17,377 research outputs found
An improvement in support vector machine classification model using grey relational analysis for cancer diagnosis
To further improve the accuracy of classifier for cancer diagnosis, a hybrid model called GRA-SVM which comprises Support Vector Machine classifier and filter feature selection Grey Relational Analysis is proposed and tested against Wisconsin Breast Cancer Dataset (WBCD) and BUPA Disorder Dataset. The performance of GRA-SVM is compared to SVM’s in terms of accuracy, sensitivity, specificity and Area under Curve (AUC). The experimental results reveal that GRA-SVM improves the SVM accuracy of about 0.48 by using only two features for the WBCD dataset. For BUPA dataset, GRA-SVM improves the SVM accuracy of about 0.97 by using four features. Besides improving the accuracy performance, GRA-SVM also produces a ranking scheme that provides information about the priority of each feature. Therefore, based on the benefits gained, GRA-SVM is recommended as a new approach to obtain a better and more accurate result for cancer diagnosis
Compressible primitive equation: formal derivation and stability of weak solutions
We present a formal derivation of a simplified version of Compressible
Primitive Equations (CPEs) for atmosphere modeling. They are obtained from
-D compressible Navier-Stokes equations with an \emph{anisotropic viscous
stress tensor} where viscosity depends on the density. We then study the
stability of the weak solutions of this model by using an intermediate model,
called model problem, which is more simple and practical, to achieve the main
result
Antenatal atazanavir: a retrospective analysis of pregnancies exposed to atazanavir.
INTRODUCTION: There are few data regarding the tolerability, safety, or efficacy of antenatal atazanavir. We report our clinical experience of atazanavir use in pregnancy.
METHODS: A retrospective medical records review of atazanavir-exposed pregnancies in 12 London centres between 2004 and 2010.
RESULTS: There were 145 pregnancies in 135 women: 89 conceived whilst taking atazanavir-based combination antiretroviral therapy (cART), "preconception" atazanavir exposure; 27 started atazanavir-based cART as "first-line" during the pregnancy; and 29 "switched" to an atazanavir-based regimen from another cART regimen during pregnancy. Gastrointestinal intolerance requiring atazanavir cessation occurred in five pregnancies. Self-limiting, new-onset transaminitis was most common in first-line use, occurring in 11.0%. Atazanavir was commenced in five switch pregnancies in the presence of transaminitis, two of which discontinued atazanavir with persistent transaminitis. HIV-VL < 50 copies/mL was achieved in 89.3% preconception, 56.5% first-line, and 72.0% switch exposures. Singleton preterm delivery (<37 weeks) occurred in 11.7% preconception, 9.1% first-line, and 7.7% switch exposures. Four infants required phototherapy. There was one mother-to-child transmission in a poorly adherent woman.
CONCLUSIONS: These data suggest that atazanavir is well tolerated and can be safely prescribed as a component of combination antiretroviral therapy in pregnancy
On stable higher spin states in Heterotic String Theories
We study properties of 1/2 BPS Higher Spin states in heterotic
compactifications with extended supersymmetry. We also analyze non BPS Higher
Spin states and give explicit expressions for physical vertex operators of the
first two massive levels. We then study on-shell tri-linear couplings of these
Higher Spin states and confirm that BPS states with arbitrary spin cannot decay
into lower spin states in perturbation theory. Finally, we consider scattering
of vector bosons off higher spin BPS states and extract form factors and
polarization effects in various limits.Comment: 38 page
Relativistic ejecta from XRF 060218 and the rate of cosmic explosions
Over the last decade, long-duration gamma-ray bursts (GRBs) including the
subclass of X-ray flashes (XRFs) have been revealed to be a rare variety of
Type Ibc supernova (SN). While all these events result from the death of
massive stars, the electromagnetic luminosities of GRBs and XRFs exceed those
of ordinary Type Ibc SNe by many orders of magnitude. The essential physical
process that causes a dying star to produce a GRB or XRF, and not just an SN,
remains the crucial open question. Here we present radio and X-ray observations
of XRF 060218 (associated with SN 2006aj), the second nearest GRB identified
to-date, which allow us to measure its total energy and place it in the larger
context of cosmic explosions. We show that this event is 100 times less
energetic but ten times more common than cosmological GRBs. Moreover, it is
distinguished from ordinary Type Ibc SNe by the presence of 10^48 erg coupled
to mildly-relativistic ejecta, along with a central engine (an accretion-fed,
rapidly rotating compact source) which produces X-rays for weeks after the
explosion. This suggests that the production of relativistic ejecta is the key
physical distinction between GRBs/XRFs and ordinary SNe, while the nature of
the central engine (black hole or magnetar) may distinguish typical bursts from
low-luminosity, spherical events like XRF 060218.Comment: To appear in Nature on August 31 2006 (15 pages, 3 figures, 1 table,
including Supplementary Information
An optical supernova associated with the X-ray flash XRF 060218
Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae
that are more luminous than average and that eject material at very high
velocities. Less-luminous supernovae were not hitherto known to be associated
with GRBs, and therefore GRB-supernovae were thought to be rare events. Whether
X-ray flashes - analogues of GRBs, but with lower luminosities and fewer
gamma-rays - can also be associated with supernovae, and whether they are
intrinsically 'weak' events or typical GRBs viewed off the axis of the burst,
is unclear. Here we report the optical discovery and follow-up observations of
the type Ic supernova SN 2006aj associated with X-ray flash XRF 060218.
Supernova 2006aj is intrinsically less luminous than the GRB-supernovae, but
more luminous than many supernovae not accompanied by a GRB. The ejecta
velocities derived from our spectra are intermediate between these two groups,
which is consistent with the weakness of both the GRB output and the supernova
radio flux. Our data, combined with radio and X-ray observations, suggest that
XRF 060218 is an intrinsically weak and soft event, rather than a classical GRB
observed off-axis. This extends the GRB-supernova connection to X-ray flashes
and fainter supernovae, implying a common origin. Events such as XRF 060218 are
probably more numerous than GRB-supernovae.Comment: Final published versio
Derivation of Del180 from sediment core log data\u27 Implications for millennial-scale climate change in the Labrador Sea
Sediment core logs from six sediment cores in the Labrador Sea show millennial-scale climate variability during the last glacial by recording all Heinrich events and several major Dansgaard-Oeschger cycles. The same millennial-scale climate change is documented for surface water δ18O records of Neogloboquadrina pachyderma (left coiled); hence the surface water δ18O record can be derived from sediment core logging by means of multiple linear regression, providing a paleoclimate proxy record at very high temporal resolution (70 years). For the Labrador Sea, sediment core logs contain important information about deepwater current velocities and also reflect the variable input of ice-rafted debris from different sources as inferred from grain-size analysis, the relation of density and P wave velocity, and magnetic susceptibility. For the last glacial, faster deepwater currents, which correspond to highs in sediment physical properties, occurred during iceberg discharge and lasted from several centuries to a few millennia. Those enhanced currents might have contributed to increased production of intermediate waters during times of reduced production of North Atlantic Deep Water. Hudson Strait might have acted as a major supplier of detrital carbonate only during lowered sea level (greater ice extent). During coldest atmospheric temperatures over Greenland, deepwater currents increased during iceberg discharge in the Labrador Sea, then surface water freshened shortly thereafter, while the abrupt atmospheric temperature rise happened after a larger time lag of ≥ 1 kyr. The correlation implies a strong link and common forcing for atmosphere, sea surface, and deep water during the last glacial at millennial timescales but decoupling at orbital timescales
Global organization of metabolic fluxes in the bacterium, Escherichia coli
Cellular metabolism, the integrated interconversion of thousands of metabolic
substrates through enzyme-catalyzed biochemical reactions, is the most
investigated complex intercellular web of molecular interactions. While the
topological organization of individual reactions into metabolic networks is
increasingly well understood, the principles governing their global functional
utilization under different growth conditions pose many open questions. We
implement a flux balance analysis of the E. coli MG1655 metabolism, finding
that the network utilization is highly uneven: while most metabolic reactions
have small fluxes, the metabolism's activity is dominated by several reactions
with very high fluxes. E. coli responds to changes in growth conditions by
reorganizing the rates of selected fluxes predominantly within this high flux
backbone. The identified behavior likely represents a universal feature of
metabolic activity in all cells, with potential implications to metabolic
engineering.Comment: 15 pages 4 figure
Awareness and utilization of HIV testing and prevention services among female sex workers in Dnipro, Ukraine: implications for prevention program strengthening from the dynamics study
INTRODUCTION: Approximately 240,000 people live with HIV in Ukraine, concentrated among key populations, including sex workers. Non-governmental organizations (NGOs) play an important role in the funding and delivery of HIV testing and prevention services in Ukraine. These services are set within the context of national healthcare reforms as well as ongoing armed conflict. This study seeks to describe and understand the usage of HIV testing and prevention services among sex workers in the eastern Ukrainian city of Dnipro. METHODS: A cross-sectional bio-behavioral survey was administered in September 2017-March 2018 among 560 sex workers working in Dnipro. Descriptive analyses of survey data are presented alongside multivariable logistic regression models identifying factors associated with NGO awareness and HIV testing in the past 12 months; adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) are reported. RESULTS: Sixty-two percent of respondents were aware of NGOs offering HIV services. Sixty-eight percent had tested for HIV in the past 12 months, and 51% of those who reported the location of their most recent test were tested at an NGO. Those with 5-9 years in sex work had greater odds of being aware of NGOs (AOR = 5.5, 95%CI: 3.2-9.7) and testing for HIV (AOR = 3.4, 95%CI: 2.0-6.0) compared to those new to the profession. Contact with outreach workers was strongly associated with increased odds of testing (AOR = 13.0, 95%CI: 7.0-24.0). Sex workers in "offices" (brothel-like venues) reported higher odds of testing than all other workplaces, while those in entertainment venues (AOR = 0.3, 95%CI: 0.2-0.5) and public places (AOR = 0.2, 95%CI: 0.1-0.3) reported lower rates. Receiving prevention services, such as free condoms, was associated with increased testing (AOR = 16.9, 95%CI: 9.7-29.3). DISCUSSION: NGOs in Dnipro, Ukraine play an important role in HIV testing and prevention for women involved in sex work. However, focused efforts should be placed on supporting access to these services for women that are newer to sex work, and those working in entertainment venues or public places. Outreach workers appear to support access to HIV prevention information and supplies and facilitate linkages to HIV testing for sex workers
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