Common visual problems in children with disability

Children with disability are at a substantially higher risk of visual impairment (VI) (10.5% compared with 0.16%) but also of ocular disorders of all types, including refractive errors and strabismus. The aetiology of VI in children with disability reflects that of the general population and includes cerebral VI, optic atrophy, as well as primary visual disorders such as retinal dystrophies and structural eye anomalies. VI and other potentially correctable ocular disorders may not be recognised without careful assessment and are frequently unidentified in children with complex needs. Although assessment may be more challenging than in other children, identifying these potential additional barriers to learning and development may be critical. There is a need to develop clearer guidelines, referral pathways and closer working between all professionals involved in the care of children with disability and visual disorders to improve our focus on the assessment of vision and outcomes for children with disability

Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase

<b>Objective</b>— Proatherosclerotic adhesion of leukocytes to the endothelium is attenuated by NO. As AMP-activated protein kinase (AMPK) regulates endothelial NO synthesis, we investigated the modulation of adhesion to cultured human aortic endothelial cells (HAECs) by AMPK. <b>Methods and Results</b>— HAECs incubated with the AMPK activator, AICAR, or expressing constitutively active AMPK demonstrated reduced TNF α-stimulated adhesion of promonocytic U-937 cells. Rapid inhibition of TNF α-stimulated U-937 cell adhesion by AICAR was NO-dependent, associated with unaltered cell surface adhesion molecule expression, and reduced MCP-1 secretion by HAECs. In contrast, inhibition of TNF α-stimulated U-937 cell adhesion by prolonged AMPK activation was NO-independent and associated with reduced cell surface adhesion molecule expression. <b>Conclusions</b>— AMPK activation in HAECs inhibits TNF α-stimulated leukocyte adhesion by a rapid NO-dependent mechanism associated with reduced MCP-1 secretion and a late NO-independent mechanism whereby adhesion molecule expression, in particular E-selectin, is suppressed. We investigated the functional effects of AMPK activation in cultured human endothelial cells. Stimulation of AMPK inhibited TNF α-stimulated monocyte adhesion by two distinct mechanisms: a rapid NO-dependent mechanism associated with a reduction in chemokine release and a late NO-independent mechanism whereby adhesion molecule expression is suppressed

The Icelandic Langspil

Some of the elements of Icelandic traditional music and its uniqueness are explained, and information about the traditional Icelandic instrument called the langspil is provided

Information Literacy Initiatives at the Otterbein University Library

This presentation explores the important focus that has been placed on information literacy instruction at Otterbein University in Westerville, Ohio, and examines strategies being developed to promote information literacy competency among Otterbein University students

Pleasant Ohio: Songs of Ohio\u27s History Accompanied by Mountain Dulcimer

Pleasant Ohio is a collection of fifteen songs covering both daily life and historical events related to the state of Ohio. Songs are in chronological order and span the time period from the historic Native Americans in Ohio through the end of the nineteenth century. Includes solo vocals with drum or mountain dulcimer accompaniment.https://digitalcommons.otterbein.edu/fac_bk/1001/thumbnail.jp

Direct administration of 2-hydroxypropyl-beta-cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements

<p>Cochlear response measurements from two different animals made before (red) and after (blue) treatment with HPβCD (Panel A) and TTX (Panel B) to 80 dB SPL 4 kHz tone bursts. Cochlear response waveform maintained CAP-like morphology after HPβCD treatment, consistent with reduced mechanical drive to neural excitation (Panel B, blue). In contrast, response waveform is EPSP-like following TTX treatment. Unlike TTX, results from HPβCD do not support the hypothesis that the auditory nerve is a site of action for 13 mM HPβCD.</p

Far Across the Ocean: An Otterbein Librarian at Shanghai Jiao Tong University

This presentation, done for the OPAL (Ohio Private Academic Libraries) Consortium Annual Conference, describes what Elizabeth (Betsy) Salt, Cataloger/Metadata Librarian at Otterbein University in Westerville, Ohio, learned about Chinese academic libraries and library practices while serving as an exchange librarian at the libraries of Shanghai Jiao Tong University in Shanghai, China during a portion of the months of June and July in 2011. Photos from travel in China which immediately followed the librarian exchange are also included

Cooperative Cataloging in Academic Libraries: From Mesopotamia to Metadata

This presentation provides a short historical survey of the development of library cataloging in the Western world and includes information on the gradual growth of cooperation among libraries in terms of using shared standardized cataloging rules and classification systems. Contemporary cooperation in cataloging is also covered focusing on cataloging facilitated by OCLC (Online Computer Library Center), OhioLINK, and the OPAL (Ohio Private Academic Libraries) Consortium. Cooperative cataloging and metadata initiatives are becoming increasingly important in the United States and internationally

Buckeye Heritage: Ohio\u27s History in Song

Buckeye Heritage: Ohio\u27s History in Song provides a unique look at the history of the state of Ohio from the time of the Native American inhabitants through the end of the nineteenth century. Representative traditional songs about various events and aspects of Ohio history are presented along with text that places each song in its historical context. Appalachian dulcimer tablature and dulcimer and guitar chords for each song are included in an appendix.https://digitalcommons.otterbein.edu/fac_bk/1000/thumbnail.jp

Heavy Quark Parameters and Vcb from Spectral Moments in Semileptonic B Decays

We extract the heavy quark masses and non-perturbative parameters from the Delphi preliminary measurements of the first three moments of the charged lepton energy and hadronic mass distributions in semileptonic B decays, using a multi-parameter fit. We adopt two formalisms, one of which does not rely on a 1/mc expansion and makes use of running quark masses. The data are consistent and the level of accuracy of the experimental inputs largely determines the present sensitivity. The results allow to improve on the uncertainty in the extraction of Vcb.Comment: 13 pages, 2 figure