Reporting ethics committee approval and patient consent by study design in five general medical journals.

BACKGROUND: Authors are required to describe in their manuscripts ethical approval from an appropriate committee and how consent was obtained from participants when research involves human participants. OBJECTIVE: To assess the reporting of these protections for several study designs in general medical journals. DESIGN: A consecutive series of research papers published in the Annals of Internal Medicine, BMJ, JAMA, Lancet and The New England Journal of Medicine between February and May 2003 were reviewed for the reporting of ethical approval and patient consent. Ethical approval, name of approving committee, type of consent, data source and whether the study used data collected as part of a study reported elsewhere were recorded. Differences in failure to report approval and consent by study design, journal and vulnerable study population were evaluated using multivariable logistic regression. RESULTS: Ethical approval and consent were not mentioned in 31% and 47% of manuscripts, respectively. 88 (27%) papers failed to report both approval and consent. Failure to mention ethical approval or consent was significantly more likely in all study designs (except case-control and qualitative studies) than in randomised controlled trials (RCTs). Failure to mention approval was most common in the BMJ and was significantly more likely than in The New England Journal of Medicine. Failure to mention consent was most common in the BMJ and was significantly more likely than in all other journals. No significant differences in approval or consent were found when comparing studies of vulnerable and non-vulnerable participants. CONCLUSION: The reporting of ethical approval and consent in RCTs has improved, but journals are less good at reporting this information for other study designs. Journals should publish this information for all research on human participants

Magnetic Behavior in RRhX (R = rare earths; X=B, C) Compounds

We report on the magnetic behavior of RRhB (R = La, Ce, Pr, Nd, Gd, Tb and Tm) and RRhC (R = La, Ce, Pr and Gd) compounds crystallizing in the cubic perovskite type structure with space group Pm3m. The heat capacity data on Pauli-paramagnetic LaRhB and LaRhC indicate a high frequency vibrating motion of boron and carbon atoms in the unit cell. Ce is in -like nonmagnetic state in both the compounds. Pr compounds show a dominant crystal field effect with a nonmagnetic singlet ground state in PrRhB and a nonmagnetic quadrupolar doublet in PrRhC. Compounds with other rare earths order ferromagnetically at low temperatures except TmRhB in which the zero field evolution of magnetic interactions is relatively more complicated. The electrical resistivity of GdRhB decreases with increasing temperature in the paramagnetic state in the vicinity of T, which is rarely seen in ferromagnets. The behavior is discussed to be arising due to the short range spin fluctuation and a possible contribution from Fermi surface geometry.Comment: 14 Figs and a text fil

Harvest-induced evolution and effective population size

Much has been written about fishery-induced evolution (FIE) in exploited species, but relatively little attention has been paid to the consequences for one of the most important parameters in evolutionary biology-effective population size (N-e). We use a combination of simulations of Atlantic cod populations experiencing harvest, artificial manipulation of cod life tables, and analytical methods to explore how adding harvest to natural mortality affects N-e, census size (N), and the ratio N-e/N. We show that harvest-mediated reductions in N-e are due entirely to reductions in recruitment, because increasing adult mortality actually increases the N-e/N ratio. This means that proportional reductions in abundance caused by harvest represent an upper limit to the proportional reductions in N-e, and that in some cases N-e can even increase with increased harvest. This result is a quite general consequence of increased adult mortality and does not depend on harvest selectivity or FIE, although both of these influence the results in a quantitative way. In scenarios that allowed evolution, N-e recovered quickly after harvest ended and remained higher than in the preharvest population for well over a century, which indicates that evolution can help provide a long-term buffer against loss of genetic variability.Peer reviewe

PMS62 A Multi-Country Physician Survey On Patient Eligibility And Use Of Biologics In Rheumatoid Arthritis (Ra), Ankylosing Spondylitis (As) And Psoriatic Arthritis (Psa) In European Union (Eu)

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CrimeBB: Enabling cybercrime research on underground forums at scale

Underground forums allow criminals to interact, exchange knowledge, and trade in products and services. They also provide a pathway into cybercrime, tempting the curious to join those already motivated to obtain easy money. Analysing these forums enables us to better understand the behaviours of offenders and pathways into crime. Prior research has been valuable, but limited by a reliance on datasets that are incomplete or outdated. More complete data, going back many years, allows for comprehensive research into the evolution of forums and their users. We describe CrimeBot, a crawler designed around the particular challenges of capturing data from underground forums. CrimeBot is used to update and maintain CrimeBB, a dataset of more than 48m posts made from 1m accounts in 4 different operational forums over a decade. This dataset presents a new opportunity for large-scale and longitudinal analysis using up-to-date information. We illustrate the potential by presenting a case study using CrimeBB, which analyses which activities lead new actors into engagement with cybercrime. CrimeBB is available to other academic researchers under a legal agreement, designed to prevent misuse and provide safeguards for ethical research

Magnetic Anisotropy in Single Crystalline CeAu2_{2}In4_{4}

We have grown the single crystals of LaAu$_{2}$In$_{4}$ and CeAu$_{2}$In$_{4}$ by high temperature solution method and report on the anisotropic magnetic behavior of CeAu$_{2}$In$_{4}$ . The compounds crystallize in an orthorhombic structure with space group \textit {Pnma}. LaAu$_{2}$In$_{4}$ shows a Pauli-paramagnetic behavior. CeAu$_{2}$In$_{4}$ do not order down to 1.8 K. The easy axis of magnetization for CeAu$_{2}$In$_{4}$ is along [010] direction. The magnetization data is analyzed on the basis of crystalline electric field (CEF) model.Comment: 7 figures 4 page

Evaluating the complexity of service-learning practices: lessons from and for complex systems theory

This article examines the intersection of service-learning with complex systems theory. It is based on a research project we undertook to explore whether complex systems theory might be useful for better understanding the dynamics of service-learning practice and thus for assisting in the design, running, and evaluation of service-learning projects. Additionally, we were interested to find out whether the specifics of our service-learning experience and knowledge, what we refer to as "critical service-learning," might have something of value to contribute to the interdisciplinary and ever-broadening paradigm of complexity studies. Our findings respond to these two tasks in the affirmative: We conclude complex systems theory can be of benefit to service-learning practice in a conceptual, operational, and strategic capacity. In instances where critical service-learning practice initially appears to be incongruent with complex systems theory, conversely these instances instead highlight precisely how service-learning could advance the analysis of systems in complexity studies