Substance abuse in first-episode schizophrenic patients: a retrospective study

Several studies suggest a high comorbidity of substance abuse and schizophrenia, associated with higher frequency of relapse, more positive symptoms and depression, cognitive impairment, poorer outcome and treatment response. A high incidence of substance abuse is also observed in first-episode patients. Among patients with substance abuse, the onset precedes the onset of psychosis of several years in most cases. All the patients with a first episode of schizophrenia, at first admission to the Psychiatric Service of Diagnosis and Treatment of Ospedale Maggiore of Milan during the years 1990 to 2004, have been included in our study. The clinical evaluation has been obtained considering the following items of Brief Psychiatric Rating Scale (BPRS): conceptual disorganization, depressed mood, hostility, hallucinations, unusual content of thought. The results showed that 34.7% of first-episode schizophrenic patients had a lifetime history of substance abuse. The age of onset of schizophrenia is significantly lower for drug abusers than for patients without any type of abuse and for alcohol abusers (p < 0.005). In multi drug abusers, cannabis resulted the most frequently used (49%), followed by alcohol (13%), and cocaine (4%). Substance abusers have obtained a significant higher score in "thought disturbance" item (p < 0.005) and in "hostility" item (p < 0.005) compared to non substance abusers. Non drug abusers showed lower mean scores of "hostility" item compared to cocaine abusers and multi drug abusers (p < 0.005). Our findings seem to indicate that substance abuse in the early course of illness determines an earlier onset of schizophrenia and increases severity of some psychotic symptoms like "hallucination" and "unusual content of thought". Therefore persons incurring a risk of schizophrenia may be warned of the possible relation between substances and psychosis and have to be counselled against the use of them

Exact results in planar N=1 superconformal Yang-Mills theory

In the \beta-deformed N=4 supersymmetric SU(N) Yang-Mills theory we study the class of operators O_J = Tr(\Phi_i^J \Phi_k), i\neq k and compute their exact anomalous dimensions for N,J\to\infty. This leads to a prediction for the masses of the corresponding states in the dual string theory sector. We test the exact formula perturbatively up to two loops. The consistency of the perturbative calculation with the exact result indicates that in the planar limit the one--loop condition g^2=h\bar{h} for superconformal invariance is indeed sufficient to insure the {\em exact} superconformal invariance of the theory. We present a direct proof of this point in perturbation theory. The O_J sector of this theory shares many similarities with the BMN sector of the N=4 theory in the large R--charge limit.Comment: LaTex, 14 pages, 3 figures; v2: minor corrections and one reference adde

CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells

Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear. Here we show, using chimeric mice, cell depletion and adoptive cell transfer, that CD1d–lipid presentation by Bregs induces iNKT cells to secrete interferon (IFN)-γ to contribute, partially, to the downregulation of T helper (Th)1 and Th17-adaptive immune responses and ameliorate experimental arthritis. Mice lacking CD1d-expressing B cells develop exacerbated disease compared to wild-type mice, and fail to respond to treatment with the prototypical iNKT cell agonist α-galactosylceramide. The absence of lipid presentation by B cells alters iNKT cell activation with disruption of metabolism regulation and cytokine responses. Thus, we identify a mechanism by which Bregs restrain excessive inflammation via lipid presentation

Multiple plasmon resonances in naturally-occurring multiwall nanotubes: infrared spectra of chrysotile asbestos

Chrysotile asbestos is formed by densely packed bundles of multiwall hollow nanotubes. Each wall in the nanotubes is a cylindrically wrapped layer of $Mg_3 Si_2 O_5 (OH)_4$. We show by experiment and theory that the infrared spectrum of chrysotile presents multiple plasmon resonances in the Si-O stretching bands. These collective charge excitations are universal features of the nanotubes that are obtained by cylindrically wrapping an anisotropic material. The multiple plasmons can be observed if the width of the resonances is sufficiently small as in chrysotile.Comment: 4 pages, 5 figures. Revtex4 compuscript. Misprint in Eq.(6) correcte

Double–blind control of the data manager doesn't have any impact on data entry reliability and should be considered as an avoidable cost

<p>Abstract</p> <p>Background</p> <p>Database systems have been developed to store data from large medical trials and survey studies. However, a reliable data storage system does not guarantee data entering reliability.</p> <p>We aimed to evaluate if double-blind control of the data manager might have any effect on data-reliability. Our secondary aim was to assess the influence of the inserting position in the insertion-sheet on data-entry accuracy and the effectiveness of electronic controls in identifying data-entering mistakes.</p> <p>Methods</p> <p>A cross-sectional survey and single data-manager data entry.</p> <p>Data from PACMeR_02 survey, which had been conducted within a framework of the SESy-Europe project (PACMeR_01.4), were used as substrate for this study. We analyzed the electronic storage of 6446 medical charts. We structured data insertion in four sequential phases. After each phase, the data stored in the database were tested in order to detect unreliable entries through both computerized and manual random control. Control was provided in a double blind fashion.</p> <p>Results</p> <p>Double-blind control of the data manager didn't improve data entry reliability. Entries near the end of the insertion sheet were correlated with a larger number of mistakes. Data entry monitoring by electronic-control was statistically more effective than hand-searching of randomly selected medical records.</p> <p>Conclusion</p> <p>Double-blind control of the data manager should be considered an avoidable cost. Electronic-control for monitoring of data-entry reliability is suggested.</p

Phonon softening and superconductivity in tellurium under pressure

The phonon dispersion and the electron-phonon interaction for the $\beta$-Po and the bcc high pressure phases of tellurium are computed with density-functional perturbation theory. Our calculations reproduce and explain the experimentally observed pressure dependence of the superconducting critical temperature (T$_{\rm c}$) and confirm the connection between the jump in T$_{\rm c}$ and the structural phase transition. The phonon contribution to the free energy is shown to be responsible for the difference in the structural transition pressure observed in low and room temperature experiments.Comment: Revtex, 4 Postscript figures, to appear in Phys. Rev. Let

Giants On Deformed Backgrounds

We study giant graviton probes in the framework of the three--parameter deformation of the AdS_5 x S^5 background. We examine both the case when the brane expands in the deformed part of the geometry and the case when it blows up into AdS. Performing a detailed analysis of small fluctuations around the giants, the configurations turn out to be stable. Our results hold even for the supersymmetric Lunin-Maldacena deformation.Comment: LaTex, 28 pages, uses JHEP3; v2: minor corrections, references added; v3: final version accepted for publication in JHE

How Can Scientific Literature Support Decision-Making in the Renovation of Historic Buildings? An Evidence-Based Approach for Improving the Performance of Walls

Buildings of heritage significance due to their historical, architectural, or cultural value, here called historic buildings, constitute a large proportion of the building stock in many countries around the world. Improving the performance of such buildings is necessary to lower the carbon emissions of the stock, which generates around 40% of the overall emissions worldwide. In historic buildings, it is estimated that heat loss through external walls contributes significantly to the overall energy consumption, and is associated with poor thermal comfort and indoor air quality. Measures to improve the performance of walls of historic buildings require a balance between energy performance, indoor environmental quality, heritage significance, and technical compatibility. Appropriate wall measures are available, but the correct selection and implementation require an integrated process throughout assessment (planning), design, construction, and use. Despite the available knowledge, decision-makers often have limited access to robust information on tested retrofit measures, hindering the implementation of deep renovation. This paper provides an evidence-based approach on the steps required during assessment, design, and construction, and after retrofitting through a literature review. Moreover, it provides a review of possible measures for wall retrofit within the deep renovation of historic buildings, including their advantages and disadvantages and the required considerations based on context

Rendimento do café conilon em função das formas de processamento e secagem.

A cafeicultura é a atividade agrícola mais importante na agricultura capixaba. A escolha do método de secagem, assim como das técnicas empregadas durante o processamento, é essencial para a obtenção de um rendimento superior, além da produção de um produto de melhor qualidade. O objetivo desse trabalho foi avaliar o rendimento final do café conilon submetido a diferentes métodos de processamento e secagem. O estudo foi realizado na Fazenda Experimental de Marilândia (Incaper). O delineamento experimental utilizado foi de blocos inteiramente casualizados com quatro tratamentos e oito repetições. Os tratamentos estudados foram: café colhido e levado diretamente da roça para secador rotativo, café colhido e levado diretamente da roça para terreiro de cimento, café colhido, lavado e seco em terreiro de cimento e café colhido, descascado e seco em terreiro de cimento. Dentre as metodologias avaliadas, os maiores rendimentos finais podem ser obtidos com o processamento do café conilon utilizando a via úmida com secagem em terreiro de cimento, para as condições estudadas. Não foi encontrada diferenças significativas entre a secagem feita em secador rotativo e em terreiro de cimento

Variability of Arundo donax growth in dry-farming as a function of soil properties

Arundo donax L., commonly known as giant reed or arundo, is a perennial rhizomatous grass that has been studied since the decade of 1980 for bioenergy. In the Mediterranean region -characterised by dry and hot summers- arundo is usually grown with the support of irrigation. However, there is evidence that this plant species can tolerate dry-farming conditions once the crop is fully established. In this work the variation observed in plant growth of a 5-year-old arundo crop when the management changed from irrigated to dry-farming, is assessed. The hypothesis underlying this work was that punctual variations of soil properties might be responsible for the differences observed in plant growt