Development of a scalable generic platform for adaptive optics real time control

The main objective of the present project is to explore the viability of an adaptive optics control system based exclusively on Field Programmable Gate Arrays (FPGAs), making strong use of their parallel processing capability. In an Adaptive Optics (AO) system, the generation of the Deformable Mirror (DM) control voltages from the Wavefront Sensor (WFS) measurements is usually through the multiplication of the wavefront slopes with a predetermined reconstructor matrix. The ability to access several hundred hard multipliers and memories concurrently in an FPGA allows performance far beyond that of a modern CPU or GPU for tasks with a well defined structure such as Adaptive Optics control. The target of the current project is to generate a signal for a real time wavefront correction, from the signals coming from a Wavefront Sensor, wherein the system would be flexible to accommodate all the current Wavefront Sensing techniques and also the different methods which are used for wavefront compensation. The system should also accommodate for different data transmission protocols (like Ethernet, USB, IEEE 1394 etc.) for transmitting data to and from the FPGA device, thus providing a more flexible platform for Adaptive Optics control. Preliminary simulation results for the formulation of the platform, and a design of a fully scalable slope computer is presented.Comment: Paper presented as part of SPIE ICOP 2015 Conference Proceeding

Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

Detecting aggregated amyloid peptides (Aβ plaques) presents targets for developing biomarkers of Alzheimer's disease (AD). Polymeric n-butyl-2-cyanoacrylate (PBCA) nanoparticles (NPs) were encapsulated with radiolabelled amyloid affinity 125I-clioquinol (CQ, 5-chloro-7-iodo-8-hydroxyquinoline) as in vivo probes. 125I-CQ-PBCA NPs crossed the BBB (2.3 ± 0.9 ID/g) (P < .05) in the WT mouse (N = 210), compared to 125I-CQ (1.0 ± 0.4 ID/g). 125I-CQ-PBCA NP brain uptake increased in AD transgenic mice (APP/PS1) versus WT (N = 38; 2.54 × 105 ± 5.31 × 104 DLU/mm2; versus 1.98 × 105 ± 2.22 × 104 DLU/mm2) and in APP/PS1/Tau. Brain increases were in mice intracranially injected with aggregated Aβ42 peptide (N = 17; 7.19 × 105 ± 1.25 × 105 DLU/mm2), versus WT (6.07 × 105 ± 7.47 × 104 DLU/mm2). Storage phosphor imaging and histopathological staining of the plaques, Fe2+ and Cu2+, validated results. 125I-CQ-PBCA NPs have specificity for Aβ in vitro and in vivo and are promising as in vivo SPECT (123I), or PET (124I) amyloid imaging agents

Unravelling the nature of HD 81032 - a new RS CVn Binary

BVR photometric and quasi-simultaneous optical spectroscopic observations of the star HD 81032 have been carried out during the years 2000 - 2004. A photometric period of $18.802 \pm 0.07$ d has been detected for this star. A large group of spots with a migration period of $7.43 \pm 0.07$ years is inferred from the first three years of the data. H$\alpha$ and Ca II H and K emissions from the star indicate high chromospheric activity. The available photometry in the BVRIJHK bands is consistent with spectral type of K0 IV previously found for this star. We have also examined the spectral energy distribution of HD 81032 for the presence of an infrared colour excess using the 2MASS JHK and IRAS photometry, but found no significant excess in any band abovethe normal values expected for a star with this spectral type. We have also analyzed the X-ray emission properties of this star using data obtained by the ROSAT X-ray observatory during its All-Sky Survey phase. An X-ray flare of about 12 hours duration was detected during the two days of X-ray coverage obtained for this star. Its X-ray spectrum, while only containing 345 counts, is inconsistent with a single-temperature component solar-abundance coronal plasma model, but implies either the presence of two or more plasma components, non-solar abundances, or a combination of both of these properties. All of the above properties of HD 81032 suggest that it is a newly identified, evolved RS CVn binary.Comment: 18 pages, 10 figures, 3 tables, Accepted for the publication in JAp

Templeting of Thin Films Induced by Dewetting on Patterned Surfaces

The instability, dynamics and morphological transitions of patterns in thin liquid films on periodic striped surfaces (consisting of alternating less and more wettable stripes) are investigated based on 3-D nonlinear simulations that account for the inter-site hydrodynamic and surface-energetic interactions. The film breakup is suppressed on some potentially destabilizing nonwettable sites when their spacing is below a characteristic lengthscale of the instability, the upper bound for which is close to the spinodal lengthscale. The thin film pattern replicates the substrate surface energy pattern closely only when, (a) the periodicity of substrate pattern matches closely with the characteristic lengthscale, and (b) the stripe-width is within a range bounded by a lower critical length, below which no heterogeneous rupture occurs, and an upper transition length above which complex morphological features bearing little resemblance to the substrate pattern are formed.Comment: 5 pages TeX (REVTeX 4), other comments: submitted to Phys. Rev.Let

Optical afterglow of the not so dark GRB 021211

We determine Johnson $B,V$ and Cousins $R,I$ photometric CCD magnitudes for the afterglow of GRB 021211 during the first night after the GRB trigger. The afterglow was very faint and would have been probably missed if no prompt observation had been conducted. A fraction of the so-called ``dark'' GRBs may thus be just ``optically dim'' and require very deep imaging to be detected. The early-time optical light curve reported by other observers shows prompt emission with properties similar to that of GRB 990123. Following this, the afterglow emission from $\sim 11$ min to $\sim 33$ days after the burst is characterized by an overall power-law decay with a slope $1.1\pm0.02$ in the $R$ passband. We derive the value of spectral index in the optical to near-IR region to be 0.6$\pm$0.2 during 0.13 to 0.8 day after the burst. The flux decay constant and the spectral slope indicate that optical observations within a day after the burst lies between cooling frequency and synchrotron maximum frequency.Comment: 4 pages, 2 figures, A&A Letters, 408, L2

The Density of Coronal Plasma in Active Stellar Coronae

We have analyzed high-resolution X-ray spectra of a sample of 22 active stars observed with the High Energy Transmission Grating Spectrometer on {\em Chandra} in order to investigate their coronal plasma density. Densities where investigated using the lines of the He-like ions O VII, Mg XI, and Si XIII. While Si XIII lines in all stars of the sample are compatible with the low-density limit, Mg XI lines betray the presence of high plasma densities ($> 10^{12}$ cm$^{-3}$) for most of the sources with higher X-ray luminosity ($> 10^{30}$ erg/s); stars with higher $L_X$ and $L_X/L_{bol}$ tend to have higher densities at high temperatures. Ratios of O VII lines yield much lower densities of a few $10^{10}$ cm$^{-3}$, indicating that the ``hot'' and ``cool'' plasma resides in physically different structures. Our findings imply remarkably compact coronal structures, especially for the hotter plasma emitting the Mg XI lines characterized by coronal surface filling factor, $f_{MgXI}$, ranging from $10^{-4}$ to $10^{-1}$, while we find $f_{OVII}$ values from a few $10^{-3}$ up to $\sim 1$ for the cooler plasma emitting the O VII lines. We find that $f_{OVII}$ approaches unity at the same stellar surface X-ray flux level as solar active regions, suggesting that these stars become completely covered by active regions. At the same surface flux level, $f_{MgXI}$ is seen to increase more sharply with increasing surface flux. These results appear to support earlier suggestions that hot $10^7$ K plasma in active coronae arises from flaring activity, and that this flaring activity increases markedly once the stellar surface becomes covered with active regions.Comment: 53 pages, 19 figures, accepted for publication in Astrophysical Journal. A version of the paper with higher quality figures is available from http://www.astropa.unipa.it/Library/preprint.htm

Long-Term V-Band Monitoring of the Bright Stars of M33 at the Wise Observatory

We have conducted a long-term V-band photometric monitoring of M33 on 95 nights during four observing seasons (2000 - 2003). A total number of 6418 lightcurves of bright objects in the range of 14 - 21 mag have been obtained. All measurements are publicly available. A total of 127 new variables were detected, of which 28 are periodic. Ten previously known non-periodic variables were identified as periodic, 3 of which are Cepheids, and another previously known periodic variable was identified as an eclipsing binary. Our derived periods range from 2.11 to almost 300 days. For 50 variables we have combined our observations with those of the DIRECT project, obtaining lightcurves of up to 500 measurements, with a time-span of ~7 years. We have detected a few interesting variables, including a 99.3 day periodic variable with a 0.04 mag amplitude, at the position of SNR 19.Comment: 29 pages, accepted for publication in MNRAS. Additional material is available at http://wise-obs.tau.ac.il/~shporer/m33

Chandipura virus: a major cause of acute encephalitis in children in North Telangana, Andhra Pradesh, India

A hospital-based surveillance was undertaken between May 2005 and April 2006 to elucidate the contribution of Chandipura virus (CHPV) to acute viral encephalitis cases in children, seroconversion in recovered cases and to compare the seroprevalences of anti-CHPV IgM and N antibodies in areas reporting cases with those without any case of acute viral encephalitis. During this period, 90 cases of acute encephalitis were hospitalized in the pediatric wards of Mahatma Gandhi Memorial (MGM) Hospital, Warangal. There were 49 deaths (Case Fatality Rate, i.e., CFR of 54.4%). Clinical samples and records were obtained from 52 suspected cases. The cases were below 15 years, majority in 0-4 years (35/52, 67.3%). Computerized tomography (CT) scans and cerebro-spinal fluid (CSF) picture favored viral etiology. No neurological sequelae were observed. CHPV etiology was detected in 25 cases (48.1%, n = 52; RNA in 20, IgM in 3 and N antibody seroconversion in 2). JEV etiology was detected in 5 cases (IgM in 4 cases and seroconversion in 1 case). Anti-CHPV IgM seroprevalence in contacts (26/167, 15.6%) was significantly higher (P &lt; 0.05) than in non-contacts (11/430, 2.6%); which was also observed in children &lt; 15 years (19/90, 21.1% vs. 3/109, 2.7%). Anti-CHPV N antibody seroprevalence in &lt;15 years contacts (66/90, 73.3%) and non-contacts (77/109, 70.6%) was significantly lower (P &lt; 0.05) than in contacts (75/77, 97.4%) and non-contacts (302/321, 94.1%) more than 15 years respectively. CHPV appears to be the major cause of acute viral encephalitis in children in endemic areas during early monsoon months