128 research outputs found
Multivalent helix mimetics for PPI-inhibition.
The exploitation of multivalent ligands for the inhibition of protein-protein interactions has not yet been explored as a supramolecular design strategy. This is despite the fact that protein-protein interactions typically occur within the context of multi-protein complexes and frequently exploit avidity effects or co-operative binding interactions to achieve high affinity interactions. In this paper we describe preliminary studies on the use of a multivalent N-alkylated aromatic oligoamide helix mimetic for inhibition of p53/hDM2 and establish that protein dimerisation is promoted, rather than enhanced binding resulting from a higher effective concentration of the ligand. This journal i
Interaction of an extended series of N-substituted di(2-picolyl)amine derivatives with copper(II). Synthetic, structural, magnetic and solution studies
Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models
We attached the pathogen associated molecular pattern Kdo2-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo
The potential of ion mobility mass spectrometry for tuning synthetic host guest systems: A case study using novel zinc(II)dipicolylamine anion sensors
Design and synthesis of bis(Zn(II)-dipicolylamine)-based fluorescent artificial chemosensors for phosphorylated proteins/peptides
Ratiometric fluorescence detection of a tag fused protein using the dual-emission artificial molecular probe
Label-free, real-time glycosyltransferase assay based on a fluorescent artificial chemosensor
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