3 research outputs found
Atomoxetine improves patient and family coping in attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in Swedish children and adolescents
This 10-week study assessed the efficacy of atomoxetine in combination with psychoeducation compared to placebo and psychoeducation in the improvement of Quality of Life in Swedish stimulant-naive children and adolescents with attention deficit/hyperactivity disorder. A total of 99 patients were treated with atomoxetine (49Ā patients) or placebo (50Ā patients) for 10Ā weeks and assessed regarding broader areas of functioning using the Quality of Life measures Child Health and Illness Profile-Child Edition (CHIP-CE), Family Strain Index [FSI; equivalent to the Family Burden of Illness Module used in the study], Appraisal of Stress in Child-Rearing (ASCR), Five to fifteen (FTF), āI think I amā (āJag tycker jag Ƥrā), and Childrenās Depression Rating Scale-Revised (CDRS-R) before and after the active treatment phase. Simultaneously, the patientsā parents participated in a 4-session psychoeducation program. A statistically significant difference in favor of atomoxetine was seen in the improvement from baseline to study endpoint for the CHIP-CE domains āAchievementā and āRisk avoidanceā, for the FSI total score, for the ASCR section (I) domain āChild as a burdenā, for all FTF domains except for āLanguage and Speechā, and for the CDRS-R total score. No difference between treatment groups was observed in the patient-assessed evaluation of self-esteem using the āI think I amā scale. Atomoxetine combined with psychoeducation had a positive effect on various everyday coping abilities of the patients as well as their families during 10Ā weeks of treatment, whereas the patientsā self-image and the parentsā image of the climate in the family were not significantly improved