The Role of CD40/CD40 Ligand Interactions in Bone Marrow Granulopoiesis

The CD40 ligand (CD40L) and CD40 are two molecules belonging to the TNF/TNF receptor superfamily, and their role in adaptive immune system has widely been explored. However, the wide range of expression of these molecules on hematopoietic as well as nonhematopoietic cells has revealed multiple functions of the CD40/CD40L interactions on different cell types and processes such as granulopoiesis. CD40 triggering on stromal cells has been documented to enhance the expression of granulopoiesis growth factors such as granulocyte-colony-stimulating factor (G-CSF) and granulocyte/monocyte-colony-stimulating factor (GM-CSF), and upon disruption of the CD40/CD40L-signaling pathway, as in the case of X-linked hyperimmunoglobulin M (IgM) syndrome (XHIGM), it can lead to neutropenia. In chronic idiopathic neutropenia (CIN) of adults, however, under the influence of an inflammatory microenvironment, CD40L plays a role in granulocytic progenitor cell depletion, providing thus a pathogenetic cause of CIN

Assessing end-user awareness of social engineering and phishing

Social engineering is a significant problem involving technical and nontechnical ploys in order to acquire information from unsuspecting users. This paper presents an assessment of user awareness of such methods in the form of email phishing attacks. Our experiment used a webbased survey, which presented a mix of 20 legitimate and illegitimate emails, and asked participants to classify them and explain the rationale for their decisions. This assessment shows that the 179 participants were 36% successful in identifying legitimate emails, versus 45% successful in spotting illegitimate ones. Additionally, in many cases, the participants who identified illegitimate emails correctly could not provide convincing reasons for their selections

Exploring the belief systems of domestic abuse victims using Smallest Space Analysis (SSA)

Research exploring domestic abuse victims has primarily focused on the shorter term avenues of support for victims and the risk factors which put women at risk of victimization. There is limited research exploring the belief systems of domestically abused women that need to be targeted to achieve longer term effects. The present study therefore explored the association between the beliefs of abused women and their experiences as victims. Twenty-one women with a history of domestic abuse were asked about their attitudes towards authority figures and perceived opportunities around the time of their abusive experience. Data were analyzed using Smallest Space Analysis (SSA). Four distinct belief themes (personal responsibility, antisocial attitudes, environmental factors, and negative police attitudes) were found in the analysis. The findings highlighted not only the importance of considering the long standing and personalized beliefs of abuse victims, but also demonstrates the need for support services to offer more personalized support to abuse victims to help change their belief systems. Although this research sets the groundwork in understanding the beliefs of domestic abuse victims, these results need to be built upon with future research examining the wider implications of targeting the belief systems of domestically abused women

Observing plasticity of the auditory system: Volumetric decreases along with increased functional connectivity in aspiring professional musicians

Playing music relies on several sensory systems and the motor system, and poses strong demands on control processes, hence, offering an excellent model to study how experience can mold brain structure and function. Although most studies on neural correlates of music expertise rely on cross-sectional comparisons, here we compared within-person changes over time in aspiring professionals intensely preparing for an entrance exam at a University of the Arts to skilled amateur musicians not preparing for a music exam. In the group of aspiring professionals, we observed gray-matter volume decrements in left planum polare, posterior insula, and left inferior frontal orbital gyrus over a period of about 6 months that were absent among the amateur musicians. At the same time, the left planum polare, the largest cluster of structural change, showed increasing functional connectivity with left and right auditory cortex, left precentral gyrus, left supplementary motor cortex, left and right postcentral gyrus, and left cingulate cortex, all regions previously identified to relate to music expertise. In line with the expansion–renormalization pattern of brain plasticity (Wenger et al., 2017a. Expansion and renormalization of human brain structure during skill acquisition. Trends Cogn Sci. 21:930–939.), the aspiring professionals might have been in the selection and refinement period of plastic change

The role of SH3BP2 in the pathophysiology of cherubism

Cherubism is a rare bone dysplasia that is characterized by symmetrical bone resorption limited to the jaws. Bone lesions are filled with soft fibrous giant cell-rich tissue that can expand and cause severe facial deformity. The disorder typically begins in children at ages of 2-5 years and the bone resorption and facial swelling continues until puberty; in most cases the lesions regress spontaneously thereafter. Most patients with cherubism have germline mutations in the gene encoding SH3BP2, an adapter protein involved in adaptive and innate immune response signaling. A mouse model carrying a Pro416Arg mutation in SH3BP2 develops osteopenia and expansile lytic lesions in bone and some soft tissue organs. In this review we discuss the genetics of cherubism, the biological functions of SH3BP2 and the analysis of the mouse model. The data suggest that the underlying cause for cherubism is a systemic autoinflammatory response to physiologic challenges despite the localized appearance of bone resorption and fibrous expansion to the jaws in humans

Energy, Environmental Impact and Indoor Environmental Quality of Add-Ons in Buildings

On a European scale, the existing building stock has poor energy performance and partic-ularly vulnerable structures. Indeed, most of the existing buildings were built before the introduction of energy standards and under structural safety criteria different from those currently required. It is therefore necessary the intervention in existing buildings according to an integrated approach that contemplates both the structural safety and the energy efficiency of buildings. This study, con-sistently with the objectives of the European research project “Proactive synergy of integrated Efficient Technologies on buildings’ Envelopes (Pro-GET-OnE)”, proposes a retrofit intervention for a student dormitory of the National and Kapodistrian University of Athens. The scope of the evaluation is to understand how an integrated intervention, that implies a structural and energy retrofit, as well as a spatial redistribution, leads to an improvement of the Indoor Environmental Quality (IEQ). In detail, the structural retrofit was performed through exoskeleton that leads to the addition of new living spaces and to a remodeling of the building facades. The energy retrofit regarded all three levers of energy efficiency, and thus the building envelope, the microclimatic control systems, and the systems from renewable sources. The integrated intervention, in addition to a reduction of energy demand, has led to advantages in terms of IEQ. Thermal comfort, both during summer and winter, is improved and the hours of suitable CO2 concentration pass from 34% in the pre-retrofit stage up to 100% in the post retrofit stage