3,606 research outputs found
Magnetically controlled torque wrench prevents overtorquing
Magnetically controlled torque wrench produces the required torque values accurately, and prevents overtorquing. The force between a magnet and a soft iron bar on the arms of the wrench constitutes a predetermined maximum torque that cannot be exceeded. So long as the magnetic flux remain constant, the torque remains the same
Increasing Awareness of Type 3 Diabetes: Present and Future Implications
Background: In the United States alone, Type 2 Diabetes is the 7th leading cause of death, with Alzheimer’s Disease ahead as the 6th leading cause of mortality. While specific mechanisms have yet to be recognized by mainstream medicine, the term Type 3 Diabetes has been adopted to describe diabetes of the brain. Overarching commonalities amongst each disease include (a) oxidative stress, (b) inflammation, (c) mitochondrial dysfunction, and (d) neuroendocrine abnormalities. Collectively, these factors have been found to directly contribute to pro-death genes, impaired energy metabolism, and cerebral hypoperfusion. Yet, Type 2 Diabetes remains one of the most adjustable risk factors for the development of Alzheimer’s Disease. This dissertation explores the available literature on increasing the awareness of Type 3 Diabetes in terms of present and future implications. Methods: The review highlighted the following topics: (a) Alzheimer’s disease, (b) Types 1 and 2 diabetes, (c) insulin resistance and cognitive decline, (d) Type 3 diabetes (e) ApoE(4) genetic perturbations, (f) prevention and lifestyle support for Alzheimer’s disease, (g) prevention and lifestyle support for diabetes, (h) social and economic consequences of Alzheimer’s disease, (I) social and economic consequences of diabetes. Results: While AD is a complex disorder, there is a plethora of irrefutable research that supports viewing it as Type 3 Diabetes. Increasing patient education of Type 3 Diabetes and focusing on prevention strategies would decrease disease burden, increase quality of life and at the same time, save trillions of dollars in healthcare spending. Conclusions: Since there is no pharmaceutical cure for AD, increasing awareness of Type 3 Diabetes has the potential to provide patients with sustainable, integrative therapies, allowing them to become invested in their health choices. This will also promote individual accountability and a sense of conscientiousness in taking back one’s own health through lifestyle choices while reducing unnecessary suffering for patients, family members and society
Compressible sleeve provides automatic centering for grinding or turning of cylinders
Elastomeric sleeve supported on a threaded mandrel automatically centers cylindrical castings for grinding or turning. By expanding the diameter of the sleeve with pressure against the ends, the casting becomes rigidly supported and the surfacing operation can be completed
How specific is synchronous neuronal firing? : Poster presentation
Background Synchronous neuronal firing has been discussed as a potential neuronal code. For testing first, if synchronous firing exists, second if it is modulated by the behaviour, and third if it is not by chance, a large set of tools has been developed. However, to test whether synchronous neuronal firing is really involved in information processing one needs a direct comparison of the amount of synchronous firing for different factors like experimental or behavioural conditions. To this end we present an extended version of a previously published method NeuroXidence [1], which tests, based on a bi- and multivariate test design, whether the amount of synchronous firing above the chance level is different for different factors
GRTS operations monitor/control system
An Operations Monitor/Control System (OMCS) was developed to support remote ground station equipment. The ground station controls a Tracking Data Relay Satellite (TDRS) relocated to provide coverage in the tracking system's zone of exclusion. The relocated satellite significantly improved data recovery for the Gamma Ray Observatory mission. The OMCS implementation, performed in less than 11 months, was mission critical to TDRS drift operations. Extensive use of Commercial Off The Shelf (COTS) hardware and software products contributed to implementation success. The OMCS has been operational for over 9 months with no significant problems. This paper will share our experiences in OMCS development and integration
Evidence for Quantitative Trait Loci Affecting Ovulation Rate in Pigs
Fifty-five microsatellite markers were scored in an F2 population of pigs (n = 114 females) developed at the University of Nebraska. The population was produced by crossing a line previously selected for 10 generations using an index of ovulation rate and embryonal survival and a line selected at random. The lines were from a common base population and differed by 6.7 ovulations and 3.1 fetuses at 50 d of gestation. Ovulation rate and number of fully formed and mummified pigs were recorded for each female. Data were analyzed with regression models that included random animal effects. Likelihood-ratio tests were used to test for quantitative trait loci (QTL) effects by deviating the log-likelihood for the full model that included additive and dominance QTL effects from the log-likelihood for the reduced model that did not contain QTL effects. A QTL for ovulation rate was found on chromosome 8 (P \u3c .001) with an additive effect of 3.07 ovulations. Other evidence of potential QTL affecting ovulation rate was found on chromosomes 4 (P \u3c .10), 13, and 15 (P \u3c .05). Effects on chromosomes 4, 13, and 15 were not significant for an experiment-wise threshold value of P \u3c .001. No significant QTL for litter size or number of mummified pigs were found. Additional data are needed to confirm the location and the effect of QTL found for ovulation rate before markers associated with them can be used in marker-assisted selection
Evidence for Quantitative Trait Loci Affecting Ovulation Rate in Pigs
Fifty-five microsatellite markers were scored in an F2 population of pigs (n = 114 females) developed at the University of Nebraska. The population was produced by crossing a line previously selected for 10 generations using an index of ovulation rate and embryonal survival and a line selected at random. The lines were from a common base population and differed by 6.7 ovulations and 3.1 fetuses at 50 d of gestation. Ovulation rate and number of fully formed and mummified pigs were recorded for each female. Data were analyzed with regression models that included random animal effects. Likelihood-ratio tests were used to test for quantitative trait loci (QTL) effects by deviating the log-likelihood for the full model that included additive and dominance QTL effects from the log-likelihood for the reduced model that did not contain QTL effects. A QTL for ovulation rate was found on chromosome 8 (P \u3c .001) with an additive effect of 3.07 ovulations. Other evidence of potential QTL affecting ovulation rate was found on chromosomes 4 (P \u3c .10), 13, and 15 (P \u3c .05). Effects on chromosomes 4, 13, and 15 were not significant for an experiment-wise threshold value of P \u3c .001. No significant QTL for litter size or number of mummified pigs were found. Additional data are needed to confirm the location and the effect of QTL found for ovulation rate before markers associated with them can be used in marker-assisted selection
Stabilization of the γ-Sn phase in tin nanoparticles and nanowires
Structures of Sn nanoparticles and nanowires are studied using density
functional theory in conjunction with thermodynamic considerations. Besides
the low-temperature α and room-temperature β phases, the high-temperature γ
phase is considered. Results show that at ambient temperatures for sizes
smaller than 50 nm, metallic β- and γ-Sn nanoparticles are more stable than
semimetallic α-Sn ones because of their lower surface energies. Moreover, very
small Sn nanostructures, exemplified by nanowires, are expected to exhibit the
γ phase even at 0 K
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