Property Interests in Cadaverous Organs: Changes to Ohio Anatomical Gift Law and the Erosion of Family Rights

This note examines how Ohio anatomical gift laws have been interpreted to grant a property right to the next of kin in the decedent’s cadaverous organs. Part II of this note briefly examines the origins of anatomical gift law in the United States and in Ohio. Part III examines the codification of Ohio common law and the adoption of the 1969 Uniform Anatomical Gift Act as the foundation of Ohio’s anatomical gift laws. Part IV analyzes post 1969 Ohio cases that directly or indirectly help interpret Ohio’s anatomical gift laws, with a particular focus on the legal reasoning in Brotherton II. Part V delves into the new law’s grant of property rights in cadaverous organs to the donee and criticizes the new law because of administrative and public relations problems such changes could create. Part VII proposes a legislative alternative recommending statutory recognition of the next of kin’s property rights in cadaverous organs

Association between depressive symptom clusters and food attentional bias

Background The mechanisms underlying the depression-obesity relationship are unclear. Food attentional bias (FAB) represents one candidate mechanism that has not been examined. We evaluated the hypothesis that greater depressive symptoms are associated with increased FAB. Method Participants were 89 normal weight or overweight adults (mean age = 21.2 ± 4.0 years, 53% female, 33% non-white, mean body mass index in kg/m2 = 21.9 ± 1.8 for normal weight; 27.2 ± 1.5 for overweight). Total, somatic, and cognitive-affective depressive symptom scores were computed from the Patient Health Questionnaire-8 (PHQ-8). FAB scores were calculated using reaction times (RT) and eye-tracking (ET) direction and duration measures for a food visual probe task. Age, gender, race/ethnicity, and body fat percent were covariates. Results Only PHQ-8 somatic symptoms were positively associated with RT-measured FAB (β = 0.23, p = .04). The relationship between somatic symptoms and ET direction (β = 0.18, p = .17) and duration (β = 0.23, p = .08) FAB indices were of similar magnitude but were not significant. Somatic symptoms accounted for 5% of the variance in RT-measured FAB. PHQ-8 total and cognitive-affective symptoms were unrelated to all FAB indices (ps ≥ 0.09). Conclusions Only greater somatic symptoms of depression were linked to food attentional bias as measured using reaction time. Well-powered prospective studies should examine whether this bias replicates, particularly for eye-tracking measures, and whether it partially mediates the depression-to-obesity relationship

Diminishing Use of Liver Biopsy among Liver Transplant Recipients for Hepatitis C.

Background and Aims: Hepatitis C virus (HCV) cirrhosis is the leading indication for liver transplantation in the United States and recurrent HCV following liver transplantation is a major cause of allograft loss and mortality. Liver biopsies are commonly used to identify recurrent HCV and determine the need for antiviral therapy. The introduction of direct-acting antiviral agents (DAAs) has changed the management of recurrent HCV infection. This study aimed to describe the role of liver biopsies in liver transplant recipients with HCV after the introduction of DAAs. Methods: A retrospective analysis was performed looking at the rate of liver biopsies post-liver transplantation for HCV. The analysis included 475 adult liver transplants for hepatitis C performed at the University of California, Los Angeles from January 1, 2006 to October 1, 2015. Patients were divided into two eras, pre- and post-introduction of DAAs on December 1, 2013. Results: In the era before the introduction of DAAs, the percentage of patients biopsied was significantly higher compared to the era after the introduction of DAAs (56.1% vs. 26.9%, p < 0.001). Conclusions: The introduction of DAAs has changed the management of liver biopsy following liver transplantation and the management of recurrent HCV. Given that DAAs are well tolerated and have high efficacy, liver biopsies are no longer routinely used to justify the use antiviral therapy following liver transplantation

Weight discrimination: Are colleges preparing their graduates for successful employment and careers?

Background: Colleges are uniquely positioned to influence both the short and long-term health and well-being of students through implementation of interventions to prevent and/or treat obesity among students; and have a vested interest given obesity has the potential to impact students' matriculation, graduation, and career prospects.Aim: To illustrate the essential roles of colleges to influence obesity prevention and treatment given the potential to influence the students' matriculation, graduation, and career prospects.Methods: The discussion begins with an overview of the prevalence and societal implications of obesity. Next the implications for higher education with respect to matriculation and graduation, the influence of higher education on lifestyle behaviors, and the influence of obesity on academic performance. This is followed by the influence of obesity on students' post-higher education lives, including potential discrimination when seeking employment, and the impact that the nature of the jobs that graduates attain may have on their health and well-being.Results: There exists a great need to reduce the prevalence of obesity and colleges are well positioned to provide leadership and direction.Conclusions: Implications for colleges are set forth, with ways in which they can play a role in promoting student health detailed

Longitudinal Monitoring of SARS-CoV-2 IgM and IgG Seropositivity to Detect COVID-19.

BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a novel beta-coronavirus that has recently emerged as the cause of the 2019 coronavirus pandemic (COVID-19). Polymerase chain reaction (PCR) based tests are optimal and recommended for the diagnosis of an acute SARS-CoV-2 infection. Serology tests for viral antibodies provide an important tool to diagnose previous exposure to the virus. Here we evaluate the analytical performance parameters of the Diazyme SARS-CoV-2 IgM/IgG serology assays and describe the kinetics of IgM and IgG seroconversion observed in patients with PCR-confirmed COVID-19 who were admitted to our hospital.MethodsWe validated the performance of the Diazyme assay in 235 presumed SARS-CoV-2 negative subjects to determine specificity. Subsequently, we evaluated the SARS-CoV-2 IgM and IgG seroconversion of 54 PCR-confirmed COVID-19 patients and determined sensitivity of the assay at three different timeframes.ResultSensitivity and specificity for detecting seropositivity at ≥15 days following a positive SARS-CoV-2 PCR result, was 100.0% and 98.7% when assaying for the panel of IgM and IgG. The median time to seropositivity observed for a reactive IgM and IgG result from the date of a positive PCR was 5 days (IQR: 2.75-9 days) and 4 days (IQR: 2.75-6.75 days), respectively.ConclusionsOur data demonstrate that the Diazyme IgM/IgG assays are suited for the purpose of detecting SARS-CoV-2 IgG and IgM in patients with suspected SARS-CoV-2 infections. For the first time, we report longitudinal data showing the evolution of seroconversion for both IgG and IgM in a cohort of acutely ill patients in the United States. We also demonstrate a low false positive rate in patients who were presumed to be disease free

Case History Illustrating the Challenges of Foundation Design and Construction in Karst Terrain

This paper discusses the challenges associated with design and construction of foundation systems for a Corporate Campus located in Chester County, Pennsylvania that is underlain by Karst terrain. A comprehensive subsurface investigation was implemented to develop adequate foundation systems and related site work precautions. Because there was evidence of sinkhole activity prior to any construction work, and the subsoils revealed some variability from a consistency/density standpoint, the selected foundation system design included a combination of soil improvement using compaction grouting for shallow foundations and deep drilled-pier foundations. After construction activities began, several occurrences of solution activity were documented and repaired. During construction of drilled-pier foundations at one of the structure locations, a significant number of voids and discontinuities in the rock were encountered. The impact of these discontinuities and voids was dramatic to the effort and time necessary to complete the drilled pier foundation construction for this structure. After careful consideration of potential cost and schedule impacts, the foundation design for remaining structures was modified to eliminate the use of drilled piers and incorporated only compaction grouting for support of shallow foundation systems. Interaction of the Geotechnical Engineer, Construction Manager, Owner, and Contractor began early in the construction process and this interaction became critical to the project success as work proceeded on this project

Assessing the association between oral hygiene and preterm birth by quantitative light-induced fluorescence

The aim of this study was to investigate the purported link between oral hygiene and preterm birth by using image analysis tools to quantify dental plaque biofilm. Volunteers (η = 91) attending an antenatal clinic were identified as those considered to be “at high risk” of preterm delivery (i.e., a previous history of idiopathic preterm delivery, case group) or those who were not considered to be at risk (control group). The women had images of their anterior teeth captured using quantitative light-induced fluorescence (QLF). These images were analysed to calculate the amount of red fluorescent plaque (ΔR%) and percentage of plaque coverage. QLF showed little difference in ΔR% between the two groups, 65.00% case versus 68.70% control, whereas there was 19.29% difference with regard to the mean plaque coverage, 25.50% case versus 20.58% control. A logistic regression model showed a significant association between plaque coverage and case/control status (Ρ = 0.031), controlling for other potential predictor variables, namely, smoking status, maternal age, and body mass index (BMI)

Pelagic Sargassum Mediates Predation Among Symbiotic Fishes and Shrimps

We investigated, using microcosm experiments, predator-prey relationships of symbionts within sargassum communities. Specifically, two predatory fishes (Stephanolepis hispidus and Histrio histrio) and two shrimp species (Latreutes fucorum and Leander tennicornis) were studied. The following research questions were addressed: 1) Do the fish predators select preferentially particular shrimp prey species? and 2) Does available habitat affect survival times of shrimp prey, or prey selection by fish predators? Stephanolepis hispidus showed a selection preference for Latreutes fucorum, as this shrimp\u27s survival times were significantly lower than for Leander tennicornis in predation trials. However, H. histrio did not show a preference for either shrimp species, as survival times for shrimp did not differ significantly. Differences observed in these selection patterns are likely related to 1) differences in the foraging strategies of the predators and 2) prey defenses (morphological). A comparison of survival times with and without sargassum habitat (both natural and synthetic) demonstrates clearly that both shrimp species ultimately receive some degree of protection from these fish predators by living in these morphologically complex communities