A Sharing- and Competition-Aware Framework for Cellular Network Evolution Planning

Mobile network operators are facing the difficult task of significantly increasing capacity to meet projected demand while keeping CAPEX and OPEX down. We argue that infrastructure sharing is a key consideration in operators' planning of the evolution of their networks, and that such planning can be viewed as a stage in the cognitive cycle. In this paper, we present a framework to model this planning process while taking into account both the ability to share resources and the constraints imposed by competition regulation (the latter quantified using the Herfindahl index). Using real-world demand and deployment data, we find that the ability to share infrastructure essentially moves capacity from rural, sparsely populated areas (where some of the current infrastructure can be decommissioned) to urban ones (where most of the next-generation base stations would be deployed), with significant increases in resource efficiency. Tight competition regulation somewhat limits the ability to share but does not entirely jeopardize those gains, while having the secondary effect of encouraging the wider deployment of next-generation technologies

In Vitro Modeling of Mechanics in Cancer Metastasis

In addition to a multitude of genetic and biochemical alterations, abnormal morphological, structural, and mechanical changes in cells and their extracellular environment are key features of tumor invasion and metastasis. Furthermore, it is now evident that mechanical cues alongside biochemical signals contribute to critical steps of cancer initiation, progression, and spread. Despite its importance, it is very challenging to study mechanics of different steps of metastasis in the clinic or even in animal models. While considerable progress has been made in developing advanced in vitro models for studying genetic and biological aspects of cancer, less attention has been paid to models that can capture both biological and mechanical factors realistically. This is mainly due to lack of appropriate models and measurement tools. After introducing the central role of mechanics in cancer metastasis, we provide an outlook on the emergence of novel in vitro assays and their combination with advanced measurement technologies to probe and recapitulate mechanics in conditions more relevant to the metastatic disease

Sensitivity analysis of permeability parameters of bovine nucleus pulposus obtained through inverse fitting of the nonlinear biphasic equation : effect of sampling strategy

Permeability controls the fluid flow into and out of soft tissue, and plays an important role in maintaining the health status of such tissue. Accurate determination of the parameters that define permeability is important for the interpretation of models that incorporate such processes. This paper describes the determination of strain-dependent permeability parameters from the nonlinear biphasic equation from experimental data of different sampling frequencies using the Nelder–Mead simplex method. The ability of this method to determine the global optimum was assessed by constructing the whole manifold arising from possible parameter combinations. Many parameter combinations yielded similar fits with the Nelder–Mead algorithm able to identify the global maximum within the resolution of the manifold. Furthermore, the sampling strategy affected the optimum values of the permeability parameters. Therefore, permeability parameter estimations arising from inverse methods should be utilised with the knowledge that they come with large confidence intervals

Active learning-based classification in automated connected vehicles

Machine learning has emerged as a promising paradigm for enabling connected, automated vehicles to autonomously cruise the streets and react to unexpected situations. A key challenge, however, is to collect and select real-time and reliable information for the correct classification of unexpected, and often uncommon, events that may happen on the road. Indeed, the data generated by vehicles, or received from neighboring vehicles, may be affected by errors or have different levels of resolution and freshness. To tackle this challenge, we propose an active learning framework that, leveraging the information collected through onboard sensors as well as received from other vehicles, effectively deals with scarce and noisy data. In particular, given the available information, our solution selects the data to add to the training set by trading off between two essential features: quality and diversity. The results, obtained using realworld data sets, show that our method significantly outperforms state-of-the-art solutions, providing high classification accuracy at the cost of a limited bandwidth requirement for the data exchange between vehicles