METHOD FOR DETERMINING HYDRAULIC RESISTANCE DURING

In the article, pulsating fluid flows in tubes with changing walls, which are of great importance in biological mechanics, in particular, in the flow of blood in the arterial vessel, are investigated. The solution of the problem obtained formulas for the distribution of pressure gradient, velocity and flow rate. Impedance method analyzed the increase in hydraulic resistance depending on the frequency of oscillation. It was found that with large values 2 of hydraulic resistance grow with growth 2 . For crowding out the same flow rates, for small and with large values of the vibrational number or frequency, the energy input is different. Since for small values of the oscillatory number, fluctuations in the flow rate of the fluid fluctuate in the same phase with the oscillation of the pressure gradient, and for large values of this number, the oscillation of the phase of the fluid flow is shifted by 0 90 degrees ELECTRONIC JOURNAL OF CENTRAL ASIAN PROBLEMS OF MODERN SCENCE AND EDUCATION. MARCH, 2019-I ISSN 2181-9750 11 than fluctuations in the pressure gradient. In addition, for large values of the vibrational number, a tenfold size increases the maximum amplitude of the pressure gradient, relatively, than at low frequencies. This feature leads to an increase in the energy cost of pumping fluid due to wall oscillatio

Pathomorphological Changes in Poultry Pasteurellios, Pullorosis and Colibacteriosis Diseases

The organism of chicken infected with individual pathogens exhibits relatively simple patho-anatomical modifications in the presence of two or three separate bacterial pathogens. Because it is highly challenging to differentiate between mixed bacterial infections based just on clinical symptoms, pathologoanatomical examination and distinction are preferred. These disorders will be accurately diagnosed promptly and without delay if the pathologo-anatomical investigations are properly examined, and preventive measures will be consistently applied

Mathematical model describing erythrocyte sedimentation rate. Implications for blood viscosity changes in traumatic shock and crush syndrome

BACKGROUND: The erythrocyte sedimentation rate (ESR) is a simple and inexpensive laboratory test, which is widespread in clinical practice, for assessing the inflammatory or acute response. This work addresses the theoretical and experimental investigation of sedimentation a single and multiple particles in homogeneous and heterogeneous (multiphase) medium, as it relates to their internal structure (aggregation of solid or deformed particles). METHODS: The equation system has been solved numerically. To choose finite analogs of derivatives we used the schemes of directional differences. RESULTS: (1) Our model takes into account the influence of the vessel wall on group aggregation of particles in tubes as well as the effects of rotation of particles, the constraint coefficient, and viscosity of a mixture as a function of the volume fraction. (2) This model can describe ESR as a function of the velocity of adhesion of erythrocytes; (3) Determination of the ESR is best conducted at certain time intervals, i.e. in a series of periods not exceeding 5 minutes each; (4) Differential diagnosis of various diseases by means of ESR should be performed using the aforementioned timed measurement of ESR; (5) An increase in blood viscosity during trauma results from an increase in rouleaux formation and the time-course method of ESR will be useful in patients with trauma, in particular, with traumatic shock and crush syndrome. CONCLUSION: The mathematical model created in this study used the most fundamental differential equations that have ever been derived to estimate ESR. It may further our understanding of its complex mechanism

МЕДИКО-БИОЛОГИЧЕСКИЕ ИССЛЕДОВАНИЯ ПО НЕЙТРОН-ЗАХВАТНОЙ ТЕРАПИИ НА АТОМНОМ РЕАКТОРЕ ИЯФ АН РУз

In article are presented the devices and characteristics of channel of epithermal neutrons created on nuclear reactor WWR-SM INP AS of RUz for medical and biologic researches. Realized medical and biologic researches on neutroncapture therapy are discussed. Developed for treatment of radio resistant malignant tumors the Gadolinium neutron capture therapy (GdNCT) is based on the nuclear capture and reactions that occur when 155Gd and 157Gd, which are nonradioactive constituents of natural elemental gadolinium, are irradiated by thermal neutrons with low energy 0.025 eV. In this article, results of scientific researches on development GdNCT in Uzbekistan are presented. The beam of epithermal neutrons with characteristics satisfying the all requirements of IAEA was received. Neutron kerma for biological tissues Kbt n=1,35•10–4 Gr/s and for 1 mg natural gadolinium in 1 g of biological tissues KGd n = 3,1•10–7 Gr/s for this beam was calculated. As gadolinium delivery agent the well-known pharmacological preparation Magnevist was chosen. For absorbed dose calculation, the Magnevist pharmacokinetics was studied after intratumoral injection in mice and intramuscular injection in rats. Results of researches of influence epithermal neutrons beam on binding ability of transport proteins of human blood, on tumor cells С-180 at mice and on surgical material of human stomach adenocarcinoma are presented. Planned scientific researches with application of this beam in Uzbekistan are summarized.В работе представлены устройство и характеристики эпитеплового нейтронного канала, созданного на атомном реакторе ВВР-СМ ИЯФ АН РУз для медико-биологических исследований. Обсуждаются проводимые медико-биологические исследования по нейтрон-захватной терапии. В этой статье представлены результаты научных исследований по разработке GdNCT в Узбекистане. Был получен пучок эпитепловых нейтронов с характеристиками, удовлетворяющими всем требованиям МАГАТЭ. А также, была вычислена керма нейтрона для биологических тканей Kbt n=1,35•10–4 Гр/с и 1 мкг природного гадолиния в 1 г биологической ткани KGd n = 3,1•10–7 Гр/с для этого пучка. Известный фармакологический препарат Магневист (Magnevist) выбран в качестве средства доставки гадолиния. Для расчета поглощенной дозы, фармакокинетика Магневист была изучена после внутриопухолевой инъекции у мышей и внутримышечного введения у крыс. Были представлены результаты исследований влияния эпитепловых нейтронов пучка на связывающей способности транспортных белков крови человека, на опухолевых клетках С-180 у мышей и на хирургических материалах человеческого аденокарциномы желудка. Подведен итог планируемых научных исследований с применением этого пучка в Узбекистане

Surgical outcomes in patients with drug-resistant bilateral temporal lobe epilepsy confirmed via magnetic resonance imaging

Introduction. In patients with drug-resistant temporal lobe epilepsy (TLE), surgical treatment is aimed to resect an epileptogenic zone (EZ) followed by seizure control. Despite complicated EZ location, surgical resection should be considered as a treatment of choice in bilateral TLE. Objective: to evaluate surgical outcomes and factors contributing to outcomes in patients with drug-resistant bilateral TLE confirmed via magnetic resonance imaging. Materials and methods. The study included patients with unilateral (n = 50) and bilateral (n = 50) temporal lobe involvement. The results of surgical treatment were evaluated according to the classification of J. Engel (1993). Results. Favorable outcomes of surgical treatment (Engel I and Engel II) in the group with unilateral temporal lobe involvement were found in 98% of patients after 12 months, in 88% after 24 months, and in 100% after 48 and 60 months after surgery. In the group with bilateral temporal lobe involvement outcomes of surgical treatment were favorable in 41% of patients after 12 months, in 50% after 24 months, in 39% after 48 months, and in 50% of patients after 60 months post-surgery. Conclusion. Early onset, burdened perinatal history, and MRI-confirmed left temporal lobe involvement contribute to the poor outcome (Engel III and Engel IV) in the bilateral TLE group. Engel I outcomes were more common in the patients with unilateral TLE while Engel IIIV outcomes were more common in the patients with bilateral TLE

METHOD FOR DETERMINING HYDRAULIC RESISTANCE DURING

In the article, pulsating fluid flows in tubes with changing walls, which are of great importance in biological mechanics, in particular, in the flow of blood in the arterial vessel, are investigated. The solution of the problem obtained formulas for the distribution of pressure gradient, velocity and flow rate. Impedance method analyzed the increase in hydraulic resistance depending on the frequency of oscillation. It was found that with large values 2 of hydraulic resistance grow with growth 2 . For crowding out the same flow rates, for small and with large values of the vibrational number or frequency, the energy input is different. Since for small values of the oscillatory number, fluctuations in the flow rate of the fluid fluctuate in the same phase with the oscillation of the pressure gradient, and for large values of this number, the oscillation of the phase of the fluid flow is shifted by 0 90 degrees ELECTRONIC JOURNAL OF CENTRAL ASIAN PROBLEMS OF MODERN SCENCE AND EDUCATION. MARCH, 2019-I ISSN 2181-9750 11 than fluctuations in the pressure gradient. In addition, for large values of the vibrational number, a tenfold size increases the maximum amplitude of the pressure gradient, relatively, than at low frequencies. This feature leads to an increase in the energy cost of pumping fluid due to wall oscillatio

Colorectal cancer epidemiology: world trends and incidence of colon cancer in the Republic of Uzbekistan in 2012–2017

Objective: epidemiological evaluation of global trends in colorectal cancer and assessment of colon cancer incidence in the Republic of Uzbekistan in 2012–2017.Materials and methods. We used GLOBOCAN data to analyze the situation with colorectal cancer worldwide. We also assessed the incidence of colon cancer, trends, and mean age of patients (by years) registered in the Republic of Uzbekistan. This article emphasizes the need for epidemiological studies of colorectal cancer in Uzbekistan.Results. World trends in colorectal cancer incidence and mortality indicate that these parameters vary across different regions and depend on the economic situation. There are also some sex differences: men are more likely to develop colorectal cancer than women (male to female ratio 1.25:1.0). The number of patient died of colorectal cancer is growing; the male to female ratio is 1.22:1.0.Conclusions. Our assessment of epidemiological situation of colon cancer in the Republic of Uzbekistan demonstrated that its incidence tends to increase, which necessitates further research evaluating regional differences and risk factors for colorectal cancer

Intervention of Bacterial Diseases in Poultry

The organism of chicken infected with individual pathogens exhibits relatively simple pathoanatomical modifications in the presence of two or three separate bacterial pathogens. It is advised to examine these disorders pathologically because it might be quite challenging to separate these diseases from one another based just on clinical symptoms. Bacteriological infections in poultry have extremely complicated clinical symptoms and pathomorphological modifications that set them apart from other illnesses. However, if the pathologoanatomical investigations are thoroughly examined, the diseases will be accurately detected in time, making it feasible to start preventing them right away

Intervention of Bacterial Diseases in Poultry

The organism of chicken infected with individual pathogens exhibits relatively simple pathoanatomical modifications in the presence of two or three separate bacterial pathogens. It is advised to examine these disorders pathologically because it might be quite challenging to separate these diseases from one another based just on clinical symptoms. Bacteriological infections in poultry have extremely complicated clinical symptoms and pathomorphological modifications that set them apart from other illnesses. However, if the pathologoanatomical investigations are thoroughly examined, the diseases will be accurately detected in time, making it feasible to start preventing them right away

Comparison of the results for calculation of vortex currents after sudden expansion of the pipe with different diameters

In this work, a numerical study of a sharply expanding highly swirling flow is carried out using v2-f models based on the Comsol Multiphysics 5.6 software package and a two-fluid turbulence model. The results obtained are compared with known experimental data with different pipe diameters. The purpose of this work is to test the ability of models to describe anisotropic turbulence. It is shown that the two-fluid model is more suitable for studying such flows