Development of a Miniature Electrostatic Accelerometer /MESA/ for low g applications Summary report

Design, fabrication, and testing of miniature digital electrostatic accelerometer for low gravity measurements in spac

Proactive or Reactive? Optimal Management of an Invasive Forest Pest in a Spatial Framework

This paper offers a preliminary investigation into the conditions under which it might be optimal to engage in proactive management of a non-timber forest resource in the presence of an invasive species whose spread is unaffected by management action. Proactive management is defined as treating an uninfected area in order to encourage healthy ecosystem function, given that the arrival of the invasive is inevitable. Inspired by the problem of white pine blister rust in the Rocky Mountain west, the model was solved under varying assumptions concerning the scale of management action, benefit and costs, the discount rate, and uncertainty of spread. Results showed that proactive strategies tended to be optimal when, ceteris paribus, a) more resources are available for treatment; b) the costs of treatment are rapidly increasing in forest health, or conversely, the benefits of healthy and unhealthy stands are relatively similar; and c) the discount rate is low. The introduction of uncertainty did not significantly affect the likelihood of a proactive management strategy being optimal, but did show that the conditional probabilities of infection play important role in the decision of which uninfected stand should be treated if a choice is available to the manager.Crop Production/Industries, Resource /Energy Economics and Policy,

Preventative tele-health supported services for early stage chronic obstructive pulmonary disease: a protocol for a pragmatic randomized controlled trial pilot

Background Chronic Obstructive Pulmonary Disease (COPD) is a prevalent debilitating long term condition. It is the second most common cause of emergency admission to hospital in the UK and remains one of the most costly conditions to treat through acute care. Tele-health monitoring offers potential to reduce the rates of re-hospitalisation and emergency department visits and improve quality of life for people with COPD. However, the current evidence base to support technology adoption and implementation is limited and the resource implications for implementing tele-health in practice can be very high. This trial will employ tele-health monitoring in a preventative capacity for patients diagnosed with early stage COPD following discharge from hospital to determine whether it reduces their need for additional health service support or hospital admission and improves their quality of life. Methods/Design We describe a pilot study for a two arm, one site randomized controlled trial (RCT) to determine the effect of tele-health monitoring on self-management, quality of life and patient satisfaction. Sixty patients who have been discharged from one acute trust with a primary diagnosis of COPD and who have agreed to receive community clinical support following discharge from acute care will be randomly assigned to one of two groups: (a) Tele-health supported Community COPD Service; or (b) Usual Care. The tele-health supported service involves the patient receiving two home visits with a specialist COPD clinician (nurse or physiotherapist) then participating in daily tele-monitoring over an eight week period. Usual care consists of six home visits to the patient by specialist COPD clinicians again over eight successive weeks. Health status and quality of life data for all participants will be measured at baseline, on discharge from the service and at six months post discharge from the service. Discussion The tele-health service under study is a complex service delivered through a collaboration between local authority and health care partners. The implementation of this service demanded significant changes to established working patterns and has been a challenging process requiring considerable planning - a challenge that many providers are likely to face in the future. Trial registration Current Controlled Trials ISRCTN6885601

Predicting the movements of permanently installed electrodes on an active landslide using time-lapse geoelectrical resistivity data only

If electrodes move during geoelectrical resistivity monitoring and their new positions are not incorporated in the inversion, then the resulting tomographic images exhibit artefacts that can obscure genuine time-lapse resistivity changes in the subsurface. The effects of electrode movements on time-lapse resistivity tomography are investigated using a simple analytical model and real data. The correspondence between the model and the data is sufficiently good to be able to predict the effects of electrode movements with reasonable accuracy. For the linear electrode arrays and 2D inversions under consideration, the data are much more sensitive to longitudinal than transverse or vertical movements. Consequently the model can be used to invert the longitudinal offsets of the electrodes from their known baseline positions using only the time-lapse ratios of the apparent resistivity data. The example datasets are taken from a permanently installed electrode array on an active lobe of a landslide. Using two sets with different levels of noise and subsurface resistivity changes, it is found that the electrode positions can be recovered to an accuracy of 4 % of the baseline electrode spacing. This is sufficient to correct the artefacts in the resistivity images, and provides for the possibility of monitoring the movement of the landslide and its internal hydraulic processes simultaneously using electrical resistivity tomography only

Characterising sand and gravel deposits using electrical resistivity tomography (ERT) : case histories from England and Wales

Electrical Resistivity Tomography (ERT) is a rapidly developing geophysical imaging technique that is now widely used to visualise subsurface geological structure, groundwater and lithological variations. It is being increasingly used in environmental and engineering site investigations, but despite its suitability and potential benefits, ERT has yet to be routinely applied by the minerals industry to sand and gravel deposit assessment and quarry planning. The principal advantages of ERT for this application are that it is a cost-effective non-invasive method, which can provide 2D or 3D spatial models of the subsurface throughout the full region of interest. This complements intrusive sampling methods, which typically provide information only at discrete locations. Provided that suitable resistivity contrasts are present, ERT has the potential to reveal mineral and overburden thickness and quality variations within the body of the deposit. Here we present a number of case studies from the UK illustrating the use of 2D and 3D ERT for sand and gravel deposit investigation in a variety of geological settings. We use these case studies to evaluate the performance of ERT, and to illustrate good practice in the application of ERT to deposit investigation. We propose an integrated approach to site investigation and quarry planning incorporating both conventional intrusive methods and ERT

Acoustic emission monitoring of a soil slope: comparisons with continuous deformation measurements

Acoustic emission (AE) has become an established approach to monitor the stability of soil slopes. However, the challenge has been to develop strategies to interpret and quantify deformation behaviour from the measured AE. This paper presents the first comparison of continuous AE (measured using an active waveguide) and continuous subsurface deformation measurements. The active waveguide is installed in a borehole through a slope and comprises a metal waveguide rod or tube with a granular backfill surround. When the host slope deforms, the column of granular backfill also deforms, generating AE that can propagate along the waveguide. This paper presents results from a field trial at a reactivated soil slope in North Yorkshire, UK. The measurements confirm that AE rates generated are directly proportional to the velocity of slope movement (e.g. the AE rate versus velocity relationship determined for a series of slope movement events produced an R 2 value of 0·8) and demonstrate the performance of AE monitoring of active waveguides to provide continuous information on slope displacements and displacement rates with high temporal resolution

Hacia un mejor entendimiento sobre los agricultores custodios y sus roles: percepciones de un estudio de caso en Cachilaya, Bolivia

Esta publicacion es el resultado de una investigacion colaborativa entre Bioversity International y la Fundacion para la Promocion e Investigacion de Productos Andinos (PROINPA). Se ocupa de las cuestiones relativas a la conservacion de la agrobiodiversidad en finca, un campo poco abordado por la investigacion, a pesar de su rol fundamental en el mantenimiento de la diversidad agrícola mundial. Actores estrategicos en la conservacion en las fincas son los agricultores que, por diversas razones, se distinguen de los demas por su contribucion a la conservacion de la diversidad de cultivos. Los llamamos ‘agricultores custodios’, a pesar de que la terminología pueda no ser adecuada para todos los contextos sociales. El entender quienes son los agricultores custodios, su presencia en el territorio, los tipos de cultivos que mantienen, el por que y como lo hacen, así como el adquirir conocimientos sobre los factores culturales, sociales y economicos detras de sus esfuerzos es, para los científicos, un paso muy importante en la elaboracion de estrategias efectivas de conservación en finca. Las entrevistas abiertas y la observacion participante son metodologías utiles para guiar futuros enfoques metodologicos y así avanzar en la comprension de como los roles de los agricultores custodios pueden ser mejor reconocidos, aprovechados y apoyados por la sociedad. Este trabajo ha sido realizado en el marco de un importante proyecto mundial de las Naciones Unidas apoyado por el FIDA y la Comision Europea, que se centra en el desarrollo de enfoques participativos e innovadores para la conservacion en finca de Especies Olvidadas y Subutilizadas (EOS)

Intra-tester and inter-tester reliability of the MicroFET 3 hand-held dynamometer.

Background: The reliability of the MicroFET 3 has not previously been reported in the literature. The aim of this study was to evaluate intra-tester and inter-tester reliability of the MicroFET3 hand-held dynamometer (HHD) in three lower limb muscle groups. Methods: Maximum voluntary isometric contraction (MVIC) of hip extension, knee extension and ankle plantar-flexion were measured in 38 healthy participants (males=18, females= 20) by two testers on separate days using the MicroFET3 HHD. The reliability analysis was carried out using intra-class correlation coefficients (ICCs) to measure association and Band and Altman plots to demonstrate agreement. Results: The results showed that intra-tester reliability was moderate to excellent; with associations ranging from ICC 0.56 - 0.92 and higher agreement for knee and ankle than hip measurements was shown. Inter-tester reliability was lower, with hip and knee associations ranging from ICC 0.60 - 0.66. Ankle measurements intertester associations were particularly low (ICC 0.23 and 0.15). These values would not be considered acceptable for clinical use. Bland and Altman plots used to demonstrate agreement between testers displayed a considerable lack of agreement with discrepancies of up to 150N noted in measurements. Conclusion: The results suggest that the MicroFET3 HHD displayed moderate to excellent intra-tester reliability and poor to moderate inter-tester reliability and agreement with discrepancies noted between muscle groups. While use of this instrument can be recommended when consistently used by a single tester, further reliability analysis should be carried out before this instrument could be recommended for use by different testers in the clinical setting

Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production

STAT3 is a transcription factor implicated in renal fibrotic injury, but the role of STAT3 in mesenchymal stem cell (MSC)-induced renoprotection during renal fibrosis remains unknown. We hypothesized that MSCs protect against obstruction-induced renal fibrosis by downregulating STAT3 activation and STAT3-induced matrix metalloproteinase-9 (MMP-9) expression. Male Sprague-Dawley rats underwent renal arterial injection of vehicle or MSCs (1 × 106/rat) immediately before sham operation or induction of unilateral ureteral obstruction (UUO). The kidneys were harvested after 4 wk and analyzed for collagen I and III gene expression, collagen deposition (Masson's trichrome), fibronectin, α-smooth muscle actin, active STAT3 (p-STAT3), MMP-9, and tissue inhibitor of matrix metalloproteinases 1 (TIMP-1) expression. In a separate arm, the STAT3 inhibitor S3I-201 (10 mg/kg) vs. vehicle was administered to rats intraperitoneally just after induction of UUO and daily for 14 days thereafter. The kidneys were harvested after 2 wk and analyzed for p-STAT3 and MMP-9 expression, and collagen and fibronectin deposition. Renal obstruction induced a significant increase in collagen, fibronectin, α-SMA, p-STAT3, MMP-9, and TIMP-1 expression while exogenously administered MSCs significantly reduced these indicators of obstruction-induced renal fibrosis. STAT3 inhibition with S3I-201 significantly reduced obstruction-induced MMP-9 expression and tubulointerstitial fibrosis. These results demonstrate that MSCs protect against obstruction-induced renal fibrosis, in part, by decreasing STAT3 activation and STAT3-dependent MMP-9 production