Role of magnetic resonance imaging in the evaluation of the popliteus musclotendinous injuries as a part of the posterolateral corner injuries of the knee

Introduction: The popliteus musclotendinous complex is considered to be one of the main stabilizers of the posterolateral corner of the knee having different attachments and variable sites of injuries, the use of MRI helps the radiologists to depict such injuries consistently.Purpose of the study: To study the role of MRI in evaluating the popliteus musclotendinous injuries as a part of the PLCof the knee.Patients and methods: Our study included 15 patients with trauma to the knee undergoing MRI using 1.5 T magnet using the following sequence: Axial, Coronal, sagittal proton density fat sat, T1, T2 and T2 gradient and conventional X-ray/CT [All patients did conventional X-ray Knee (AP and Lateral views), two patients did CT study of the knee].Results: Out of 15 studied patients with PLC injuries, eight (53.33%) patients had popliteus complex injuries, 7 (87.5%) patients showed combined injuries with other posterolateral structures while one (12.5) patient had isolated popliteus musclotendinous complex injury.Conclusion: MRI imaging is crucial in the evaluation of the different sites and patterns of injuries of the popliteus musclotendinous complex when suspecting PLC injury.Keywords: Popliteus muscle, Popliteus tendon, Posterolateral corner, Popliteofibular ligament, MR

Synthesis and antibacterial activity of 3-arylidene chromen-2, 4-dione derivatives

Abstract: Derivatives of 3-arylidene chromen-2, 4-dione 1 were synthesized to be used as a starting material for synthesizing some new fused heterocyclic compounds containing coumarin moiety. When compounds 1 reacted with hydrazine derivatives, hydroxylamine hydrochloride, urea, thiourea, semicarbazide and thiosemicarbazide it gave the corresponding compounds 2-5. Compound 4a, b reacted with methyl iodide in DMF and K2CO3 at room temperature to afford the corresponding 6a, b. All these compounds were screened InVitro for their antibacterial activity

Report on needs and priorities in the field of international cooperation agreements on water management in the target MACs

This report aims to provide a revision of the water related goals within the international agreements joined by the three case study countries,Egypt, Morocco and Tunisia, while emphasizing the critical points that should be developed and reinforced in the near future through an integrated approach for water policies, initiatives and management

Synthesis, characterization and medical efficacy (hepatoprotective and antioxidative) of albendazole-based copper(II) complexes – an experimental and theoretical approach

<div><p>A series of albendazole-based copper(II) complexes with different counter anions, [Cu(Albz)(H₂O)₂](ClO₄)₂ (<b>1</b>), [Cu(Albz)₂(Cl)]Cl·2H₂O (<b>2</b>), [Cu(Albz<b>)</b>₂(NO₃)](NO₃) (<b>3</b>), and [Cu₂(Albz)₂(μ-SO₄)₂(H₂O)₂] (<b>4</b>) (Albz = albendazole), have been synthesized and characterized. Their structures and properties were characterized by elemental analysis, thermal analysis (TGA, DTG and DTA), IR, UV–vis and ESR spectroscopies, cyclic voltammetry, electrical molar conductivity, and magnetic moment measurements. A square-planar geometry is proposed for <b>1</b>, whereas the five-coordinate copper(II) complexes <b>2</b>, <b>3</b>, and <b>4</b> have a square pyramidal geometry. Theoretical calculations (DFT) using B3LYP/6–311 + G(d,p) level of theory corroborated the experimental results to investigate both the drug Albz and its copper(II) complex, <b>1</b>. The hepatoprotective and antioxidative efficacy of Albz and <b>1–4</b> were evaluated against carbon tetrachloride-induced acute hepatotoxicity in rats. Hepatotoxicity in experimental rats was evidenced by significant decrease in the antioxidant enzyme activities (SOD, GSH-S-transfers, and GSH-Rd levels). The results have strong impact for designing anticancer drugs, combined with their potential cytotoxic and antioxidant activities, which can be targeted selectively against cancer cells and increase their therapeutic index and advantages over other anticancer drugs. The DNA cleavage studies of Albz and its copper(II) complexes using genomic DNA indicated that Albz has no role in cleavage of DNA, and only <b>1</b> played a marked role in the DNA cleavage without any external additives.</p></div

Программа спецкурса для студентов 4 курса дневного и заочного форм обучений по спецкурсу "Конституционно-правовая ответственность в Республике Беларусь и зарубежных странах"

The Mediterranean region is characterized by increasing pressures over its natural resources and significant disparities among countries (UNEP/MAP, 2016). The region is considered as one of the most water scarce regions in the World with an average water availability below 1000m3 per capita for most of the countries located in the Southern and Eastern rims of the Mediterranean, and even below 500m3 in many of them (e.g. Algeria, Libya, Tunisia or Jordan). Growing population, irrigation expansion and urbanization are increasing pressures on water resources quantity and quality that will be likely exacerbated by political instability and climate change, reducing available water resources per capita and affecting socio-economic and environmental conditions. In light of this, a number of international initiatives are being developed to ensure sustainable development in the region and contribute to a sustainable management and use of water resources. In this context, the MADFORWATER project tries to address different water resources management issues that include the low availability and use of locally-adapted technologies for wastewater treatment and reuse for irrigation; a lack or inefficiency of economic and regulatory instruments to foster water saving irrigation technologies and practices and water reuse in agriculture; limited capacity building and social acceptance of treated wastewater reuse in agriculture; and, in essence, insufficiently integrated water management strategies. To respond to these challenges, the MADFORWATER project general objective is “to develop an integrated set of technological and management instruments for the enhancement of wastewater treatment, treated wastewater reuse for irrigation and water efficiency in agriculture, with the final aim to reduce water vulnerability in selected basins in Egypt, Morocco and Tunisia” (MADFORWATER Document of Action – part B – page 1).The selected basins, chosen due to their relevance and representativeness for the Mediterranean region in relation to population, GDP, wastewater, hydrology and geographical location, are all subjected to exacerbating water scarcity, and count on high potential to increase wastewater reuse (currently 7% used), (MADFORWATER Document of Action – part B – page 1). This Deliverable (D1.1) “Report on needs and priorities in the field of international cooperation agreements on water management in the target Mediterranean African Countries (MACs)” is part of Work Package 1 (WP1) “Water and water-related vulnerabilities in Egypt, Morocco and Tunisia”. The main objective of this work package is to analyze water stress and water vulnerability in the three MACs, paying special attention to wastewater treatment, water reuse and water efficiency in agriculture and the impacts on food security, socio-economic growth, sustainability of agriculture and environmental protection. For this, D1.1 aims to provide a revision of the water related goals within the international agreements joined by the three case study countries, while emphasizing the critical points that should be developed and reinforced in the near future through an integrated approach for water policies, initiatives and management. It also sets a reference framework and knowledge base for different activities in the MADFORWATER project

Report on needs and priorities in the field of international cooperation agreements on water management in the target MACs

This report aims to provide a revision of the water related goals within the international agreements joined by the three case study countries,Egypt, Morocco and Tunisia, while emphasizing the critical points that should be developed and reinforced in the near future through an integrated approach for water policies, initiatives and management

Regional Flood Frequency Analysis for the River Nile Basin

Regional differences have been investigated in the probabilities of high and low river flow extremes along the river Nile basin in eastern Africa. This has been done on the basis of statistical extreme value analysis applied to about one hundred flow gauging stations spread over the basin. The statistical analysis results have been combined with physical sub-basin characteristics such as topography and land use. The research has been conducted within the framework of the FRIEND/Nile project, which focuses on regional hydrology research cooperation between the main Nile countries (Egypt, Sudan, Ethiopia, Kenya, Tanzania, Uganda) and the Flemish universities. The high- and low-flow statistics developed can be used in water engineering and civil engineering design applications. Of equal importance are the supratechnical research outputs, among which enhancement of water-related transboundary research cooperation in the Nile region. During the course of the project, trust among the researchers and water managers from the different Nile countries gradually increased, data sharing enhanced, and politically sensitive issues (on transboundary water sharing) became debatable.status: publishe

MicroRNA Signatures for circulating CD133-positive cells in hepatocellular carcinoma with HCV infection

<div><p>Aim</p><p>Molecular characterization of the CD133+ stem cells associated with hepatocarinogensis through identifying the expression patterns of specific microRNAs (miRNAs).</p><p>Methods</p><p>We investigated the expression pattern of 13 miRNAs in purified CD133+ cells separated from the peripheral blood of healthy volunteers, chronic hepatitis C (CHC), liver cirrhosis (LC) and hepatocellular carcinoma (HCC) patients a long with bone marrow samples from the healthy volunteers and the LC patients using custom miScript miRNA PCR array.</p><p>Results</p><p>The differential expression of the 13 studied miRNAs in CD133+ cells separated from the HCC patients' peripheral blood compared to the controls revealed that <i>miR-602</i>, <i>miR-181b</i>, <i>miR-101</i>, <i>miR-122</i>, <i>miR-192</i>, <i>miR-125a-5p</i>, and <i>miR-221</i> were significantly up regulated (fold change = 1.8, 1.7, 2, 5.4, 1.6, 2.9 & 1.5 <i>P</i> value = 0.039, 0.0019, 0.0013, 0.0370, 00024, 0.000044 &0.000007 respectively). As for the HCC group compared to the CHC group; <i>miR-602</i>, miR-122, <i>miR-181b</i>, <i>miR-125a-5p</i>, and <i>miR-192</i> were significantly up regulated (fold change = 13, 3.1, 2.8, 1.6 & 1.56, <i>P</i> value = 0.01, 0.001, 0.000004, 0.002 & 0.007 respectively). Upon comparing the HCC group to the LC group; <i>miR-199a-3p</i>, <i>miR-192</i>, <i>miR-122</i>, <i>miR-181b</i>, <i>miR-224</i>, <i>miR-125a-5p</i>, and <i>miR-885-5p</i> were significantly up regulated (fold change = 5, 6.7, 2.3, 3, 2.5, 4.2 & 39.5 <i>P</i> value = 0.001025, 0.000024, 0.000472, 0.000278, 0.000004, 0.000075 & 0.0000001 respectively) whereas <i>miR-22</i> was significantly down regulated (fold change = 0.57 <i>P</i> value = 0.00002). Only, <i>miR-192</i>, <i>miR-122</i>, <i>miR-181b</i> and <i>miR-125a-5p</i> were significant common miRNAs in CD133+ cells of the HCC group compared to the other non-malignant groups.</p><p>Conclusion</p><p>We identified a miRNA panel comprised of four miRNAs (<i>miR-192</i>, <i>miR-122</i>, <i>miR-181b</i> and <i>miR-125a-5p</i>) that may serve as a molecular tool for characterization of the CD133+ cells associated with different stages of hepatocarinogensis. This panel may aid in developing a new target therapy specific for those CD133+ cells.</p></div