Games in Tholkappiyam and Aganaanooru

Tamil culture places a high value on grammar and literature. A sport thought of as a hobby  that  focuses on the civilization and culture of every people. From the sangam era to the present, the contribution of games has dominted grammar and literature. The greatest treasure that can never be destroyed is the world of games. Humans benefit greatly from sport in terms of agility and fun. The best medicine for the human body and for life is sports. Additionally, it is clamied to rejuvenate peoples life. They provide the body with the necessary energy, health, and sense of community. The game improves navigation and speaking skills for both kids and adults. As a result, every ones capacity for rational, in-depth thought improves.The lyrics allusions to the games played in Tholkappiaym and Aganaanooru are dispersed through Sout and arranged harmoniously. Tamil community values sport as a significant aspect

IMPROVED EVOLUTIONARY SUPPORT VECTOR MACHINE CLASSIFIER FOR CORONARY ARTERY HEART DISEASE PREDICTION AMONG DIABETIC PATIENTS

Soft computing paves way many applications including medical informatics. Decision support system has gained a major attention that will aid medical practitioners to diagnose diseases. Diabetes mellitus is hereditary disease that might result in major heart disease. This research work aims to propose a soft computing mechanism named Improved Evolutionary Support Vector Machine classifier for CAHD risk prediction among diabetes patients. The attribute selection mechanism is attempted to build with the classifier in order to reduce the misclassification error rate of the conventional support vector machine classifier. Radial basis kernel function is employed in IESVM. IESVM classifier is evaluated through the performance metrics namely sensitivity, specificity, prediction accuracy and Matthews correlation coefficient (MCC) and also compared with existing work and our earlier proposed works

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND GLIPIZIDE

A novel, precise and accurate stability indicating RP-HPLC method was developed and validated for the simultaneous estimation of Metformin and Glipizide in combined pharmaceutical dosage form. Chromatographic separation was achieved on Microsorb-MV C18 column (250 × 4.6 mm, 5 μm) with UV detection at 257 nm. The mobile phase consists of acetate buffer (pH 4.0) and acetonitrile in the ratio of 60:40 v/v and at a flow rate of 1.0 mL/min. The method was linear over the concentration range of 60-140 μg/mL for Metformin and 10-50 μg/mL for Glipizide. The retention times for Metformin and Glipizide were found to be 2.434 min and 5.710 min respectively. The mean percentage recoveries of Metformin and Glipizide were found to be 100.42% and 100.39% respectively. The method was validated and was successfully employed for the routine quantitative analysis of pharmaceutical formulations containing Metformin and Glipizide in combined pharmaceutical formulation

Identification of a putative transcription factor in Candida albicans that can complement the mating defect of Saccharomyces cerevisiae ste12 mutants

We have isolated an acid proteinase-related gene, ACPR, from Candida albicans using a partial clone (Ganesan, K., Banerjee, A., and Datta, A. (1991) Infect. Immun. 59, 2972-2977) as a probe. Sequencing of the full-length gene revealed an open reading frame that can encode a protein of 699 amino acids. The deduced NH2-terminal amino acid sequence did not correspond with that determined from the purified secretory acid proteinase; however, the encoded protein is antigenically related to secretory acid proteinase and has a putative active site for acid proteinase. Interestingly, the amino acid sequence of the NH2-terminal 215 residues of Acprp is highly similar to the DNA binding domain of Ste12p of Saccharomyces cerevisiae. Gel retardation experiments showed that this region of Acprp, like Ste12p, could bind to S. cerevisiae pheromone response elements, suggesting that Acprp has a function similar to Ste12p. Chimeric constructs composed of S. cerevisiae STE12 and C. albicans ACPR genes complemented the mating defect of S. cerevisiae a or alpha ste12 mutants. Our results suggest the presence of a signal transduction system in C. albicans similar to that of S. cerevisiae mating pathway

Effectiveness of therapeutic play on the level of anxiety among hospitalized children between 3-6 years

Today’s children are tomorrow’s citizen, so the health of the children is very important in determining the prosperity of a country. Indian journal of pediatrics (2005) indicated that 20% of children have some form of psychological problem and that of 70% of these are helped through the use of psychological based therapies such as play and creative arts. According to Jean Piaget, knowledge arises neither from objects nor the child, but from interactions between the child and those objects. Therapeutic play is one type of play therapy. Constructive play helps to relieve anxiety of the child. Play is essential for a child to be healthy as well as to grow healthy. A study was conducted to assess the effectiveness of therapeutic play on the level of anxiety among hospitalized children between 3- 6 years in Stanley Hospital,Chennai. The objective of the study was to determine the effectiveness of therapeutic play on the level of anxiety among hospitalized children between 3-6 years. The study was conducted by adopting a one group pre test post test research design. The sample size was sixty children between 3-6 years who fulfilled the inclusive criteria and they were selected by convenient sampling technique. During pre test the required data were collected by using the observation checklist. Therapeutic play was given to the child for 2 hours on each day for 3 days. After the intervention completes post test was conducted by using the same observation checklist. The analysis revealed that there was marked decrease in the mean value from 43.93 in the pre test level to 31.86 in the post test level of anxiety. The standard deviation is increased from 7.57 in pre test to 17.71 in post test. The‘t’ value at 18.47 is highly significant at p<0.001 level. So there was significant decrease in the post test level of anxiety among hospitalized children between 3-6 yrs. Therefore therapeutic play can be used as a safe and effective tool, which helps in reducing anxiety

Influence of Torrefaction on Lignocellulosic Woody Biomass of Nigerian Origin

Torrefaction process is a thermal treatment that can improve quality of lignocellulosic biomass into a carbon-rich and hydrophobic feedstock which is applicable as fuel and metallurgical reductant. Biomass (Melina and Teak wood) of Nigerian origin was subjected to mild (240o C) and severe (300o C) torrefaction treatment at different residence times (30 and 60 min) and particle sizes (+0.5 - 2 mm and +4 - 6.35 mm). Raw biomass and biochar from torrefaction were subjected to proximate, ultimate, higher heating value and SEM analyses. The mass yield obtained for mild treatment conditions for both biomass was in the range of 72 - 84 (wt. %) compared to 40 - 54 (wt. %) under severe treatment conditions. However, 33 - 56 % increment in higher hating value was observed for severe treatment conditions as against 11 - 17 % of mild treatment condition. This ultimately led to a 60 - 72 (wt. %) energy yield for severe treatment conditions and 73 - 94 (wt. %). The fixed carbon content increased from the range of 8 - 11 (wt. %) to 20 - 61 (wt. %) after torrefaction. The volatile matter content under mild condition was reduced by 7 - 10 % for both biomass as against 41 - 47 % under severe treatment condition. The fuel ratio increased from 0.11 and 0.15 for Melina and Teak woods respectively to a range of 0.22 - 0.25 for mild treatment conditions and 0.97 - 1.75 for severe treatment condition. The H/C and O/C atomic ratios of biochar were lowered towards that of sub-bituminous coal and peat. A honey-comb-like structure with cylindrical holes were observed for biochar compared to the fibrous and spongy nature of the raw biomass. Biomass of Nigerian origin were improved under torrefaction and thus can be suitable as feedstock in thermal or metallurgical applications