PCNA and Ki-67 in endometrial hyperplasias and evaluation of the potential of malignancy

WOS: 000286914800015PubMed ID: 21446331Objective: The aim of this study was to investigate malignancy potential in endometrial hyperplasias and association with PCNA and Ki-67. Methods: Hysterectomy or probe curettage materials of 62 patients (20 simple hyperplasias (SH), six SH with atypical changes, five complex hyperplasias (CH), 11 CH with atypical changes, ten proliferative endometrium (PE) and ten secretory endometrium) were included in our study. Immunohistochemical staining for PCNA and Ki-67 protein was performed on formalin-fixed and paraffin-embedded tissue samples. Results: Immunoreactivity of PCNA was found to be significantly higher in atypical CH as compared to all other groups (p < 0.05). Also immunoreactivity of PCNA was significantly lower in SH as compared to atypical CH, and PE (p < 0.05). Average values showed that Ki-67 immunoreactivity is highest for atypical CH, and PE. Immunoreactivity of Ki-67 was found to be significantly higher in atypical CH as compared to other groups except PE (p < 0.05). Conclusion: PCNA immunoreactivity can be useful in patients with endometrial CH showing mild or moderate atypical changes in terms of prefering more conservative treatment modalities in those with low PCNA index. Also we suggest that Ki-67 could be insufficient to determine the potential of malignanc

Sternal osteomyelitis associated with bacillus Calmette-Guérin Moscow strain

PubMed ID: 25799191[No abstract available

A current analysis of caregivers&#039; approaches to fever and antipyretic usage

Introduction: The aim of this survey was to investigate the current knowledge, attitudes, and practices of febrile children&#039;s caregivers about fever, antipyretic usage, and temperature measurement methods in a tertiary care hospital. Methodology: A 41-item questionnaire was administered to a convenience sample of febrile children&#039;s caregivers in face-to-face interviews by two research assistants from January 2012 through June 2012 in an urban region of Turkey. Results: A total of 1,032 caregivers completed the interview. Approximately one-third of caregivers considered a temperature of less than 37.8 degrees C (100 degrees F) to be a fever, and 13% of all respondents would give antipyretics for a body temperature &lt;= 37.8 degrees C. Furthermore, 76% of parents would wake their children from sleep to administer antipyretics. Although a high proportion (89.5%) of respondents believed that fever had harmful effects, 10.5% considered fever to be beneficial. Alternating use of acetaminophen and ibuprofen (44%) and giving antipyretics routinely (71%) before and after immunizations were common parental practices and generally advised by pediatricians. Parents with higher levels of education were more likely to consider fever to be beneficial and to treat fever with antipyretics, and less likely to seek medical attention for mild fever. Most caregivers stated that they were unsure about the right site (90%) and thermometer type (95%) for temperature measurement. Conclusions: Persistent fever anxiety and excessive antipyretic usage may be heightened by the lack of knowledge regarding accurate temperature measurement methods with digital thermometers in our population. Parental education may positively affect the approach to fever and antipyretic usage

Parental vaccine knowledge and behaviours: A survey of Turkish families

Personal and herd immunity require durability in high vaccination coverage rates, and this mainly depends on the interaction between parental and service/provider factors

Multicenter Investigation Of Bufavirus In The Etiology Of Viral Central Nervous System Infections Of Adults And Children | Bufavirusun Çocuklar Ve Erişkinlerdeki Viral Santral Sinir Sistemi Enfeksiyonlarinin Etiyolojisi Açisindan Çok Merkezli Olarak Araştirilmasi

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