Magnetic Field Effects on the Transport Properties of One-sided Rough Wires

We present a detailed numerical analysis of the effect of a magnetic field on the transport properties of a `small-$N$' one-sided surface disordered wire. When time reversal symmetry is broken due to a magnetic field $B$, we find a strong increase with $B$ not only of the localization length $\xi$ but also of the mean free path $\ell$ caused by boundary states. Despite this, the universal relationship between $\ell$ and $\xi$ does hold. We also analyze the conductance distribution at the metal-insulator crossover, finding a very good agreement with Random Matrix Theory with two fluctuating channels within the Circular Orthogonal(Unitary) Ensemble in absence(presence) of $B$Comment: 5 pages, 4 figures, to appear in Phys. Rev.

Microinclusions in cassiterite of different deposits in western Spain

[Resumen] Se incluyen en este estudio casiteritas procedentes de distintos yacimientos de Salamanca y Extremadura que se han seleccionado en función de sus diferentes caracteres: hábito, color, zonaci6n, tipología genética y composición química. Se presenta la descripción microscópica así como la composición química obtenida mediante microsonda de las casiteritas y sus microinclusiones. Cabe destacar una clara relación entre la razón Nb/Ta y el tipo genético. Por otro lado, la razón Fe/Mn es característica propia del ambiente geoquímico de cada yacimiento. Las casiteritas ricas en Nb y Ta contienen microinclusiones de columbo-tantalita, las casiteritas ricas en Ti y Nb, ilmeno-rutilo y columbo-tantalita y las esencialmente, titaníferas , rutilos.[Abstract] Cassiterites of different deposits in western Spain were selectioned for this study by different characteristics: colour, crystal habit, zonation, genetic type and chemical composition. Microscopic description and Microprobe analysis of cassiterites and microinclusions are presented. There is correlation between columbite-tantalite composition (Nb/Ta) and the genetic type; on the other hand, Fe/Mn depends of geochemical enviroment in ore deposits formation. The Nb-Ta cassiterites contain microinclusions of columbite-tantalite, the Ti-Nb cassiterites microinclusions of ilmeno-rutile and columbite-Tantalite and the Ti-cassiterites, rutiles

Caveolin-1 Modulates Mechanotransduction Responses to Substrate Stiffness through Actin-Dependent Control of YAP

The transcriptional regulator YAP orchestrates many cellular functions, including tissue homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to YAP activity, but the mechanisms controlling this regulation remain largely uncharacterized. We show that CAV1 positively modulates the YAP mechanoresponse to substrate stiffness through actin-cytoskeleton-dependent and Hippo-kinase-independent mechanisms. RHO activity is necessary, but not sufficient, for CAV1-dependent mechanoregulation of YAP activity. Systematic quantitative interactomic studies and image-based small interfering RNA (siRNA) screens provide evidence that this actin-dependent regulation is determined by YAP interaction with the 14-3-3 protein YWHAH. Constitutive YAP activation rescued phenotypes associated with CAV1 loss, including defective extracellular matrix (ECM) remodeling. CAV1-mediated control of YAP activity was validated in vivo in a model of pancreatitis-driven acinar-to-ductal metaplasia. We propose that this CAV1-YAP mechanotransduction system controls a significant share of cell programs linked to these two pivotal regulators, with potentially broad physiological and pathological implications. Moreno-Vicente et al. report that CAV1, a key component of PM mechanosensing caveolae, mediates adaptation to ECM rigidity by modulating YAP activity through the control of actin dynamics and phosphorylation-dependent interaction of YAP with the 14-3-3-domain protein YWHAH. Cav1-dependent YAP regulation drives two pathophysiological processes: ECM remodeling and pancreatic ADM. © 2018 The Author

Anderson localization in a periodic photonic lattice with a disordered boundary

We investigate experimentally the light evolution inside a two-dimensional finite periodic array of weakly- coupled optical waveguides with a disordered boundary. For a completely localized initial condition away from the surface, we find that the disordered boundary induces an asymptotic localization in the bulk, centered around the initial position of the input beam.Comment: 3 pages, 4 figure

Artrosis vertebral en la población de La Encantada (Granátula de Calatrava, Ciudad Real, II milenio a. C.)

X Congreso Nacional de Paleopatología. Univesidad Autónoma de Madrid, septiembre de 200