapid impact would not be possible where parents and teachers are unavailable or not co-operative. The publication of systematic case studies such as this one is important for the development of a local evidence-based practice in South Africa

A model of medical reception - the planning and control of multiple task work

This research follows in the Broadbent tradition of constructing a general theory to solve applied problems. The paper reports part of wider research intended to construct a framework for modelling the planning and control of multiple task work. The function of the framework is to support the solution of design problems associated with the performance of interactive planning and control worksystems. The study reported here used an initial version of the framework, based on a study of secretarial office administration, to construct a model of medical reception work. An observational study collected protocol data concerning a medical reception worksystem, comprising two receptionists and various office devices; its domain of application, comprising doctors, patients, their appointments, medical records etc.; and its performance, comprising the quality of medical reception work and the costs to the receptionists of performing that work. The data were then used in conjunction with the planning and control framework to construct the model of medical reception. The model includes physical and abstract structures and behaviours of the medical reception worksystem, as well as physical and abstract objects of its domain of application. Of particular interest for the solution of design problems is the model's differentiation of plan types into task plans, procedure plans, and activity plans. These plan types were used to extend the framework for the planning and control of multiple task work. The paper concludes with a brief illustration of how the model of medical reception might be used to support the solution of interactive worksystem design problems as they relate to performance. Future work to develop further the framework of planning and control of multiple task work and its application are discussed

The robustness of interdependent clustered networks

It was recently found that cascading failures can cause the abrupt breakdown of a system of interdependent networks. Using the percolation method developed for single clustered networks by Newman [Phys. Rev. Lett. {\bf 103}, 058701 (2009)], we develop an analytical method for studying how clustering within the networks of a system of interdependent networks affects the system's robustness. We find that clustering significantly increases the vulnerability of the system, which is represented by the increased value of the percolation threshold $p_c$ in interdependent networks.Comment: 6 pages, 6 figure

Risking Communications Security: Potential Hazards of the Protect America Act

A new US law allows warrantless wiretapping whenever one end of the communication is believed to be outside national borders. This creates serious security risks: danger of exploitation of the system by unauthorized users, danger of criminal misuse by trusted insiders, and danger of misuse by government agents

Framework for engineering of spin defects in hexagonal boron nitride by focused ion beams

Hexagonal boron nitride (hBN) is gaining interest as a wide bandgap van der Waals host of optically active spin defects for quantum technologies. Most studies of the spin-photon interface in hBN focus on the negatively charged boron vacancy (VB-) defect, which is typically fabricated by ion irradiation. However, VB- fabrication methods often lack robustness and reproducibility when applied to thin flakes (less than 10 nm) of hBN. Here we identify mechanisms that both promote and inhibit VB- generation and optimize ion beam parameters for site-specific fabrication of optically active VB- centers. We emphasize conditions accessible by high resolution focused ion beam (FIB) systems, and present a framework for VB- fabrication in hBN flakes of arbitrary thickness for applications in quantum sensing and quantum information processing.Comment: 11 pages, 5 figure

Planning for multiple task work: an analysis of a medical reception worksystem

This paper presents an investigation of interactive worksystem planning in the multiple task work domain of medical reception. In an observational study of a medical reception worksystem, three different types of plan were identified: the task plan, the procedure plan and the activity plan. These three types of plan were required for effective working in the domain of medical reception, because of the many similar concurrent tasks, the frequency of behaviour switching between tasks and the need for consistency within the worksystem. It is proposed, therefore, that to design effective interactive human-computer worksystems for the domain of medical reception (and possibly for other work domains of a similar nature), the designer must specify the three different types of plan and the relationships between them. The three types of plan in medical reception are discussed in the context of design issues such as the allocation of planning structures

Theory of Spin-Resolved Auger-Electron Spectroscopy from Ferromagnetic 3d-Transition Metals

CVV Auger electron spectra are calculated for a multi-band Hubbard model including correlations among the valence electrons as well as correlations between core and valence electrons. The interest is focused on the ferromagnetic 3d-transition metals. The Auger line shape is calculated from a three-particle Green function. A realistic one-particle input is taken from tight-binding band-structure calculations. Within a diagrammatic approach we can distinguish between the \textit{direct} correlations among those electrons participating in the Auger process and the \textit{indirect} correlations in the rest system. The indirect correlations are treated within second-order perturbation theory for the self-energy. The direct correlations are treated using the valence-valence ladder approximation and the first-order perturbation theory with respect to valence-valence and core-valence interactions. The theory is evaluated numerically for ferromagnetic Ni. We discuss the spin-resolved quasi-particle band structure and the Auger spectra and investigate the influence of the core hole.Comment: LaTeX, 12 pages, 8 eps figures included, Phys. Rev. B (in press

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Summary Tissue homeostasis requires maintenance of functional integrity under stress. A central source of stress is mechanical force that acts on cells, their nuclei, and chromatin, but how the genome is protected against mechanical stress is unclear. We show that mechanical stretch deforms the nucleus, which cells initially counteract via a calcium-dependent nuclear softening driven by loss of H3K9me3-marked heterochromatin. The resulting changes in chromatin rheology and architecture are required to insulate genetic material from mechanical force. Failure to mount this nuclear mechanoresponse results in DNA damage. Persistent, high-amplitude stretch induces supracellular alignment of tissue to redistribute mechanical energy before it reaches the nucleus. This tissue-scale mechanoadaptation functions through a separate pathway mediated by cell-cell contacts and allows cells/tissues to switch off nuclear mechanotransduction to restore initial chromatin state. Our work identifies an unconventional role of chromatin in altering its own mechanical state to maintain genome integrity in response to deformation.Peer reviewe

Observation of Stratospheric Ozone Depletion associated with Delta II Rocket Emissions

Ozone, chlorine monoxide, methane, and submicron particulate concentrations were measured in the stratospheric plume wake of a Delta II rocket powered by a combination of solid (NH4ClO4/Al) and liquid (LOX/kerosene) propulsion systems. We apply a simple kinetics model describing the main features of gas-phase chlorine reactions in solid propellant exhaust plumes to derive the abundance of total reactive chlorine in the plume and estimate the associated cumulative ozone loss. Measured ozone loss during two plume encounters (12 and 39 minutes after launch) exceeded the estimate by about a factor of about two. Insofar as only the most significant gas-phase chlorine reactions are included in the calculation, these results suggest that additional plume wake chemical processes or emissions other than reactive chlorine from the Delta II propulsion system affect ozone levels in the plume