Prenatal Serum Concentrations of Brominated Flame Retardants and Autism Spectrum Disorder and Intellectual Disability in the Early Markers of Autism Study: A Population-Based Case-Control Study in California.

BackgroundPrior studies suggest neurodevelopmental impacts of polybrominated diphenyl ethers (PBDEs), but few have examined diagnosed developmental disorders.ObjectivesOur aim was to determine whether prenatal exposure to brominated flame retardants (BFRs) is associated with autism spectrum disorder (ASD) or intellectual disability without autism (ID).MethodsWe conducted a population-based case-control study including children with ASD (n=545) and ID (n=181) identified from the California Department of Developmental Services and general population (GP) controls (n=418) from state birth certificates. ASD cases were matched to controls by sex, birth month, and birth year. Concentrations of 10 BFRs were measured in maternal second trimester serum samples stored from routine screening. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses.ResultsGeometric mean concentrations of five of the six congeners with ≥55% of samples above the limit of detection were lower in mothers of children with ASD or ID than in controls. In adjusted analyses, inverse associations with several congeners were found for ASD relative to GP (e.g., quartile 4 vs. 1, BDE-153: AOR=0.56, 95% CI: 0.38, 0.84). When stratified by child sex (including 99 females with ASD, 77 with ID, and 73 with GP), estimates were consistent with overall analyses in boys, but in the opposite direction among girls, particularly for BDE-28 and -47 (AOR=2.58, 95% CI: 0.86, 7.79 and AOR=2.64, 95% CI: 0.97, 7.19, respectively). Similar patterns overall and by sex were observed for ID.ConclusionsContrary to expectation, higher PBDE concentrations were associated with decreased odds of ASD and ID, though not in girls. These findings require confirmation but suggest potential sexual dimorphism in associations with prenatal exposure to BFRs. https://doi.org/10.1289/EHP1079

New statistical RI index allow to better track the dynamics of COVID-19 outbreak in Italy

COVID-19 pandemic in Italy displayed a spatial distribution that made the tracking of its time course quite difficult. The most relevant anomaly was the marked spatial heterogeneity of COVID-19 diffusion. Lombardia region accounted for around 60% of fatal cases (while hosting 15% of Italian population). Moreover, 86% of fatalities concentrated in four Northern Italy regions. The ‘explosive’ outbreak of COVID-19 in Lombardia at the very beginning of pandemic fatally biased the R-like statistics routinely used to control the disease dynamics. To (at least partially) overcome this bias, we propose a new index RI = dH/dI (daily derivative ratio of H and I, given H = Healed and I = Infected), corresponding to the ratio between healed and infected patients relative daily changes. The proposed index is less flawed than R by the uncertainty related to the estimated number of infected persons and allows to follow (and possibly forecast) epidemic dynamics in a largely model-independent way. To analyze the dynamics of the epidemic, starting from the beginning of the virus spreading—when data are insufficient to make an estimate by adopting SIR model—a "sigmoidal family with delay" logistic model was introduced. That approach allowed in estimating the epidemic peak using the few data gathered even before mid-March. Based on this analysis, the peak was correctly predicted to occur by end of April. Analytical methodology of the dynamics of the epidemic we are proposing herein aims to forecast the time and intensity of the epidemic peak (forward prediction), while allowing identifying the (more likely) beginning of the epidemic (backward prediction). In addition, we established a relationship between hospitalization in intensive care units (ICU) versus deaths daily rates by avoiding the necessity to rely on precise estimates of the infected fraction of the population The joint evolution of the above parameters over time allows for a trustworthy and unbiased estimation of the dynamics of the epidemic, allowing us to clearly detect the qualitatively different character of the ‘so-called’ second wave with respect to the previous epidemic peak

Catching geomorphological response to volcanic activity on steep slope volcanoes using multi-platform remote sensing

The geomorphological evolution of the volcanic Island of Stromboli (Italy) between July 2010 and June 2019 has been reconstructed by using multi-temporal, multi-platform remote sensing data. Digital elevation models (DEMs) from PLÉIADES-1 tri-stereo images and from Light Detection and Ranging (LiDAR) acquisitions allowed for topographic changes estimation. Data were comprised of high-spatial-resolution (QUICKBIRD) and moderate spatial resolution (SENTINEL-2) satellite images that allowed for the mapping of areas that were affected by major lithological and morphological changes. PLÉIADES tri-stereo and LiDAR DEMs have been quantitatively and qualitatively compared and, although there are artefacts in the smaller structures (e.g., ridges and valleys), there is still a clear consistency between the two DEMs for the larger structures (as the main valleys and ridges). The period between July 2010 and May 2012 showed only minor changes consisting of volcanoclastic sedimentation and some overflows outside the crater. Otherwise, between May 2012 and May 2017, large topographic changes occurred that were related to the emplacement of the 2014 lava flow in the NE part of the Sciara del Fuoco and to the accumulation of a volcaniclastic wedge in the central part of the Sciara del Fuoco. Between 2017 and 2019, minor changes were again detected due to small accumulation next to the crater terrace and the erosion in lower Sciara del Fuoco.Publishedid 4385V. Processi eruttivi e post-eruttiviJCR Journa

Cross-genetic determination of maternal and neonatal immune mediators during pregnancy.

BACKGROUND:The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to autoimmune and neurodevelopmental conditions in later life. Evidence suggests that the immune system in adults not only responds to environmental stimulation but is also under strong genetic control. METHODS:This is the first genetic study of > 700 mother-infant pairs to analyse the circulating levels of 22 maternal mid-gestational serum-derived and 42 neonatal bloodspot-derived immune mediators (cytokines/chemokines) in the context of maternal and fetal genotype. We first estimated the maternal and fetal genome-wide SNP-based heritability (h2g) for each immune molecule and then performed genome-wide association studies (GWAS) to identify specific loci contributing to individual immune mediators. Finally, we assessed the relationship between genetic immune determinants and ASD outcome. RESULTS:We show maternal and neonatal cytokines/chemokines displaying genetic regulation using independent methodologies. We demonstrate that novel fetal loci for immune function independently affect the physiological levels of maternal immune mediators and vice versa. The cross-associated loci are in distinct genomic regions compared with individual-specific immune mediator loci. Finally, we observed an interaction between increased IL-8 levels at birth, autism spectrum disorder (ASD) status, and a specific maternal genotype. CONCLUSIONS:Our results suggest that maternal and fetal genetic variation influences the immune system during pregnancy and at birth via distinct mechanisms and that a better understanding of immune factor determinants in early development may shed light on risk factors for developmental disorders

Relative seismic and tsunami risk assessment for Stromboli Island (Italy)

An innovative method of estimating the relative risk of buildings exposed to seismic and tsunami hazards in volcanic islands is applied to Stromboli (Italy), a well-known stratovolcano affected by moderate earthquakes and mass-flow-induced tsunamis. The method uses a pre-existing quali-quantitative analysis to assess the relative risk indices of buildings, which provide comparative results useful for prioritisation purposes, in combination with a historical-geographical settlement analysis consistent with the ‘territorialist’ approach to the urban and regional planning and design. The quali-quantitative analysis is based on a new proposed survey-sheet model, useful to collect building information necessary for the relative risk estimation, whereas the historical-geographical investigation is based on the multi-temporal comparison of aerial and satellite images. The proposal to combine two consolidated methods represents an innovation in estimating relative risk. Considering that Stromboli Island had never been subjected to similar analyses, the results of the relative seismic risk assessment are novel and moreover identify buildings with a fairly-low and spatially-uniform relative risk. The results of the relative tsunami risk assessment are consistent with results of similar past studies, identifying buildings with a higher relative risk index on the northern coast of the island. The combined use of a building-by-building survey with a multi-temporal analysis of settlements allows obtaining a higher detail than previously available for the region. If adequately modified, the proposed combination of methods allows assessing relative risk also considering other geo-environmental hazards and their cascading effects, in a multi-hazard risk assessment perspective

Variable magnitude and intensity of strombolian explosions: Focus on the eruptive processes for a first classification scheme for Stromboli volcano (Italy)

Strombolian activity varies in magnitude and intensity and may evolve into a threat for the local populations living on volcanoes with persistent or semi-persistent activity. A key example comes from the activity of Stromboli volcano (Italy). The “ordinary” Strombolian activity, consisting in intermittent ejection of bombs and lapilli around the eruptive vents, is sometimes interrupted by high-energy explosive events (locally called major or paroxysmal explosions), which can affect very large areas. Recently, the 3 July 2019 explosive paroxysm at Stromboli volcano caused serious concerns in the local population and media, having killed one tourist while hiking on the volcano. Major explosions, albeit not endangering inhabited areas, often produce a fallout of bombs and lapilli in zones frequented by tourists. Despite this, the classification of Strombolian explosions on the basis of their intensity derives from measurements that are not always replicable (i.e., field surveys). Hence the need for a fast, objective and quantitative classification of explosive activity. Here, we use images of the monitoring camera network, seismicity and ground deformation data, to characterize and distinguish paroxysms, impacting the whole island, from major explosions, that affect the summit of the volcano above 500 m elevation, and from the persistent, mild explosive activity that normally has no impact on the local population. This analysis comprises 12 explosive events occurring at Stromboli after 25 June 2019 and is updated to 6 December 2020

Use of PSInSAR data to map highly compressible soil layers

A new approach to the use of Persistent Scatterers (PS) Interferometry data in the reconstruction of the extension of compressible geological bodies is presented. The methodology was applied in the test area of the Tiber River delta (Italy), characterized by the presence of two large marshy zones, known as the Maccarese and Ostia Antica ponds. PSInSARâ\u84¢ data, derived from ERS1/2, ENVISAT and RADARSAT-1 images, and spanning a time interval between 1992 and 2006 were used to verify the possibility to reconstruct the spatial distribution of the peat levels inside the Maccarese and Ostia Antica ponds. Borehole information was analyzed to calibrate the InSAR data and the deformation rates were used to hypothesize the presence of a thick compressible layer where geological information is lacking. Variations in deformation rates registered by the single PS were assumed to be representative of a variation in the stratigraphic asset. The obtained results demonstrate that this approach could be satisfactorily used to investigate wide areas in a short time, reducing the number of boreholes to drill, and it could be a complementary technique to obtain information about the 2D geometry of specific geological levels

Tracking morphological changes and slope instability using spaceborne and ground-based SAR data

Stromboli (Aeolian Archipelago, Italy) is an active volcano that is frequently affected by moderate to large mass wasting, which has occasionally triggered tsunamis. With the aim of understanding the relationship between the geomorphologic evolution and slope instability of Stromboli, remote sensing information from space-born Synthetic Aperture Radar (SAR) change detection and interferometry (InSAR) and Ground Based InSAR (GBInSAR) was compared with field observations and morphological analyses. Ground reflectivity and SqueeSAR⢠(an InSAR algorithm for surface deformation monitoring) displacement measurements from X-band COSMO-SkyMed satellites (CSK) were analysed together with displacement measurements from a permanent-sited, Ku-band GBInSAR system. Remote sensing results were compared with a preliminary morphological analysis of the Sciara del Fuoco (SdF) steep volcanic flank, which was carried out using a high-resolution Digital Elevation Model (DEM). Finally, field observations, supported by infrared thermographic surveys (IRT), allowed the interpretation and validation of remote sensing data. The analysis of the entire dataset (collected between January 2010 and December 2014) covers a period characterized by a low intensity of Strombolian activity. This period was punctuated by the occurrence of lava overflows, occurring from the crater terrace evolving downslope toward SdF, and flank eruptions, such as the 2014 event. The amplitude of the CSK images collected between February 22nd, 2010, and December 18th, 2014, highlights that during periods characterized by low-intensity Strombolian activity, the production of materials ejected from the crater terrace towards the SdF is generally low, and erosion is the prevailing process mainly affecting the central sector of the SdF. CSK-SqueeSAR⢠and GBInSAR data allowed the identification of low displacements in the SdF, except for high displacement rates (up to 1.5 mm/h) that were measured following both lava delta formation after the 2007 eruption and the lava overflows of 2010 and 2011. After the emplacement of the 2014 lava field, high displacements in the central and northern portions of the SdF were recorded by the GBInSAR device, whereas the spaceborne data were unable to detect these rapid movements. A comparison between IRT images and GBInSAR-derived displacement maps acquired during the same time interval revealed that the observed displacements along the SdF were related to the crumbling of newly emplaced 2014 lava and of its external breccia. Detected slope instability after the 2014 flank eruption was related to lava accumulation on the SdF and to the difference in the material underlying the 2014 lava flow: i) lava flows and breccia layers related to the 2002â03 and 2007 lava flow fields in the northern SdF sector and ii) loose volcaniclastic deposits in the central part of the SdF. This work emphasizes the importance of smart integration of spaceborne, SAR-derived hazard information with permanent-sited, operational monitoring by GBInSAR devices to detect areas impacted by mass wasting and volcanic activity