1,448 research outputs found
10411 Abstracts Collection -- Computational Video
From 10.10.2010 to 15.10.2010, the Dagstuhl Seminar 10411 ``Computational Video \u27\u27 was held in Schloss Dagstuhl~--~Leibniz Center for Informatics.
During the seminar, several participants presented their current
research, and ongoing work and open problems were discussed. Abstracts of
the presentations given during the seminar as well as abstracts of
seminar results and ideas are put together in this paper. The first section
describes the seminar topics and goals in general.
Links to extended abstracts or full papers are provided, if available
Multiplierz: An Extensible API Based Desktop Environment for Proteomics Data Analysis
BACKGROUND. Efficient analysis of results from mass spectrometry-based proteomics experiments requires access to disparate data types, including native mass spectrometry files, output from algorithms that assign peptide sequence to MS/MS spectra, and annotation for proteins and pathways from various database sources. Moreover, proteomics technologies and experimental methods are not yet standardized; hence a high degree of flexibility is necessary for efficient support of high- and low-throughput data analytic tasks. Development of a desktop environment that is sufficiently robust for deployment in data analytic pipelines, and simultaneously supports customization for programmers and non-programmers alike, has proven to be a significant challenge. RESULTS. We describe multiplierz, a flexible and open-source desktop environment for comprehensive proteomics data analysis. We use this framework to expose a prototype version of our recently proposed common API (mzAPI) designed for direct access to proprietary mass spectrometry files. In addition to routine data analytic tasks, multiplierz supports generation of information rich, portable spreadsheet-based reports. Moreover, multiplierz is designed around a "zero infrastructure" philosophy, meaning that it can be deployed by end users with little or no system administration support. Finally, access to multiplierz functionality is provided via high-level Python scripts, resulting in a fully extensible data analytic environment for rapid development of custom algorithms and deployment of high-throughput data pipelines. CONCLUSION. Collectively, mzAPI and multiplierz facilitate a wide range of data analysis tasks, spanning technology development to biological annotation, for mass spectrometry-based proteomics research.Dana-Farber Cancer Institute; National Human Genome Research Institute (P50HG004233); National Science Foundation Integrative Graduate Education and Research Traineeship grant (DGE-0654108
Socioeconomic Inequalities in Mortality Rates in Old Age in the World Health Organization Europe Region
Socioeconomic adversity is among the foremost fundamental causes of human suffering, and this is no less true in old age. Recent reports on socioeconomic inequalities in mortality rate in old age suggest that a low socioeconomic position continues to increase the risk of death even among the oldest old. We aimed to examine the evidence for socioeconomic mortality rate inequalities in old age, including information about associations with various indicators of socioeconomic position and for various geographic locations within the World Health Organization Region for Europe. The articles included in this review leave no doubt that inequalities in mortality rate by socioeconomic position persist into the oldest ages for both men and women in all countries for which information is available, although the relative risk measures observed were rarely higher than 2.00. Still, the available evidence base is heavily biased geographically, inasmuch as it is based largely on national studies from Nordic and Western European countries and local studies from urban areas in Southern Europe. This bias will hamper the design of European-wide policies to reduce inequalities in mortality rate. We call for a continuous update of the empiric evidence on socioeconomic inequalities in mortality rate
Multiclass Semi-Supervised Learning on Graphs using Ginzburg-Landau Functional Minimization
We present a graph-based variational algorithm for classification of
high-dimensional data, generalizing the binary diffuse interface model to the
case of multiple classes. Motivated by total variation techniques, the method
involves minimizing an energy functional made up of three terms. The first two
terms promote a stepwise continuous classification function with sharp
transitions between classes, while preserving symmetry among the class labels.
The third term is a data fidelity term, allowing us to incorporate prior
information into the model in a semi-supervised framework. The performance of
the algorithm on synthetic data, as well as on the COIL and MNIST benchmark
datasets, is competitive with state-of-the-art graph-based multiclass
segmentation methods.Comment: 16 pages, to appear in Springer's Lecture Notes in Computer Science
volume "Pattern Recognition Applications and Methods 2013", part of series on
Advances in Intelligent and Soft Computin
- ā¦