Tank construction for space vehicles Patent

Liquid propellant tank design with semitoroidal bulkhea

Disability Legislation: An Empirical Analysis of Employer Cost

As U.S. civil rights legislation, Title I of the Americans with Disabilities Act of 1990 (ADA) was created to eliminate workplace discrimination on the basis of disability. Using the United States as an example, this research analyzes the potential for disability legislation to laden employers with excessive cost burdens, specifically expenses from additional workplace injuries and illnesses. In addition, this study looks at the likelihood that employers compensate for these costs by cutting workplace sick leave benefits. Prior to the ADA’s implementation, U.S. employers had the fear of incurring excessive cost. The paper successfully counters this fear by looking first at whether the legislation spawned significant increases in the incident rates of occupational injuries and illnesses, and second, whether employers compensated for soaring compliance costs by decreasing paid sick leave benefits

Effect of various characteristics of raw wood on energy saturation of the chipper

Grinding of raw wood into chips is a complex process depending on various factors. Study of a grinding process is complicated not only because of a large number of these factors, but also because of the possibility of many combinations. Cutting power can be considered to be one of the criterion determining the extent and nature of these factors influence on the grinding process

Primed for Interactions: Investigating the Primed Substrate Channel of the Proteasome for Improved Molecular Engagement

Protein homeostasis is a tightly conserved process that is regulated through the ubiquitin proteasome system (UPS) in a ubiquitin-independent or ubiquitin-dependent manner. Over the past two decades, the proteasome has become an excellent therapeutic target through inhibition of the catalytic core particle, inhibition of subunits responsible for recognizing and binding ubiquitinated proteins, and more recently, through targeted protein degradation using proteolysis targeting chimeras (PROTACs). The majority of the developed inhibitors of the proteasome's core particle rely on gaining selectivity through binding interactions within the unprimed substrate channel. Although this has allowed for selective inhibitors and chemical probes to be generated for the different proteasome isoforms, much remains unknown about the interactions that could be harnessed within the primed substrate channel to increase potency or selectivity. Herein, we discuss small molecules that interact with the primed substrate pocket and how their differences may give rise to altered activity. Taking advantage of additional interactions with the primed substrate pocket of the proteasome could allow for the generation of improved chemical tools for perturbing or monitoring proteasome activity

Demands and Devotion: Cultural Meanings of Work and Overload Among Women Researchers and Professionals in Science and Technology Industries

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136323/1/socf12315_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136323/2/socf12315.pd

Claytonia virginica L.

https://thekeep.eiu.edu/herbarium_specimens_byname/5143/thumbnail.jp

Caged aminoluciferin probe for bioluminescent immunoproteasome activity analysis

The immunoproteasome (iCP) can be expressed under inflammatory conditions, such as exposure to interferon-gamma (IFN-γ), that alerts the cell to begin generating iCP preferentially over the standard proteasome (sCP). With the iCP becoming a widely targeted isoform in a variety of diseases, there is a need to understand its activity and expression in cells and in vivo. Activity-based probes for the iCP have been developed but their application has been limited due to their difficult synthesis and cannot be used in tissues or whole animals. Our lab has previously demonstrated we can monitor iCP activity using a 4-mer peptide linked to a fluorophore and a peptoid. This was utilized in the development of the first cell-permeable iCP activity-based probe that did not include a covalent reactive moiety. Here, we demonstrate that this same peptide recognition sequence can be appended to aminoluciferin, caging it, until its interaction with the iCP. This probe should be applicable to monitor iCP activity in animal models where tumor or other tissue has been engineered to produce luciferase. We anticipate it could also be applied to observe iCP activity as tumors are formed in vivo

More than range exposure: global otters’ vulnerability to climate change

Climate change impact on species is commonly assessed by predicting species’ range change, a measure of a species’ extrinsic exposure. However, this is only one dimension of species’ vulnerability to climate change. Spatial arrangement of suitable habitats (e.g., fragmentation), their degree of protection or human disturbance, as well as species’ intrinsic sensitivity, such as climatic tolerances, are often neglected. Here, we consider components of species’ intrinsic sensitivity to climate change (climatic niche specialization and marginality) together with components of extrinsic exposure (changes in range extent, fragmentation, coverage of protected areas, and human footprint) to develop an integrated vulnerability index to climate change for world’s freshwater otters. As top freshwater predators, otters are among the most vulnerable mammals, with most species being threatened by habitat loss and degradation. All dimensions of climate change exposure were based on present and future predictions of species distributions. Annual mean temperature, mean diurnal temperature range, mean temperature of the wettest quarter, precipitation during the wettest quarter, and precipitation seasonality prove the most important variables for otters. All species are vulnerable to climate change, with global vulnerability index ranging from -0,19 for Lontra longicaudis to -36,9 for Aonyx congicus. However, we found that, for a given species, climate change can have both positive and negative effects on different components of extrinsic exposure, and that measures of species’ sensitivity are not necessarily congruent with measures of exposure. For instance, the range of all African species would be negatively affected by climate change, but their different sensitivity offers a more (Hydrictis maculicollis, Aonyx capensis) or less (Aonyx congicus) pessimistic perspective on their ability to cope with climate change. Also, highly sensitive species like the South-American Pteronura brasiliensis, Lontra provocax, and Lutra perspicillata might face no exposure to climate change. For the Asian Lutra sumatrana, climate change would instead lead to an increased, less fragmented, and more protected range extent, but the range extent would also be shifted into areas with higher human disturbances. Our study represents a balanced example of how to develop an index aimed at comparatively evaluating vulnerability to climate change of different species by combining different aspects of sensitivity and exposure, providing additional information on which to base more efficient conservation strategies