268 research outputs found
Parameter identifiability in a class of random graph mixture models
We prove identifiability of parameters for a broad class of random graph
mixture models. These models are characterized by a partition of the set of
graph nodes into latent (unobservable) groups. The connectivities between nodes
are independent random variables when conditioned on the groups of the nodes
being connected. In the binary random graph case, in which edges are either
present or absent, these models are known as stochastic blockmodels and have
been widely used in the social sciences and, more recently, in biology. Their
generalizations to weighted random graphs, either in parametric or
non-parametric form, are also of interest in many areas. Despite a broad range
of applications, the parameter identifiability issue for such models is
involved, and previously has only been touched upon in the literature. We give
here a thorough investigation of this problem. Our work also has consequences
for parameter estimation. In particular, the estimation procedure proposed by
Frank and Harary for binary affiliation models is revisited in this article
Transparency in qualitative research: An overview of key findings and implications of the deliberations
Population normative data for the 10/66 Dementia Research Group cognitive test battery from Latin America, India and China: a cross-sectional survey
Background: 1) To report site-specific normative values by age, sex and educational level for four components of the 10/66 Dementia Research Group cognitive test battery; 2) to estimate the main and interactive effects of age, sex, and educational level by site; and 3) to investigate the effect of site by region and by rural or urban location. Methods: Population-based cross-sectional one phase catchment area surveys were conducted in Cuba, Dominican Republic, Venezuela, Peru, Mexico, China and India. The protocol included the administration of the Community Screening Instrument for Dementia (CSI 'D', generating the COGSCORE measure of global function), and the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) verbal fluency (VF), word list memory (WLM, immediate recall) and recall (WLR, delayed recall) tests. Only those free of dementia were included in the analysis. Results: Older people, and those with less education performed worse on all four tests. The effect of sex was much smaller and less consistent. There was a considerable effect of site after accounting for compositional differences in age, education and sex. Much of this was accounted for by the effect of region with Chinese participants performing better, and Indian participants worse, than those from Latin America. The effect of region was more prominent for VF and WLM than for COGSCORE and WLR. Conclusion: Cognitive assessment is a basic element for dementia diagnosis. Age- and education-specific norms are required for this purpose, while the effect of gender can probably be ignored. The basis of cultural effects is poorly understood, but our findings serve to emphasise that normative data may not be safely generalised from one population to another with quite different characteristics. The minimal effects of region on COGSCORE and WLR are reassuring with respect to the cross-cultural validity of the 10/66 dementia diagnosis, which uses only these elements of the 10/66 battery.Clinical NeurologySCI(E)SSCI17ARTICLEnull
The clinical and molecular genetic approach to Duchenne and Becker muscular dystrophy: an updated protocol
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