Huge Transverse Magnetization in the Field-Induced Phase of the Antiferromagnetic Molecular Wheel CsFe8

The 1H-NMR spectrum and nuclear relaxation rate 1/T_1 in the antiferromagnetic wheel CsFe8 were measured to characterize the previously observed magnetic field-induced low-temperature phase around the level crossing at 8 T. The data show that the phase is characterized by a huge staggered transverse polarization of the electronic Fe spins, and the opening of a gap, providing microscopic evidence for the interpretation of the phase as a field-induced magneto-elastic instability.Comment: 5 pages, 4 figures, REVTEX4, to appear in PR

Exchange Interactions and High-Energy Spin States in Mn_12-acetate

We perform inelastic neutron scattering measurements on the molecular nanomagnet Mn_12-acetate to measure the excitation spectrum up to 45meV (500K). We isolate magnetic excitations in two groups at 5-6.5meV (60-75K) and 8-10.5meV (95-120K), with higher levels appearing only at 27meV (310K) and 31meV (360K). From a detailed characterization of the transition peaks we show that all of the low-energy modes appear to be separate S = 9 excitations above the S = 10 ground state, with the peak at 27meV (310K) corresponding to the first S = 11 excitation. We consider a general model for the four exchange interaction parameters of the molecule. The static susceptibility is computed by high-temperature series expansion and the energy spectrum, matrix elements and ground-state spin configuration by exact diagonalization. The theoretical results are matched with experimental observation by inclusion of cluster anisotropy parameters, revealing strong constraints on possible parameter sets. We conclude that only a model with dominant exchange couplings J_1 ~ J_2 ~ 5.5meV (65K) and small couplings J_3 ~ J_4 ~ 0.6meV (7K) is consistent with the experimental data.Comment: 17 pages, 12 figure

Estimating Be Star Disk Radii using H-alpha Emission Equivalent Widths

We present numerical models of the circumstellar disks of Be stars, and we describe the resulting synthetic H-alpha emission lines and maps of the wavelength-integrated emission flux projected onto the sky. We demonstrate that there are monotonic relationships between the emission line equivalent width and the ratio of the angular half-width at half maximum of the projected disk major axis to the radius of the star. These relationships depend mainly upon the temperatures of the disk and star, the inclination of the disk normal to the line of sight, and the adopted outer boundary for the disk radius. We show that the predicted H-alpha disk radii are consistent with those observed directly through long baseline interferometry of nearby Be stars (especially once allowance is made for disk truncation in binaries and for dilution of the observed H-alpha equivalent width by continuum disk flux in the V-band).Comment: 12 pages, 2 figures, ApJL in pres

The effect of neoadjuvant therapy on PD-L1 expression and CD8+lymphocyte density in non-small cell lung cancer.

PD-L1 expression is the routine clinical biomarker for the selection of patients to receive immunotherapy in non-small cell lung cancer (NSCLC). However, the application and best timing of immunotherapy in the resectable setting is still under investigation. We aimed to study the effect of chemotherapy on PD-L1 expression and tumor infiltrating lymphocytes (TILs), which is to date still poorly understood. Our retrospective, single-centre neoadjuvant cohort comprised 96 consecutive patients with NSCLC resected 2000-2016 after neoadjuvant therapy, including paired diagnostic chemo-naïve specimens in 53 cases. A biologically matched surgical cohort of 114 primary resected cases was included. PD-L1 expression, CD8 + TILs density and tertiary lymphoid structures were assessed on whole slides and correlated with clinico-pathological characteristics and survival. Seven/53 and 12/53 cases had lower respectively higher PD-L1 expressions after neoadjuvant therapy. Most cases (n = 34) showed no changes in PD-L1 expression, the majority of these harboring PD-L1 < 1% in both samples (21/34 [61.8%]). Although CD8 + TILs density was significantly higher after chemotherapy (p = 0.031) in resections compared to diagnostic biopsies, this might be due to sampling and statistical bias. No difference in PD-L1 expression or CD8 + TILs density was detected when comparing the neoadjuvant and surgical cohort. In univariable analyses, higher CD8 + TILs density, higher numbers of tertiary lymphoid structures but not PD-L1 expression were significantly associated with longer survival. Increased PD-L1 expression after neoadjuvant chemotherapy was not significantly associated with shorter 5-year survival, but the number of cases was very low. In multivariable analysis, only pT category and age remained independent prognostic factors. In summary, PD-L1 expression was mostly unchanged after neoadjuvant chemotherapy compared to diagnostic biopsies. The sample size of cases with changed PD-L1 expression was too small to draw conclusions on any prognostic value

A prognostic score for non-small cell lung cancer resected after neoadjuvant therapy in comparison with the tumor-node-metastases classification and major pathological response.

Studies validating the prognostic accuracy of the tumor-node-metastases (TNM) classification in patients with lung cancer treated by neoadjuvant therapy are scarce. Tumor regression, particularly major pathological response (MPR), is an acknowledged prognostic factor in this setting. We aimed to validate a novel combined prognostic score. This retrospective single-center study was conducted on 117 consecutive patients with non-small cell lung cancer resected after neoadjuvant treatment at a Swiss University Cancer Center between 2000 and 2016. All cases were clinicopathologically re-evaluated. We assessed the prognostic performance of a novel prognostic score (PRSC) combining T-category, lymph node status, and MPR, in comparison with the eighth edition of the TNM classification (TNM8), the size adapted TNM8 as proposed by the International Association for the Study of Lung Cancer (IASLC) and MPR alone. The isolated ypT-category and the combined TNM8 stages accurately differentiated overall survival (OS, stage p = 0.004) and disease-free survival (DFS, stage p = 0.018). Tumor regression had a prognostic impact. Optimal cut-offs for MPR emerged as 65% for adenocarcinoma and 10% for non-adenocarcinoma and were statistically significant for survival (OS p = 0.006, DFS p < 0.001). The PRSC differentiated between three prognostic groups (OS and DFS p < 0.001), and was superior compared to the stratification using MPR alone or the TNM8 systems, visualized by lower Akaike (AIC) and Bayesian information criterion (BIC) values. In the multivariate analyses, stage III tumors (HR 4.956, p = 0.003), tumors without MPR (HR 2.432, p = 0.015), and PRSC high-risk tumors (HR 5.692, p < 0.001) had significantly increased risks of occurring death. In conclusion, we support 65% as the optimal cut-off for MPR in adenocarcinomas. TNM8 and MPR were comparable regarding their prognostic significance. The novel prognostic score performed distinctly better regarding OS and DFS

Introducing BAX: a database for X-ray clusters and groups of galaxies

We present BAX, Base de Donnees Amas de Galaxies X (http://webast.ast.obs-mip.fr/bax), a multi-wavelength database dedicated to X-ray clusters and groups of galaxies allowing detailed information retrieval. BAX is designed to support astronomical research by providing access to published measurements of the main physical quantities and to the related bibliographic references: basic data stored in the database are cluster/group identifiers, equatorial coordinates, redshift, flux, X-ray luminosity (in the ROSAT band) and temperature, and links to additional linked parameters (in X-rays, such as spatial profile parameters, as well as SZ parameters of the hot gas, lensing measurements,and data at other wavelengths, such as optical and radio). The clusters and groups in BAX can be queried by the basic parameters as well as the linked parameters or combinations of these. We expect BAX to become an important tool for the astronomical community. BAX will optimize various aspects of the scientific analysis of X-ray clusters and groups of galaxies, from proposal planning to data collection, interpretation and publication, from both ground based facilities like MEGACAM (CFHT), VIRMOS (VLT) and space missions like XMM-Newton, Chandra and Planck.Comment: Accepted for publication in Astronomy and Astrophysics Journal. Contains 4 pages and 1 figur

II.5 Where to find the CoRoT data?

This book is dedicated to all the people interested in the CoRoT mission and the beautiful data that were delivered during its six year duration. Either amateurs, professional, young or senior researchers, they will find treasures not only at the time of this publication but also in the future twenty or thirty years. It presents the data in their final version, explains how they have been obtained, how to handle them, describes the tools necessary to understand them, and where to find them. It also highlights the most striking first results obtained up to now. CoRoT has opened several unexpected directions of research and certainly new ones still to be discovered

The heavily polluted atmosphere of the DAZ white dwarf GALEX J193156.8+011745

We report on the discovery of a new heavily polluted white dwarf. The DAZ white dwarf GALEX J193156.8+011745 was identified in a joint GALEX/GSC survey of ultraviolet-excess objects. Optical spectra obtained at ESO NTT show strong absorption lines of magnesium and silicon and a detailed abundance analysis based on VLT-Kueyen UVES spectra reveal super-solar abundances of silicon and magnesium, and near-solar abundances of oxygen, calcium, and iron. The overall abundance pattern bears the signature of ongoing accretion onto the white dwarf atmosphere. The infrared spectral energy distribution shows an excess in the H and K bands likely associated with the accretion source.Comment: Accepted for publication in MNRAS Letter