Inhibition of tumor necrosis factor α–stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase

<b>Objective</b>— Proatherosclerotic adhesion of leukocytes to the endothelium is attenuated by NO. As AMP-activated protein kinase (AMPK) regulates endothelial NO synthesis, we investigated the modulation of adhesion to cultured human aortic endothelial cells (HAECs) by AMPK. <b>Methods and Results</b>— HAECs incubated with the AMPK activator, AICAR, or expressing constitutively active AMPK demonstrated reduced TNF α-stimulated adhesion of promonocytic U-937 cells. Rapid inhibition of TNF α-stimulated U-937 cell adhesion by AICAR was NO-dependent, associated with unaltered cell surface adhesion molecule expression, and reduced MCP-1 secretion by HAECs. In contrast, inhibition of TNF α-stimulated U-937 cell adhesion by prolonged AMPK activation was NO-independent and associated with reduced cell surface adhesion molecule expression. <b>Conclusions</b>— AMPK activation in HAECs inhibits TNF α-stimulated leukocyte adhesion by a rapid NO-dependent mechanism associated with reduced MCP-1 secretion and a late NO-independent mechanism whereby adhesion molecule expression, in particular E-selectin, is suppressed. We investigated the functional effects of AMPK activation in cultured human endothelial cells. Stimulation of AMPK inhibited TNF α-stimulated monocyte adhesion by two distinct mechanisms: a rapid NO-dependent mechanism associated with a reduction in chemokine release and a late NO-independent mechanism whereby adhesion molecule expression is suppressed

Pleasant Ohio: Songs of Ohio\u27s History Accompanied by Mountain Dulcimer

Pleasant Ohio is a collection of fifteen songs covering both daily life and historical events related to the state of Ohio. Songs are in chronological order and span the time period from the historic Native Americans in Ohio through the end of the nineteenth century. Includes solo vocals with drum or mountain dulcimer accompaniment.https://digitalcommons.otterbein.edu/fac_bk/1001/thumbnail.jp

Direct administration of 2-hydroxypropyl-beta-cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements

<p>Cochlear response measurements from two different animals made before (red) and after (blue) treatment with HPβCD (Panel A) and TTX (Panel B) to 80 dB SPL 4 kHz tone bursts. Cochlear response waveform maintained CAP-like morphology after HPβCD treatment, consistent with reduced mechanical drive to neural excitation (Panel B, blue). In contrast, response waveform is EPSP-like following TTX treatment. Unlike TTX, results from HPβCD do not support the hypothesis that the auditory nerve is a site of action for 13 mM HPβCD.</p

Far Across the Ocean: An Otterbein Librarian at Shanghai Jiao Tong University

This presentation, done for the OPAL (Ohio Private Academic Libraries) Consortium Annual Conference, describes what Elizabeth (Betsy) Salt, Cataloger/Metadata Librarian at Otterbein University in Westerville, Ohio, learned about Chinese academic libraries and library practices while serving as an exchange librarian at the libraries of Shanghai Jiao Tong University in Shanghai, China during a portion of the months of June and July in 2011. Photos from travel in China which immediately followed the librarian exchange are also included

Heavy Quark Parameters and Vcb from Spectral Moments in Semileptonic B Decays

We extract the heavy quark masses and non-perturbative parameters from the Delphi preliminary measurements of the first three moments of the charged lepton energy and hadronic mass distributions in semileptonic B decays, using a multi-parameter fit. We adopt two formalisms, one of which does not rely on a 1/mc expansion and makes use of running quark masses. The data are consistent and the level of accuracy of the experimental inputs largely determines the present sensitivity. The results allow to improve on the uncertainty in the extraction of Vcb.Comment: 13 pages, 2 figure

Implementation of RDA in the OPAL Consortium

The RDA Working Group, an informal subcommittee of the OPAL (Ohio Private Academic Libraries) Cataloging Committee was formed in 2011 to research the then under development RDA (Resource Description and Access) cataloging code and make recommendations to the entire membership of the OPAL Cataloging Committee on how to proceed with implementing RDA cataloging in the 24 small academic libraries which make up the OPAL Consortium. All of the OPAL libraries share one Innovative Interfaces, Inc. library system and share a public catalog, so it was important to develop some guidelines for RDA cataloging that all of the OPAL catalogers could follow. The OPAL Cataloging Committee recommended that the OPAL catalogers begin to use the RDA cataloging code on the date when the Library of Congress officially adopted RDA for all of its cataloging on March 31, 2013. At that time it became acceptable to add copy cataloged or original cataloged RDA records to the OPAL catalog. The OPAL Consortium purchased individual library subscriptions to the RDA Toolkit for each of the OPAL libraries, thereby providing all of the OPAL libraries with access to the premier tool for searching for RDA cataloging rules. In addition the RDA Working Group has also created some RDA training materials which include a MARC format field-by-field guide and examples of specific catalog records to show the differences in cataloging practice between AACR2 and RDA. These are accessible on the OPAL Cataloging Committee website for the OPAL catalogers to refer to as needed. Since all of the OPAL catalogers are contributing to a shared catalog, it is important for everyone “to be on the same page” in terms of RDA cataloging in OPAL, and the training materials created for OPAL catalogers have helped to facilitate a smooth transition to RDA among the catalogers of the OPAL consortium. OPAL catalogers also can contact each other with RDA questions through a listserv or through e-mail. This presentation includes a little theoretical background on the RDA cataloging code but will be largely practical in nature showing examples from some of the training materials created for the OPAL catalogers that may be helpful to other catalogers who are beginning to encounter RDA records in OCLC more and more frequently in copy cataloging and who are beginning to perform original cataloging following the rules of the RDA cataloging code

Single-kernel ionomic profiles are highly heritable indicators of genetic and environmental influences on elemental accumulation in maize grain (Zea mays)

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