Activation of Natural Zeolite as Water Adsorbent for Mixed-Adsorption Drying

Mixed-adsorption drying with material using zeolite is an option to improve product quality and energy efficiency of drying seeds. In this case, zeolite and seeds are mixed and fluidized by warm air as drying medium. The air will desorb water from seed, and at the same time, zeolite will adsorb vapor from air. Thus, the driving force of drying can be kept high. However, in Indonesia, the zeolite with high adsorption capacity is hardly found in market. This research studied the activation of natural zeolite using two different methods: by heating at 200-400oC, and adding NaOH 0.5-2.0 N. Results showed that the adsorbing capacity of zeolite activated by 1.0 N NaOH is 0.170 gr water/gr dry zeolite. While, by heating at 300oC for 3 hours, is 0.140 gr water loaded/gr dry zeolite. With the performance, zeolite can be used for drying application. Keywords: zeolite, fluidized, adsorption, drying, activatio

Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Developing effective therapeutics for complex diseases such as late-onset, sporadic Alzheimer's disease (SAD) is difficult due to genetic and environmental heterogeneity in the human population and the limitations of existing animal models. Here, we used hiPSC-derived neurons to test a compound that stabilizes the retromer, a highly conserved multiprotein assembly that plays a pivotal role in trafficking molecules through the endosomal network. Using this human-specific system, we have confirmed previous data generated in murine models and show that retromer stabilization has a potentially beneficial effect on amyloid beta generation from human stem cell-derived neurons. We further demonstrate that manipulation of retromer complex levels within neurons affects pathogenic TAU phosphorylation in an amyloid-independent manner. Taken together, our work demonstrates that retromer stabilization is a promising candidate for therapeutic development in AD and highlights the advantages of testing novel compounds in a human-specific, neuronal system

UV-Completion by Classicalization

We suggest a novel approach to UV-completion of a class of non-renormalizable theories, according to which the high-energy scattering amplitudes get unitarized by production of extended classical objects (classicalons), playing a role analogous to black holes, in the case of non-gravitational theories. The key property of classicalization is the existence of a classicalizer field that couples to energy-momentum sources. Such localized sources are excited in high-energy scattering processes and lead to the formation of classicalons. Two kinds of natural classicalizers are Nambu-Goldstone bosons (or, equivalently, longitudinal polarizations of massive gauge fields) and scalars coupled to energy-momentum type sources. Classicalization has interesting phenomenological applications for the UV-completion of the Standard Model both with or without the Higgs. In the Higgless Standard Model the high-energy scattering amplitudes of longitudinal $W$-bosons self-unitarize via classicalization, without the help of any new weakly-coupled physics. Alternatively, in the presence of a Higgs boson, classicalization could explain the stabilization of the hierarchy. In both scenarios the high-energy scatterings are dominated by the formation of classicalons, which subsequently decay into many particle states. The experimental signatures at the LHC are quite distinctive, with sharp differences in the two cases.Comment: 37 page

The changing relationship between surface temperatures and Indian monsoon rainfall with the phase of ESI tendency

ffective Strength Index (ESI) is the relative strength of NAO and SO. ESI tendency is the algebraic difference between April-ESI and January-ESI and it represents the simultaneous evolution of NAO and SO from winter to spring. During positive (negative) phase of ESI tendency, NAO restores positive (negative) phase and SO restores negative (positive) phase before the beginning of summer season. Thus during contrasting phases (positive and negative) of ESI tendency, the evolution of NAO and SO is out of phase. In this paper we have studied the spatial and temporal variability of winter-time temperature field over Europe, Arabian Sea and Bay of Bengal during contrasting phases of ESI tendency. The study reveals that during positive (negative) ESI tendency, smaller (larger) region of Europe is showing significant winter-time cooling (warming) at surface. The relationship between winter-time surface temperature over above regions and Indian summer monsoon rainfall (ISMR) also shows spatial and temporal variability. The probable explanation for this change in the relationship is discussed in the paper. Two sets of temperature parameters for two different phases of ESI tendency are found out. Multiple regression equations are developed for the prediction of ISMR in each phase of ESI tendency. The performance of these equations is also discussed in this paper

Prediction of Indian summer monsoon rainfall using surface temperature and sea-level pressure cluster parameters

The scientific community has been putting in continuous efforts to improve long-range forecast of Indian summer monsoon rainfall (ISMR). In this study we try to search for new predictors which may improve the prediction of ISMR. The shared nearest neighbour technique has been applied to surface temperature (ST) and sea-level pressure (SLP) to obtain the clusters in pre-monsoon months (January through May) and seasons (winter, spring). The powers of time series averaged over the clusters are used as parameters for predicting ISMR. Instead of a single prediction equation, two separate equations are developed based on the positive and negative phase of effective strength index (ESI) tendency. Simple multiple regression equations are developed using these cluster parameters for predicting ISMR during the contrasting phases of ESI tendency. During positive (negative) phase of ESI tendency, the SLP (ST) cluster parameters can predict ISMR. The prediction of ISMR is improved if we use the prediction equation depending upon the phase of ESI tendency

Estimating the wind energy potential over the coastal stations of Nigeria using power law and diabatic methods

The suitability of two coastal stations in Nigeria for wind energy generation is presented in this study. To estimate the wind speeds at the desired height 70 m for standard wind turbine, two methods; namely power law relationship and diabatic evaluation have been considered. It was found that the diabatic evaluation method performed better because certain physical conditions of farm site are included in the method. Thus when potential site data are not available diabatic method can provide a good approximation of wind speeds. Comparing the energy potential of the two coastal stations, Lagos and Calabar in this study, it was found that Lagos has stronger wind speeds than Calabar especially during peak periods. The atmospheric condition most suitable to obtain maximum wind speeds was also found to be during stable condition. Stable condition occurs mostly in the night time.Keywords: Wind potential energy, wind turbine, power law, diabatic evaluation

Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells.

β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic function of β-catenin. However, the effect of Siah1 on the cell membrane bound β-catenin has not been studied. In this study, we identified that the carcinogenic bacterium H. pylori increased ETS2 transcription factor-mediated Siah1 protein expression in gastric cancer cells (GCCs) MKN45, AGS and Kato III. Siah1 protein level was also noticeably higher in gastric adenocarcinoma biopsy samples as compared to non-cancerous gastric epithelia. Siah1 knockdown significantly decreased invasiveness and migration of H. pylori-infected GCCs. Although, Siah1 could not increase degradation of the cytosolic β-catenin and its nuclear translocation, it enhanced degradation of the membrane-bound β-catenin in the infected GCCs. This loss of membrane-bound pool of β-catenin was not associated with the proteasomal degradation of E-cadherin. Thus, this work delineated the role of Siah1 in increasing invasiveness of H. pylori-infected GCCs

The Multi-center Evaluation of the Accuracy of the Contrast MEdium INduced Pd/Pa RaTiO in Predicting FFR (MEMENTO-FFR) Study.

AIMS: Adenosine administration is needed for the achievement of maximal hyperaemia fractional flow reserve (FFR) assessment. The objective was to test the accuracy of Pd/Pa ratio registered during submaximal hyperaemia induced by non-ionic contrast medium (contrast FFR [cFFR]) in predicting FFR and comparing it to the performance of resting Pd/Pa in a collaborative registry of 926 patients enrolled in 10 hospitals from four European countries (Italy, Spain, France and Portugal). METHODS AND RESULTS: Resting Pd/Pa, cFFR and FFR were measured in 1,026 coronary stenoses functionally evaluated using commercially available pressure wires. cFFR was obtained after intracoronary injection of contrast medium, while FFR was measured after administration of adenosine. Resting Pd/Pa and cFFR were significantly higher than FFR (0.93±0.05 vs. 0.87±0.08 vs. 0.84±0.08, p<0.001). A strong correlation and a close agreement at Bland-Altman analysis between cFFR and FFR were observed (r=0.90, p<0.001 and 95% CI of disagreement: from -0.042 to 0.11). ROC curve analysis showed an excellent accuracy (89%) of the cFFR cut-off of ≤0.85 in predicting an FFR value ≤0.80 (AUC 0.95 [95% CI: 0.94-0.96]), significantly better than that observed using resting Pd/Pa (AUC: 0.90, 95% CI: 0.88-0.91; p<0.001). A cFFR/FFR hybrid approach showed a significantly lower number of lesions requiring adenosine than a resting Pd/Pa/FFR hybrid approach (22% vs. 44%, p<0.0001). CONCLUSIONS: cFFR is accurate in predicting the functional significance of coronary stenosis. This could allow limiting the use of adenosine to obtain FFR to a minority of stenoses with considerable savings of time and costs.info:eu-repo/semantics/publishedVersio