Remagnetización alpina en la Serra del Cadí (Pirineo Oriental)

The eastern Pyrenees, particularly the Cadi Range, displays the less density and quality of paleomagnetic data of the chain. This paper revisited one of the central sections (Pobla de Lillet) where we have resampled Permian, Maastrichtian and Paleocene rocks. Best results were attained in the Permian red sandstones and in the Cretaceous limestones. In the Permian, two components with paleomagnetic meaning were identified. The high temperature component (up to 670 ° C) is similar to that defined in pioneering works, it appears to be primary and does not show significant rotations. The intermediate temperature component (up to 500 ° C), not identified in previous works, seems to be a syntectonic remagnetization with Alpine age. The characterization of rotations and the extension of this remagnetization (as an additional source of kinematics information) should be addressed in Permian rocks in future works since the paleomagnetic signal of Cenozoic rocks is of lower qualityTrabajo financiado con los Proyectos Pmag3Drest-CGL2009-14214 y DR3AM- CGL2014-55118 del MINECO y del 3DR3- PI165/09 del Gobierno de Aragón.Peer Reviewe

The early/middle Eocene transition at the Ésera valley (South-Central Pyrenees): Implications in Shallow Benthic Zones (SBZ)

An integrated study including magnetostratigraphy, larger benthic foraminifera and calcareous nannofossil biostratigraphy is presented herein. This work was performed in shallow marine siliciclastics rich in larger foraminifera, around the Ypresian/Lutetian boundary in the Ésera valley (South-Central Pyrenees). Although the calcareous nannofossil content in the studied interval is low, not allowing a precise Y/L boundary to be recognised, the taxa found are enough to support the chronostratigraphic attribution. Data obtained in the Ésera valley section has improved the knowledge of larger benthic foraminifera (Nummulites and Assilina) distribution through chron C21. SBZ 11 to SBZ 12 transition took place at the lowermost C21r, as shown in previous works. SBZ 12 assemblages extend into C21n, where the SBZ 12 to SBZ 13 boundary occurs. These data, obtained in shallow marine siliciclastic facies, with in situ fauna, results in a shift of the SBZ 12/SBZ 13 boundary to the Lower Lutetian, younger than previously believed. Accordingly, the Ypresian/Lutetian boundary occurs in SBZ 12. © A. Rodríguez-Pintó, J. Serra-Kiel, G. Bernaola, A. Barnolas, E.L. Pueyo, J. Tosquella, P. Arbués, R. Scholger, 2022 CC BY-SA

Basement-Cover Relationships and Their Along-Strike Changes in the Linking Zone (Iberian Range, Spain): A Combined Structural and Gravimetric Study

Contractional deformation in the transition between the Iberian and Catalan Coastal Ranges (Linking Zone) generated both thin-skinned structures detached in low-strength Triassic units and basement-involved structures. To evaluate their extent and relative contribution to the overall structure, we carried out a study combining structural geology and gravimetry. New gravity data (938 stations) and density determinations (827 samples) were acquired and combined with previous existing databases to obtain Bouguer anomaly and residual Bouguer anomaly maps of the study area. Seven serial and balanced cross sections were built, their depth geometries being constrained through the 2.5-D gravity modeling and the 3-D gravity inversion that we accomplished. The residual Bouguer anomaly map shows a good correlation between basement antiforms and gravity highs whereas negative anomalies mostly correspond to (i) Meso-Cenozoic synclines and (ii) Neogene-Quaternary basins. Cross sections depict a southern, thick-skinned domain where extensional, basement faults inherited from Late Jurassic-Early Cretaceous times were inverted during the Cenozoic. To the north, we interpret the existence of both Triassic-detached and basement-involved deformation domains. The two deformation styles are vertically overlapped in the southernmost part of the Catalan Coastal Ranges but relay both across and along strike in the Eastern Iberian Range. These basement and cover relationships and their along-strike variations are analyzed in terms of the interplay between structural inheritance, its obliquity to the shortening direction, and the continuity and effectiveness of Triassic décollements in the study area

Specific Plasma MicroRNA Signatures Underlying the Clinical Outcomes of Hepatitis E Virus Infection

The pathogenic mechanisms determining the diverse clinical outcomes of HEV infection (e.g., self-limiting vs chronic or symptomatic vs asymptomatic) are not yet understood. Because specific microRNA signatures during viral infection inform the cellular processes involved in virus replication and pathogenesis, we investigated plasma microRNA profiles in 44 subjects, including patients with symptomatic acute (AHE, n = 7) and chronic (CHE, n = 6) hepatitis E, blood donors with asymptomatic infection (HEV BDs, n = 9), and anti-HEV IgG+IgM- (exposed BDs, n = 10) and anti-HEV IgG-IgM- (naïve BDs, n = 12) healthy blood donors. By measuring the abundance of 179 microRNAs in AHE and naïve BDs by RT-qPCR, we identified 51 potencial HEV-regulated microRNAs (PBH < 0.05). Further analysis showed that HEV genotype 3 infection is associated with miR-122, miR-194, miR-885, and miR-30a upregulation and miR-221, miR-223, and miR-27a downregulation. AHE showed significantly higher levels of miR-122 and miR-194, and lower levels of miR-221, miR-27a, and miR-335 compared to HEV BDs. This specific microRNA signature in AHE could promote virus replication and reduce antiviral immune responses, contributing to the development of clinical symptoms. We found that mir-194, miR-335, and miR-221 can discriminate between asymptomatic HEV infections and those developing acute symptoms, whereas miR-335 correctly classify AHE and CHE. Conclusions: Our data suggest that diverse outcomes of HEV infection result from different HEV-induced microRNA dysregulations. The specific microRNA signatures described offer novel information that may serve to develop biomarkers of HEV infection outcomes and improve our understanding of HEV pathogenesis, which may facilitate the identification of antiviral targets

Petrophysical properties in the Iberian Range and surrounding areas (NE Spain): 1-density

We introduce the first map of density data in Northeastern Spain which can help in the interpretation of gravimetric surveying. The background map is a simplified version of the Geode continuous geological cartography (scale 1:200.000) of the Iberian Range and Ebro basin. These maps are synthetic and homogeneous maps based on previous 1:50, 000 scale geological maps (MAGNA). The map uses the ETRS89 datum and UTM coordinates (30T northern zone) and covers an area of 140, 000 sq km. The compiled data shown in the map come from previous papers of the region (˜ 700 points) as well as from more than 800 additional points developed in the course of an exploratory project focused on the underground characterization of a potential CO2 reservoir in the so-called ‘Linking Zone''. The new data accomplish some basic criteria; they are accurately georeferenced and lithology, stratigraphic age and other technical details about the measurements (e.g. means and error) and methods are fully displayed

10 Myr evolution of sedimentation rates in a deep marine to non-marine foreland basin system: Tectonic and sedimentary controls (Eocene, Tremp–Jaca Basin, Southern Pyrenees, NE Spain)

The propagation of the deformation front in foreland systems is typically accompanied by the incorporation of parts of the basin into wedge-top piggy-back basins, this process is likely producing considerable changes to sedimentation rates (SR). Here we investigate the spatial-temporal evolution of SR for the Tremp–Jaca Basin in the Southern Pyrenees during its evolution from a wedge-top, foreredeep, forebulge configuration to a wedge-top stage. SR were controlled by a series of tectonic structures that influenced subsidence distribution and modified the sediment dispersal patterns. We compare the decompacted SR calculated from 12 magnetostratigraphic sections located throughout the Tremp–Jaca Basin represent the full range of depositional environment and times. While the derived long-term SR range between 9.0 and 84.5 cm/kyr, compiled data at the scale of magnetozones (0.1–2.5 Myr) yield SR that range from 3.0 to 170 cm/kyr. From this analysis, three main types of depocenter are recognized: a regional depocenter in the foredeep depozone; depocenters related to both regional subsidence and salt tectonics in the wedge-top depozone; and a depocenter related to clastic shelf building showing transgressive and regressive trends with graded and non-graded episodes. From the evolution of SR we distinguish two stages. The Lutetian Stage (from 49.1–41.2 Ma) portrays a compartmentalized basin characterized by variable SR in dominantly underfilled accommodation areas. The markedly different advance of the deformation front between the Central and Western Pyrenees resulted in a complex distribution of the foreland depozones during this stage. The Bartonian–Priabonian Stage (41.2–36.9 Ma) represents the integration of the whole basin into the wedge-top, showing a generalized reduction of SR in a mostly overfilled relatively uniform basin. The stacking of basement units in the hinterland during the whole period produced unusually high SR in the wedge-top depozoneAgència de Gestió d'Ajuts Universitaris i de Recerca, Grant/Award Number: 2017SGR596; Secretaría de Estado de Investigación, Desarrollo e Innovación, Grant/Award Number: BES-2015-073302 and CGL2014-55900-P; Swiss National Science Foundation, Grant/Award Number: 200020_18201

Panorámicas para un corte de la vertiente surpirenaica en la zona de estructuras oblicuas de Aínsa – Valle del Cinca

En la vertiente meridional de los Pirineos, la franja comprendida entre las latitudes 0º9’30’’O y 0º26’30’’E, que tiene su eje en torno al valle del río Cinca, tiene caracteres peculiares en su estructura: la dirección de los pliegues y cabalgamientos se aparta de la dirección pirenaica dominante..

Glycemic index, glycemic load and invasive breast cancer incidence in postmenopausal women: The PREDIMED study

The objective of this study was to evaluate the prospective associations between dietary glycemic index (GI) and glycemic load (GL) and the risk for invasive breast cancer incidence in postmenopausal women at high cardiovascular disease (CVD) risk. This study was conducted within the framework of the PREvención con DIeta MEDiterránea (PREDIMED) study, a nutritional intervention trial for primary cardiovascular prevention. We included 4010 women aged between 60 and 80 years who were initially free from breast cancer but at high risk for CVD disease. Dietary information was collected using a validated 137-item food frequency questionnaire. We assigned GI values using the International Tables of GI and GL values. Cases were ascertained through yearly consultation of medical records and through consultation of the National Death Index. Only cases confirmed by results from cytology tests or histological evaluation were included. We estimated multivariable-adjusted hazard ratios for invasive breast cancer risk across tertiles of energy-adjusted dietary GI/GL using Cox regression models. We repeated our analyses using yearly repeated measures of GI/GL intakes. No associations were found between baseline dietary GI/GL and invasive breast cancer incidence. The multivariable hazard ratio and 95% confidence interval (CI) for the top tertile of dietary GI was 1.02 (95% CI: 0.42–2.46) and for dietary GL was 1.00 (95% CI: 0.44–2.30) when compared with the bottom tertile. Repeated-measures analyses yielded similar results. In sensitivity analyses, no significant associations were observed for women with obesity or diabetes. Dietary GI and GL did not appear to be associated with an increased risk for invasive breast cancer in postmenopausal women at high CVD risk

Analizando la cinética de las remagnetizaciones por enterramiento. El caso de la Cuenca turbidítica de Jaca (Pirineos occidentales).

X Congreso Geológico de España, 5-7 Julio 2021, Vitoria - GasteizLas remagnetizaciones químicas regionales relacionadas con procesos de enterramiento y diagénesis son un proceso ampliamente extendido en cuñas orogénicas y cuencas sedimentarias. Este proceso conlleva la neoformación autigénica de minerales ferromagnéticos s.l. en relación con el aumento de temperatura asociado al enterramiento. Sin embargo, todavía no se conoce bien la cinética de estos procesos, debido en parte a que la mayoría de las remagnetizaciones de este tipo descritas en la literatura científica se produjeron durante supercrones magnéticos. Los materiales turbidíticos eocenos de la Cuenca de Jaca (Pirineos Occidentales) muestran una remagnetización química de doble polaridad, registrando varios crones a lo largo de la secuencia sedimentaria remagnetizada. Dentro del proyecto UKRIA4D (PID2019-104693GB-I00/CTA), se va a realizar un estudio multidisciplinar para relacionar temperatura de enterramiento, mineralogía magnética y edad de la remagnetización con la que evaluar de manera empírica las relaciones cinéticas entre los distintos factores