Bioremediation and biovalorisation of olive-mill wastes

Olive-mill wastes are produced by the industry of olive oil production, which is a very important economic activity, particularly for Spain, Italy and Greece, leading to a large environmental problem of current concern in the Mediterranean basin. There is as yet no accepted treatment method for all the wastes generated during olive oil production, mainly due to technical and economical limitations but also the scattered nature of olive mills across the Mediterranean basin. The production of virgin olive oil is expanding worldwide, which will lead to even larger amounts of olive-mill waste, unless new treatment and valorisation technologies are devised. These are encouraged by the trend of current environmental policies, which favour protocols that include valorisation of the waste. This makes biological treatments of particular interest. Thus, research into different biodegradation options for olive-mill wastes and the development of new bioremediation technologies and/or strategies, as well as the valorisation of microbial biotechnology, are all currently needed. This review, whilst presenting a general overview, focus critically on the most significant recent advances in the various types of biological treatments, the bioremediation technology most commonly applied and the valorisation options, which together will form the pillar for future developments within this fiel

El reto del envejecimiento y la complejidad farmacoterapéutica en el paciente VIH+

Objective: To describe the current knowledge and management of aging and pharmacotherapeutic complexity in HIV + patients. Method: A review of literature was carried out, including articles, originals or reviews, published in English or Spanish, from 2007 to 2017, which analysed the aging and pharmacotherapeutic complexity in HIV + patients. The terms «Polypharmacy»/«Polifarmacia», «Aging»/«Envejecimiento», «Frailty»/«Fragilidad», «Complejidad Farmacotera péutica»/«Medication Regimen Complexity» and «HIV»/«VIH» were combined. The review was carried out independently by two authors. The degree of agreement, according to the Kappa index, was analysed. Results: A total of 208 references were analysed, including, finally, only 68. An aging of the population and an increase in associated comorbidities have been identified, especially over 50 years-old. Immunological changes similar to those that are generated in a non-infected elderly population have been described. These conditions influencing the prescription of antiretroviral treatment, according to studies identified. In parallel, polypharmacy is increasingly present, being defined exclusively by the concomitant use of five drugs. Pharmacotherapeutic complexity, through the Medication Regimen Complexity Index, has begun to analyse and relate to health outcomes. There has been a need to know and apply concepts already known in non-HIV-aged population, such as deprescription, potentially inappropriate medication, cholinergic risk, although few results are available. Conclusions: There is a growing interest to know about the relationship between HIV and aging. Pharmacotherapeutic complexity is beginning to be used as a pharmacotherapeutic follow-up criterion due to its influence on health outcomes. It is necessary to manage and incorporate new concepts that help pharmacotherapeutic optimization in this population

The central nervous system and sudden cardiac death: What should we know?

The role of the central nervous system in the modulation and precipitation of sudden cardiac death has been a matter of controversy for decades. Establishing a cause-effect relationship in the setting of a cerebro-vascular event has been complex, as patients with stroke usually have risk factors for coronary artery disease as well. This article will review both experimental and clinical evidence relating to the mechanisms that link the central nervous system and the cardiovascular system. Cardiovascular consequences of stroke and epilepsy will be also reviewed

Unidimensional model of the ad-atom diffusion on a substrate submitted to a standing acoustic wave I. Derivation of the ad-atom motion equation

The effect of a standing acoustic wave on the diffusion of an ad-atom on a crystalline surface is theoretically studied. We used an unidimensional space model to study the ad-atom+substrate system. The dynamic equation of the ad-atom, a Generalized Langevin equation, is analytically derived from the full Hamiltonian of the ad-atom+substrate system submitted to the acoustic wave. A detailed analysis of each term of this equation, as well as of their properties, is presented. Special attention is devoted to the expression of the effective force induced by the wave on the ad-atom. It has essentially the same spatial and time dependences as its parent standing acoustic wave

A new model and metaheuristic approach for the energy-based resource-constrained scheduling problem

[EN] This article focuses on obtaining sustainable and energy-efficient solutions for limited resource programming problems. To this end, a model for integrating makespan and energy consumption objectives in multi-mode resource-constrained project scheduling problems (MRCPSP-ENERGY) is proposed. In addition, a metaheuristic approach for the efficient resolution of these problems is developed. In order to assess the appropriateness of theses proposals, the well-known Project Scheduling Problem Library is extended (called PSPLIB-ENERGY) to include energy consumption to each Resource-Constrained Project Scheduling Problem instance through a realistic mathematical model. This extension provides an alternative to the current trend of numerous research works about optimization and the manufacturing field, which require the inclusion of components to reduce the environmental impact on the decision-making process. PSPLIB-ENERGY is available at http://gps.webs.upv.es/psplib-energy/.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was supported by the Spanish Government under the research projects TIN2013-46511-C2-1 and TIN2016-80856-R.Morillo-Torres, D.; Barber, F.; Salido, MA. (2017). A new model and metaheuristic approach for the energy-based resource-constrained scheduling problem. Proceedings of the Institution of Mechanical Engineers Part B Journal of Engineering Manufacture. 1(1):1-13. https://doi.org/10.1177/0954405417711734S1131

Mode-Based versus Activity-Based Search for a Nonredundant Resolution of the Multimode Resource-Constrained Project Scheduling Problem

[EN] This paper addresses an energy-based extension of the Multimode Resource-Constrained Project Scheduling Problem (MRCPSP) called MRCPSP-ENERGY. This extension considers the energy consumption as an additional resource that leads to different execution modes (and durations) of the activities. Consequently, different schedules can be obtained. The objective is to maximize the efficiency of the project, which takes into account the minimization of both makespan and energy consumption. This is a well-known NP-hard problem, such that the application of metaheuristic techniques is necessary to address real-size problems in a reasonable time. This paper shows that the Activity List representation, commonly used in metaheuristics, can lead to obtaining many redundant solutions, that is, solutions that have different representations but are in fact the same. This is a serious disadvantage for a search procedure. We propose a genetic algorithm(GA) for solving the MRCPSP-ENERGY, trying to avoid redundant solutions by focusing the search on the execution modes, by using the Mode List representation. The proposed GA is evaluated on different instances of the PSPLIB-ENERGY library and compared to the results obtained by both exact methods and approximate methods reported in the literature. This library is an extension of the well-known PSPLIB library, which contains MRCPSP-ENERGY test cases.This paper has been partially supported by the Spanish Research Projects TIN2013-46511-C2-1-P and TIN2016-80856-R.Morillo-Torres, D.; Barber, F.; Salido, MA. (2017). Mode-Based versus Activity-Based Search for a Nonredundant Resolution of the Multimode Resource-Constrained Project Scheduling Problem. Mathematical Problems in Engineering. 2017:1-15. https://doi.org/10.1155/2017/4627856S1152017Mouzon, G., Yildirim, M. B., & Twomey, J. (2007). 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International Series in Operations Research & Management Science, 147-178. doi:10.1007/978-1-4615-5533-9_7Józefowska, J., Mika, M., Różycki, R., Waligóra, G., & Węglarz, J. (2001). Annals of Operations Research, 102(1/4), 137-155. doi:10.1023/a:1010954031930Bouleimen, K., & Lecocq, H. (2003). A new efficient simulated annealing algorithm for the resource-constrained project scheduling problem and its multiple mode version. European Journal of Operational Research, 149(2), 268-281. doi:10.1016/s0377-2217(02)00761-0Alcaraz, J., Maroto, C., & Ruiz, R. (2003). Solving the Multi-Mode Resource-Constrained Project Scheduling Problem with genetic algorithms. Journal of the Operational Research Society, 54(6), 614-626. doi:10.1057/palgrave.jors.2601563Zhang, H., Tam, C. M., & Li, H. (2006). Multimode Project Scheduling Based on Particle Swarm Optimization. Computer-Aided Civil and Infrastructure Engineering, 21(2), 93-103. doi:10.1111/j.1467-8667.2005.00420.xJarboui, B., Damak, N., Siarry, P., & Rebai, A. (2008). A combinatorial particle swarm optimization for solving multi-mode resource-constrained project scheduling problems. Applied Mathematics and Computation, 195(1), 299-308. doi:10.1016/j.amc.2007.04.096Li, H., & Zhang, H. (2013). Ant colony optimization-based multi-mode scheduling under renewable and nonrenewable resource constraints. Automation in Construction, 35, 431-438. doi:10.1016/j.autcon.2013.05.030Lova, A., Tormos, P., Cervantes, M., & Barber, F. (2009). An efficient hybrid genetic algorithm for scheduling projects with resource constraints and multiple execution modes. International Journal of Production Economics, 117(2), 302-316. doi:10.1016/j.ijpe.2008.11.002Peteghem, V. V., & Vanhoucke, M. (2010). A genetic algorithm for the preemptive and non-preemptive multi-mode resource-constrained project scheduling problem. European Journal of Operational Research, 201(2), 409-418. doi:10.1016/j.ejor.2009.03.034Węglarz, J., Józefowska, J., Mika, M., & Waligóra, G. (2011). Project scheduling with finite or infinite number of activity processing modes – A survey. European Journal of Operational Research, 208(3), 177-205. doi:10.1016/j.ejor.2010.03.037Kolisch, R., & Hartmann, S. (2006). Experimental investigation of heuristics for resource-constrained project scheduling: An update. European Journal of Operational Research, 174(1), 23-37. doi:10.1016/j.ejor.2005.01.065Debels, D., De Reyck, B., Leus, R., & Vanhoucke, M. (2006). A hybrid scatter search/electromagnetism meta-heuristic for project scheduling. European Journal of Operational Research, 169(2), 638-653. doi:10.1016/j.ejor.2004.08.020Paraskevopoulos, D. C., Tarantilis, C. D., & Ioannou, G. (2012). Solving project scheduling problems with resource constraints via an event list-based evolutionary algorithm. 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Two-state theory of nonlinear Stochastic Resonance

An amenable, analytical two-state description of the nonlinear population dynamics of a noisy bistable system driven by a rectangular subthreshold signal is put forward. Explicit expressions for the driven population dynamics, the correlation function (its coherent and incoherent part), the signal-to-noise ratio (SNR) and the Stochastic Resonance (SR) gain are obtained. Within a suitably chosen range of parameter values this reduced description yields anomalous SR-gains exceeding unity and, simultaneously, gives rise to a non-monotonic behavior of the SNR vs. the noise strength. The analytical results agree well with those obtained from numerical solutions of the Langevin equation.Comment: 4 pages, 1 figur

Xps Study of the Oxidation State of Uranium Dioxide

In this article we report an investigation of the oxidation state of uranium dioxide using X-Ray Photoelectron Spectroscopy, and by comparing to results obtained in previous studies. We find that uranium dioxide in powder appears to share its six valence electrons with the oxygen atoms to form crystalline UO3