Standard Chartered Bank: Women on Corporate Boards in India 2010

This first Standard Chartered Bank: Women on Corporate Boards in India 2010 report looks at the representation of women on the boards of India's leading companies on the Bombay Stock Exchange (BSE-100) . It ranks the companies in terms of the gender diversity of their boards, with those with the highest percentage of women on their boards appearing at the top. The report also examines the general topic of gender diversity on the boards of the BSE-100 by presenting the findings of interviews with 18 female directors of BSE-100 companies

A simple modification of the A. nidulans transformation protocol increases the transformation frequency

After transformation of Aspergillus nidulans with plasmid DNA the transformants are usually incubated at 37C until transformants appear. We have found that pre-incubation of the transformation plates at room temperature for 24h leads to increased transformation frequencies

Highly conductive Sb-doped layers in strained Si

The ability to create stable, highly conductive ultrashallow doped regions is a key requirement for future silicon-based devices. It is shown that biaxial tensile strain reduces the sheet resistance of highly doped n-type layers created by Sb or As implantation. The improvement is stronger with Sb, leading to a reversal in the relative doping efficiency of these n-type impurities. For Sb, the primary effect is a strong enhancement of activation as a function of tensile strain. At low processing temperatures, 0.7% strain more than doubles Sb activation, while enabling the formation of stable, ~10-nm-deep junctions. This makes Sb an interesting alternative to As for ultrashallow junctions in strain-engineered complementary metal-oxide-semiconductor device

Negative Regulation of C/EBPbeta1 by Sumoylation in Breast Cancer Cells

Sumoylation is a post-translational modification that is oftentimes deregulated in diseases such as cancer. Transcription factors are frequent targets of sumoylation and modification by SUMO can affect subcellular localization, transcriptional activity, and stability of the target protein. C/EBPbeta1 is one such transcription factor that is modified by SUMO-2/3. Non-sumoylated C/EBPbeta1, p52-C/EBPbeta1, is expressed in normal mammary epithelial cells but not breast cancer cell lines and plays a role in oncogene-induced senescence, a tumor suppressive mechanism. Although p52-C/EBPbeta1 is not observed via immunoblot in breast cancer cell lines, higher molecular weight bands are observed when breast cancer cell lines are subjected to immunoblot analysis with a C/EBPbeta1-specific antibody. We show that exogenously expressed C/EBPbeta1 is sumoylated in breast cancer cells, and that the higher molecular weight bands we observe in anti-C/EBPbeta1 immunoblots of breast cancer cell lines is sumoylated C/EBPbeta1. Phosphorylation oftentimes enhances sumoylation, and phosphorylation cascades are activated in breast cancer cells. We demonstrate that phosphorylation of C/EBPbeta1Thr235 by Erk-2 enhances sumoylation of C/EBPbeta1 in vitro. In addition, sumoylated C/EBPbeta1 is phosphorylated on Thr235 and mutation of Thr235 to alanine leads to a decrease in sumoylation of C/EBPbeta1. Finally, using a C/EBPbeta1-SUMO fusion protein we show that constitutive sumoylation of C/EBPbeta1 completely blocks its capability to induce senescence in WI38 fibroblasts expressing hTERT. Thus, sumolylation of C/EBPbeta1 in breast cancer cells may be a mechanism to circumvent oncogene-induced senescence

The impact of regulating board gender diversity on the trickle-down effect: an attention-based view

This is the author accepted manuscript. The final version is available from the International Corporate Governance Society via the link in this record Research question/issue: Using an attention-based perspective of the firm, this study explores whether regulatory targets mandating women’s representation on corporate boards change the coordination of board and senior management appointment outcomes. Research findings/insights: Using a natural experiment design, in which British publicly traded firms encountered an exogenous regulatory shock on board gender composition, we uncover that regulation caused a disconnect of outcomes between the corporate board and senior management team, and, as a consequence, the trickle-down effect from appointing women at board level was removed after regulatory targets were implemented. Theoretical/academic implications: The study adds to literature on attention, providing empirical evidence that lower levels of attentional coherence are observed between the corporate board and senior management team after a major exogenous shock in the firm’s external environment. Departing form neo-institutional research investigating women in leadership and corporate governance, this study puts forward the attentional approach to explore the wider impact of legislating women’s representation on corporate boards. Practitioner/policy implications: Shifting board level attention towards the target of external regulatory requirements, and away from the internal environment, has an adverse impact on positive trickle-down effects once observed from appointing women to board level positions

Glocal integrity in 420 stainless steel by asynchronous laser processing

Cold working individual layers during additive manufacturing (AM) by mechanical surface treatments, such as peening, effectively “prints” an aggregate surface integrity that is referred to as a glocal (i.e., local with global implications) integrity. Printing a complex, pre-designed glocal integrity throughout the build volume is a feasible approach to improve functional performance while mitigating distortion. However, coupling peening with AM introduces new manufacturing challenges, namely thermal cancellation, whereby heat relaxes favorable residual stresses and work hardening when printing on a peened layer. Thus, this work investigates glocal integrity formation from cyclically coupling LENS® with laser peening on 420 stainless steel

Transcriptional profiling of zebrafish identifies host factors controlling susceptibility to Shigella flexneri

Shigella flexneri is a human-adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri has not been fully described. Zebrafish larvae represent a valuable model to study human infections in vivo. Here we use a Shigella-zebrafish infection model to generate mRNA expression profiles of host response to Shigella infection at the whole animal level. Immune response-related processes dominate the signature of early Shigella infection (6 hours post-infection). Consistent with its clearance from the host, the signature of late Shigella infection (24 hours post-infection) is significantly changed, and only a small set of immune-related genes remain differentially expressed, including acod1 and gpr84. Using mutant lines generated by ENU, CRISPR mutagenesis and F0 Crispants, we show that acod1- and gpr84-deficient larvae are more susceptible to Shigella infection. Together, these results highlight the power of zebrafish to model infection by bacterial pathogens and reveal the mRNA expression of the early (acutely infected) and late (clearing) host response to Shigella infection

Use of Energy Consumption during Milling to Fill a Measurement Gap in Hybrid Additive Manufacturing

Coupling additive manufacturing (AM) with interlayer peening introduces bulk anisotropic properties within a build across several centimeters. Current methods to map high resolution anisotropy and heterogeneity are either destructive or have a limited penetration depth using a nondestructive method. An alternative pseudo-nondestructive method to map high-resolution anisotropy and heterogeneity is through energy consumption during milling. Previous research has shown energy consumption during milling correlates with surface integrity. Since surface milling of additively manufactured parts is often required for post-processing to improve dimensional accuracy, an opportunity is available to use surface milling as an alternative method to measure mechanical properties and build quality. The variation of energy consumption during the machining of additive parts, as well as hybrid AM parts, is poorly understood. In this study, the use of net cutting specific energy was proposed as a suitable metric for measuring mechanical properties after interlayer ultrasonic peening of 316 stainless steel. Energy consumption was mapped throughout half of a cuboidal build volume. Results indicated the variation of net cutting specific energy increased farther away from the surface and was higher for hybrid AM compared to as-printed and wrought. The average lateral and layer variation of the net cutting specific energy for printed samples was 81% higher than the control, which indicated a significantly higher degree of heterogeneity. Further, it was found that energy consumption was an effective process signature exhibiting strong correlations with microhardness. Anisotropy based on residual strains were measured using net cutting specific energy and validated by hole drilling. The proposed technique contributes to filling part of the measure gap in hybrid additive manufacturing and capitalizes on the preexisting need for machining of AM parts to achieve both goals of surface finish and quality assessment in one milling operation

Rural Parent\u27s Experiences of Stress and Resilience During the COVID-19 Pandemic and School Closure

The COVID-19 pandemic has generated social and economic disruptions, resulting in cascading effects on the health and well-being of global citizens. However, little research has focused on how COVID-19 has affected rural regions, despite rurality being a critical factor for understanding community impact and response to the pandemic. The purpose of this phenomenological study was to explore the experiences of rural Nebraskan parents with young children during the COVID-19 pandemic and school shutdown, and the strategies they used to support their families during that time. We conducted individual and group interviews with 22 white, non-Hispanic mothers living in rural towns, villages, and farms in the Great Plains region of the United States. Thematic analysis was used to generate the following themes related to pandemic challenges: Impacts on Children’s Education and Development, Impact on Parent’s Work, and Social-emotional Impacts. Additionally, we generated themes related to the ways that rural parents responded to those challenges: Successful Parenting Strategies, Children’s Strategies, Using Community Provided Resources, Finding Unexpected Benefits, and Hope. This study is meaningful because it documented the impact of the COVID-19 pandemic and school shutdown on rural families with young children, and their responses to pandemic-related stressors. Our findings provide further insights into families’ experiences of how COVID-19 affected their lives. Limitations and future directions are also discussed