Network perspective of histamine related diseases

Histamine is the most pleiotropic biogenic amine. Produced and stored by a limited set of cells—histaminergic neurons, enterochromaffin-like cells, and mast cells—it broadcasts intercellular communication signals to a wide variety of cell types through its tissue-specific receptors. The many molecular interactions of these receptors and other mediators result in complex cellular networks whose alteration result in disease. Therefore, complex diseases map to modules of these cellular networks in the diseasomes. In this communication, we survey the histamine cellular networks to map the histamine diseasome, presenting a network view of the pleiotropy of histamine and its role in several complex diseases.A.A. Moya is a CIBERER fellow. The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain)]. This communication has the support of a travel grant "Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech"

Is emamectin benzoate effective against the different stages of Spodoptera exigua (Hübner) (Lepidoptera, Noctuidae)?

peer-reviewedThis work was partially supported by the Spanish Ministry of Science and Innovation (project AGL 2007-66130-C03-02 to P. Medina). F. Amor and P. Bengochea acknowledge the ministry of Education and Culture and the Technical University of Madrid (UPM) for the doctoral fellowships. Special thanks to Syngenta Agro S.A. for their support.The beet armyworm, Spodoptera exigua (Hübner) (Lepidoptera, Noctuidae), is a major polyphagous pest in greenhouses and open fields worldwide and also a main problem in sweet pepper greenhouses. The effectiveness of the pesticide emamectin benzoate was tested in the laboratory on different stages of S. exigua using different concentrations and uptake routes. After dipping young (48-h-old) S. exigua eggs in emamectin benzoate at 0.5, 1 and 1.5 mg/L a.i. the chemical did not exhibit any ovicidal activity. There was, however, progressive neonate mortality at all concentrations, culminating at 72 hours after hatching, when 100% of the larvae from the treated young eggs died. Second and fourth instar S. exigua larvae did not exhibit significant mortality when exposed to the inert surfaces which were treated. In contrast, ingesting a diet contaminated with 0.5 mg/L a.i. of emamectin benzoate caused 100% mortality in L2 and L4 larvae 24 and 72 hours after ingestion, respectively. The LC50 value of the compound against L4 larvae that fed on sprayed sweet pepper leaves for 24 hours was 0.81 mg/L a.i.. When adults were fed on a solution of 0.5 mg/L a.i., there was a reduction in the female and male lifespan of 29.3% and 55.3%, respectively. Fecundity was reduced by more than 99%. These data suggest that emamectin benzoate is not only a useful insecticide when ingested by beet armyworm larvae but it also has ovolarvicidal and adult activity.Spanish Ministry of Science and Innovatio

Rocky Mountain Spotted Fever, Panama

We describe a fatal pediatric case of Rocky Mountain spotted fever in Panama, the first, to our knowledge, since the 1950s. Diagnosis was established by immunohistochemistry, PCR, and isolation of Rickettsia rickettsii from postmortem tissues. Molecular typing demonstrated strong relatedness of the isolate to strains of R. rickettsii from Central and South America

Developing logistic software platforms: e-market place, a case study

This paper describes a framework for software development with emphasis on logistics platforms. Specifically, a case study is presented regarding the Logport program in Colombia’s Caribbean coast. The software development is based on the merging of modeling, design, and agile development techniques aimed towards software production. The agile methodologies discussed herein include Scrum, XP, and Crystal among others, and specific verification and validation aspects of CMMI 1.3 are evaluated. Furthermore, the integration of emerging technologies including elastic computing in cloud computing that allows scaled integration, security, load balancing, process speed, and high concurrency among other features are discussed. Finally, the proposed solutions cover actual and emergent needs in a B2B or B2C electronic commerce dynamic environment where suppliers and clients offer and demand transport, storage, and customs services. In this environment, their goal is to ensure there is added value to their logistics processes starting at the inputs and all the way to the outputs of the commercial business processes. Colombia’s Caribbean region is one such multimodal and multiport environment in which there is constant demand for low cost, time and storage optimization, and customs reliability for the businesspersons of this region, which serves as a Hub for the American Caribbean

“Publishing Is Mystical”: The Latinx Caucus Bibliography, Top-Tier Journals, and Minority Scholarship

In 2014, members of the NCTE/CCCC Latinx Caucus began contributing citations to a shared Google Document (GDoc) that suggested a relatively significant contribution of scholarship to the field of Rhetoric and Composition studies. Scholars of color have argued that rhetoric and composition scholarship fails to represent diversity in academic publications (Baca; Banks; Jones Royster; Pimentel; Ruíz). This study examines statistical data arrived at through analysis of the NCTE/CCCC Latinx Caucus Bibliography, with survey and interview data from Latinx scholars providing important context about publishing for people of color