Volcanic hazard assessment at the Campi Flegrei caldera

Previous and new results from probabilistic approaches based on available volcanological data from real eruptions of Campi Flegrei, are assembled in a comprehensive assessment of volcanic hazards at the Campi Flegrei caldera, in order to compare the volcanic hazards related to the different types of events. Hazard maps based on a very wide set of numerical simulations, produced using field and laboratory data as input parameters relative to the whole range of fallout and pyroclastic-flow events and their relative occurrence, are presented. The results allow us to quantitatively evaluate and compare the hazard related to pyroclastic fallout and density currents (PDCs) in the Campi Flegrei area and its surroundings, including the city of Naples. Due to the dominant wind directions, the hazard from fallout mostly affects the area east of the caldera, and the caldera itself, with the level of probability and expected thickness decreasing with distance from the caldera and outside the eastern sectors. The hazard from PDCs decrease roughly radially with distance from the caldera centre and is strongly controlled by the topographic relief, which produces an effective barrier to propagation of PDCs to the east and northeast, areas which include metropolitan Naples. The main result is that the metropolitan area of Naples would be directly exposed to both fallout and PDCs. Moreover, the level of probability for critical tephra accumulation by fallout is relatively high, even for moderate-scale events, while, due to the presence of topographic barriers, the hazard from PDCs is only moderate and mostly associated with the largest events

Activation studies of the β-carbonic anhydrases from Escherichia coli with amino acids and amines

A β-carbonic anhydrase (CA, EC 4.2.1.1) from the widespread bacterium Escherichia coli (EcoCAβ), encoded by the CynT2 gene, has been investigated for its catalytic properties and enzymatic activation by a panel of amino acids and amines. EcoCAβ showed a significant catalytic activity for the hydration of CO2 to bicarbonate and a proton, with a kinetic constant kcat of 5.3 × 105 s− and a Michaelis–Menten constant KM of 12.9 mM. The most effective EcoCAβ activators were L- and D-DOPA, L-Tyr, 4-amino-Phe, serotonin and L-adrenaline, with KAs from 2.76 to 10.7 µM. L-His, 2-pyridyl-methylamine, L-Asn and L-Gln were relatively weak activators (KAs from 36.0 to 49.5 µM). D-His, L- and D-Phe, L- and D-Trp, D-Tyr, histamine, dopamine, 2-(aminoethyl)pyridine/piperazine/morpholine, L-Asp, L- and D-Glu have KAs from 11.3 to 23.7 µM. Endogenous CA activators may play a role in bacterial virulence and colonisation of the host

Lethal Thermal Impact at Periphery of Pyroclastic Surges: Evidences at Pompeii

Background: The evaluation of mortality of pyroclastic surges and flows (PDCs) produced by explosive eruptions is a major goal in risk assessment and mitigation, particularly in distal reaches of flows that are often heavily urbanized. Pompeii and the nearby archaeological sites preserve the most complete set of evidence of the 79 AD catastrophic eruption recording its effects on structures and people. Methodology/Principal Findings: Here we investigate the causes of mortality in PDCs at Pompeii and surroundings on the bases of a multidisciplinary volcanological and bio-anthropological study. Field and laboratory study of the eruption products and victims merged with numerical simulations and experiments indicate that heat was the main cause of death of people, heretofore supposed to have died by ash suffocation. Our results show that exposure to at least 250uC hot surges at a distance of 10 kilometres from the vent was sufficient to cause instant death, even if people were sheltered within buildings. Despite the fact that impact force and exposure time to dusty gas declined toward PDCs periphery up to the survival conditions, lethal temperatures were maintained up to the PDCs extreme depositional limits. Conclusions/Significance: This evidence indicates that the risk in flow marginal zones could be underestimated by simply assuming that very thin distal deposits, resulting from PDCs with poor total particle load, correspond to negligible effects. Therefore our findings are essential for hazard plans development and for actions aimed to risk mitigation at Vesuvius an

Run 2 Upgrades to the CMS Level-1 Calorimeter Trigger

The CMS Level-1 calorimeter trigger is being upgraded in two stages to maintain performance as the LHC increases pile-up and instantaneous luminosity in its second run. In the first stage, improved algorithms including event-by-event pile-up corrections are used. New algorithms for heavy ion running have also been developed. In the second stage, higher granularity inputs and a time-multiplexed approach allow for improved position and energy resolution. Data processing in both stages of the upgrade is performed with new, Xilinx Virtex-7 based AMC cards.Comment: 10 pages, 7 figure

Triggering on electrons, jets and tau leptons with the CMS upgraded calorimeter trigger for the LHC RUN II

The Compact Muon Solenoid (CMS) experiment has implemented a sophisticated two-level online selection system that achieves a rejection factor of nearly 10e5. During Run II, the LHC will increase its centre-of-mass energy up to 13 TeV and progressively reach an instantaneous luminosity of 2e34cm-2s-1. In order to guarantee a successful and ambitious physics programme under this intense environment, the CMS Trigger and Data acquisition (DAQ) system has been upgraded. A novel concept for the L1 calorimeter trigger is introduced the Time Multiplexed Trigger (TMT). In this design, nine main receive each all of the calorimeter data from an entire event provided by 18 preprocessors. This design is not different from that of the CMS DAQ and HLT systems. The advantage of the TMT architecture is that a global view and full granularity of the calorimeters can be exploited by sophisticated algortihms. The goal is to maintain the current thresholds for calorimeter objects and improve the performance for their selection. The performance of these algorithms will be demonstrated, both in terms of efficiency and rate reduction. The callenging aspects of the pile-up mitigation and firmware design will be presented