44 research outputs found
Using TRAILER tool for Managing Informal Learning in academic and professional contexts: the learnersā perspective
Using TRAILER tool for Managing Informal Learning in academic and professional contexts: the learnersā perspective
Viegas, C., Marques, A., Alves, G., Zangrando, V., Galanis, N., Brouns, F., Janssen, J., Waszkiewicz, E., Mykowska, A., Gonzalez, M., Holgado, A., & GarcĆa-PenĢalvo, F. (2013). Using TRAILER tool for Managing Informal Learning in academic and professional contexts: the learnersā perspective. In F. J. GarcĆa-PeƱalvo (Ed.) Proceedings of the 2013 Conference on Technological Ecosystems for Enhancing Multiculturality. (pp. 529-534). November, 14-15, 2013, Salamanca, Spain.Informal Learning plays an important role in everyone's life and
yet we often are unaware of it. The need to keep track of the
knowledge acquired through informal learning is increasing as its
sources become increasingly diverse. This paper presents a study
on a tool developed to help keeping track of learnersā informal
learning, both within academic and professional contexts, This
tool, developed within the European Commission funded
TRAILER project, will further integrate the improvements
suggested by users during the piloting phase. The two studied
contexts were similar regarding the importance and perception of
Informal Learning, but differed concerning tool usage. The overall
idea of managing oneās informal learning was well accepted and
welcomed, which validated the emerging need for a tool with this
purpose.Tagging, Recognition and Acknowledgment of Informal Learning ExpeRiences project (TRAILER) that is funded by the European Commission's Lifelong Learning Programme. Ref. 519141-LLP-1-2011-1-ES-KA3-KA3MP [http://www.trailerproject.eu]. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein
TRAILER: A Tool for Managing Informal Learning
Even though informal learning plays an important role in everyoneās life, not everyone is aware of its importance. These informal activities contribute to the development of self-regulated learning that can help productivity in different environments. As this kind of apprentices grow, the need to keep track of this developed knowledge is becoming vital. This paper presents a study on the perception and usage of a tool that would help keeping track of learnersā informal learning. This study was conducted both within academic and professional contexts and was developed within the European Commission funded TRAILER project. The contexts were similar regarding the importance and perception of informal learning, but differed concerning tool usage and the usefulness of such a platform. The overall idea of managing oneās informal learning was well accepted and welcomed, which validated the emerging need for a tool with this purpose
Tagging, Recognition, Acknowledgment of Informal Learning experiences (TRAILER)
[EN] Learners do not only learn in the institutions, they learn during their live in different contexts, with different resources and from the interaction with different persons. This kind of learning that is not always intentionally carried out is known as informal learning. The application of Information and Communication Technologies to learning and teaching processes facilitates making visible such kind of learning for the institutions. However the nature of formal and non-formal, coursebased, approaches to learning has made it hard to accommodate these informal processes satisfactorily. The project aims to
facilitate first the identification by the learner (as the last responsible of the learning process), and then the recognition by the institution, in dialogue with the learner, of this learning. To do so a methodology and a technological framework to support it have been implemented and tested
Enhancing informal learning recognition through TRAILER project
Conde, M. A., GarcĆa-PenĢalvo, F. J., Zangrando, V.,
GarcĆa-Holgado, A., Seoane-Pardo, A. M., Alier, M., Galanis, N.,
Griffiths, D., Johnson, M., Janssen, J., Brouns, F., Vogten, H.,
Finders, A., Sloep, P. B., Marques, M. A., Viegas, M. C., Alves, G. R.,
Waszkiewicz, E., Mykowska, A., Minovic, M., &
Milovanovic, M. (2013). Enhancing informal learning recognition through
TRAILER project. In F. J. GarcĆa-PeƱalvo, M. Ć. Conde, & D. Griffiths (Eds.), Proceedings of the Workshop on Solutions that Enhance Informal Learning Recognition (WEILER 2013) (pp. 21-30). September, 18, 2013, Paphos, Cyprus. http://ceur-ws.org/Vol-1039/The evolution of new technology and its increasing use, has for some
years been making the existence of informal learning more and more
transparent, especially among young and older adults in both Higher Education
and workplace contexts. However, the nature of formal and non-formal, coursebased,
approaches to learning has made it hard to accommodate these informal
processes satisfactorily. The project aims to facilitate first the identification by
the learner (as the last responsible of the learning process), and then the
recognition by the institution, in dialogue with the learner, of this learning. To
do so a methodology and a technological framework to support it have been
implemented. This project has been tested in several contexts showing that an informal learning dialogue between learners and people in charge
of the institutions is possible.Tagging, Recognition and Acknowledgment of Informal Learning ExpeRiences project (TRAILER) that is funded by the European Commission's Lifelong Learning Programme. Ref. 519141-LLP-1-2011-1-ES-KA3-KA3MP [http:// trailerproject.eu]. This publication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein
A Pathogenic Mechanism in Huntington's Disease Involves Small CAG-Repeated RNAs with Neurotoxic Activity
Huntington's disease (HD) is an autosomal dominantly inherited disorder caused by the expansion of CAG repeats in the Huntingtin (HTT) gene. The abnormally extended polyglutamine in the HTT protein encoded by the CAG repeats has toxic effects. Here, we provide evidence to support that the mutant HTT CAG repeats interfere with cell viability at the RNA level. In human neuronal cells, expanded HTT exon-1 mRNA with CAG repeat lengths above the threshold for complete penetrance (40 or greater) induced cell death and increased levels of small CAG-repeated RNAs (sCAGs), of ā21 nucleotides in a Dicer-dependent manner. The severity of the toxic effect of HTT mRNA and sCAG generation correlated with CAG expansion length. Small RNAs obtained from cells expressing mutant HTT and from HD human brains significantly decreased neuronal viability, in an Ago2-dependent mechanism. In both cases, the use of anti-miRs specific for sCAGs efficiently blocked the toxic effect, supporting a key role of sCAGs in HTT-mediated toxicity. Luciferase-reporter assays showed that expanded HTT silences the expression of CTG-containing genes that are down-regulated in HD. These results suggest a possible link between HD and sCAG expression with an aberrant activation of the siRNA/miRNA gene silencing machinery, which may trigger a detrimental response. The identification of the specific cellular processes affected by sCAGs may provide insights into the pathogenic mechanisms underlying HD, offering opportunities to develop new therapeutic approaches
Triplet repeat RNA structure and its role as pathogenic agent and therapeutic target
This review presents detailed information about the structure of triplet repeat RNA and addresses the simple sequence repeats of normal and expanded lengths in the context of the physiological and pathogenic roles played in human cells. First, we discuss the occurrence and frequency of various trinucleotide repeats in transcripts and classify them according to the propensity to form RNA structures of different architectures and stabilities. We show that repeats capable of forming hairpin structures are overrepresented in exons, which implies that they may have important functions. We further describe long triplet repeat RNA as a pathogenic agent by presenting human neurological diseases caused by triplet repeat expansions in which mutant RNA gains a toxic function. Prominent examples of these diseases include myotonic dystrophy type 1 and fragile X-associated tremor ataxia syndrome, which are triggered by mutant CUG and CGG repeats, respectively. In addition, we discuss RNA-mediated pathogenesis in polyglutamine disorders such as Huntington's disease and spinocerebellar ataxia type 3, in which expanded CAG repeats may act as an auxiliary toxic agent. Finally, triplet repeat RNA is presented as a therapeutic target. We describe various concepts and approaches aimed at the selective inhibition of mutant transcript activity in experimental therapies developed for repeat-associated diseases