Mitochondrial DNA transfer: some reflections from the United Kingdom

Recent medical advances and subsequent law reform in the United Kingdom have reignited debate about the ethics of mitochondrial DNA donation and transfer. The potential personal and societal benefits of permitting such practices must be considered against the ethical issues raised by them. It is argued that each objection is defeasible, assuming that safety and efficacy issues can be resolved. A brief description of the new provisions in the UK is provided

The Predictive Approach to Teaching Statistics.

Statistics is commonly taught as a set of techniques to aid in decision making, by extracting information from data. It is argued here that the underlying purpose, often implicit rather than explicit, of every statistical analysis is to establish a set of probability models which can be used to predict values of one or more variables. Such a model constitutes 'information' only in the sense, and to the extent, that it provides predictions of sufficient quality to be useful for decision making. The quality of the decision making is determined by the quality of the predictions, and hence by that of the models used. Using natural criteria, the 'best predictions' for nominal and numeric variables are respectively the mode and mean. For a nominal variable, the quality of a prediction is measured by the probability of error; for a numeric variable, it is specified using a prediction interval. Presenting statistical analysis in this way provides students with a clearer understanding of what a statistical analysis is, and its role in decision making.Statistics, teaching, prediction, probability model, prediction interval.

The DART-Europe project: towards developing a European theses portal

This paper will report on the new European theses project DART-Europe. The purpose of this project is to align institutional and national e-theses developments across Europe with the wider open archives movement by the construction of a European portal for research theses, thus enabling a global view of European institutional research assets. This project is driven through an innovative partnership between an information provider and an international body of university libraries and open access consortia. The project’s goal is to explore the creation of a European model for the deposit, discovery, use and long-term care of research theses in an open access environment. The paper will outline the projected outcomes of DART-Europe, which is an active group of institutions in addition to a technical service. To this end, DART-Europe is engaged with disciplines and institutions that are widening the definition of research by redefining the formats of theses. For institutions and countries without a repository infrastructure, DART-Europe will enable the creation of a depository. Institutions and countries with a repository infrastructure can engage with DART-Europe to deliver their e-theses. DART-Europe acts as a technology bridge for researchers between those who have existing infrastructures and those who do not. The DART-Europe architecture assumes free at point of use access to full text theses, whether held on the DART-Europe server or by institutional repositories. This paper will provide session attendees with the current progress of this initiative, including a report on the 5 strands of the project, including: architecture; creation of a management tool kit; content acquisition; digital preservation and an investigation of business models

ICI optical data storage tape

Optical data storage tape is now a commercial reality. The world's first successful development of a digital optical tape system is complete. This is based on the Creo 1003 optical tape recorder with ICI 1012 write-once optical tape media. Several other optical tape drive development programs are underway, including one using the IBM 3480 style cartridge at LaserTape Systems. In order to understand the significance and potential of this step change in recording technology, it is useful to review the historical progress of optical storage. This has been slow to encroach on magnetic storage, and has not made any serious dent on the world's mountains of paper and microfilm. Some of the reasons for this are the long time needed for applications developers, systems integrators, and end users to take advantage of the potential storage capacity; access time and data transfer rate have traditionally been too slow for high-performance applications; and optical disk media has been expensive compared with magnetic tape. ICI's strategy in response to these concerns was to concentrate its efforts on flexible optical media; in particular optical tape. The manufacturing achievements, media characteristics, and media lifetime of optical media are discussed

Rest Frame Optical Spectra of Lyman Break Galaxies: Other Lensing Arcs around MS1512-cB58

We have obtained near-infrared spectra of two images of the galaxy at z=2.72 which is gravitationally lensed by the foreground cluster MS1512+36. The brighter arc, cB58, is an image of only the nucleus and the southern half of the background galaxy, while the fainter image, A2, encompasses the entire background galaxy. Thus the gravitational lensing provides spatial resolution on a smaller scale than is routinely available by other methods. Our observations indicate no evidence for any systematic rotational velocity gradient across the face of this galaxy. The nucleus and outer regions of the galaxy do not differ in their gas reddening or excitation level, based on the identical Hα/5007 ratios. cB58 (which is more dominated by the nucleus) has relatively stronger continuum emission, perhaps because of a higher ratio of old to young stars, compared to the outer parts of the galaxy. A second emission line source, denoted as K1, at a slightly lower redshift was serendipitously detected in the slit. It appears to be the gravitationally lensed image of another background galaxy in the same group as cB58

Mayall:a framework for desktop JavaScript auditing and post-exploitation analysis

Writing desktop applications in JavaScript offers developers the opportunity to write cross-platform applications with cutting edge capabilities. However in doing so, they are potentially submitting their code to a number of unsanctioned modifications from malicious actors. Electron is one such JavaScript application framework which facilitates this multi-platform out-the-box paradigm and is based upon the Node.js JavaScript runtime --- an increasingly popular server-side technology. In bringing this technology to the client-side environment, previously unrealized risks are exposed to users due to the powerful system programming interface that Node.js exposes. In a concerted effort to highlight previously unexposed risks in these rapidly expanding frameworks, this paper presents the Mayall Framework, an extensible toolkit aimed at JavaScript security auditing and post-exploitation analysis. The paper also exposes fifteen highly popular Electron applications and demonstrates that two thirds of applications were found to be using known vulnerable elements with high CVSS scores. Moreover, this paper discloses a wide-reaching and overlooked vulnerability within the Electron Framework which is a direct byproduct of shipping the runtime unaltered with each application, allowing malicious actors to modify source code and inject covert malware inside verified and signed applications without restriction. Finally, a number of injection vectors are explored and appropriate remediations are proposed

Close pairs of galaxies with different activity levels

We selected and studied 180 pairs with dV < 800 km/s and Dp < 60 kpc containing Markarian (MRK) galaxies to investigate the dependence of galaxies' integral parameters, star-formation (SF) and active galactic nuclei (AGN) properties on kinematics of pairs, their structure and large-scale environments. Projected radial separation Dp and perturbation level P are better measures of interaction strength than dV. The latter correlates with the density of large-scale environment and with the morphologies of galaxies. Both galaxies in a pair are of the same nature, the only difference is that MRK galaxies are usually righter than their neighbors. Specific star formation rates (SSFR) of galaxies in pairs with smaller Dp or dV is in average 0.5 dex higher than that of galaxies in pairs with larger Dp or dV. Closeness of a neighbor with the same and later morphological type increases the SSFR, while earlier-type neighbors do not increase SSFR. Major interactions/mergers trigger SF and AGN more effectively than minor ones. The fraction of AGNs is higher in more perturbed pairs and pairs with smaller Dp. AGNs typically are in stronger interacting systems than star-forming and passive galaxies. There are correlations of both SSFRs and spectral properties of nuclei between pair members.Comment: 4 pages, 3 figures. arXiv admin note: substantial text overlap with arXiv:1310.024

Sustainable Urban Drainage Systems (SUDS) treatment train assessment tool

This paper outlines a rationale and scoring system for the stormwater treatment train assessment tool (STTAT) which is a proposed regulatory tool for Sustainable Urban Drainage Systems (SUDS). STTAT provides guidance and regulatory consistency for developers about the requirements of planners and the Scottish Environment Protection Agency (SEPA). The tool balances the risks of pollution to the receiving water body with the treatment provided in a treatment train. It encourages developers to take SUDS into account early, avoiding any misunderstanding of SUDS requirements at the planning stage of a development. A pessimistic view on pollution risks has been adopted since there may be a change of land use on the development in the future. A realistic view has also been taken of maintenance issues and the ‘survivability’ of a SUDS component. The development of STTAT as a response to the requirements of the Water Framework Directive is explored, the individual scores being given in tabular format for receiving water and catchment risks. Treatment scores are proposed for single SUDS components as well as multiple components within treatment trains. STTAT has been tested on a range of sites, predominantly in Scotland where both development and receiving water information was known. The operational tool in use by SEPA is presented