Rückschau auf die traumatologische Kasuistik der abteilung für maxillofaziale Chirurgie des allgemeinen Krankenhauses in Osijek, von seiner gründung am 1. VIII 1968. Bis heute.

Porast povreda u maksilofacijalnoj regiji uopće, kao i sve češća pojava teških povreda ovoga područja, mogu se notirati i u našoj kazuistici. Kao što se to iz statistike vidi, tijekom naše dosadašnje djelatnosti, tj. u roku od posljednjih 15 mjeseci, bilo je 411 povreda, od čega 273 samo mekih tkiva lica, a 138 fraktura i to 128 zatvorenih i 10 otvorenih. Kod maksilofacijalnih povreda kombiniranih s povredama na drugim lokalizacijama tijela, vršene su konzultacije sa odnosnim specijalistima i prema potrebi se primjenjivala timska obrada, a tretiranje se obavljalo prema redu hitnosti. Vanjske rane, rane u usnoj šupljini, kao i raznovrsni prijelomi kosti facijalnog dijela glave tretirani su u zato određenom roku i po principu i tehnici opisanima u suvremenoj literaturi. Rane mekih tkiva dobro su zarašćivale, a kod svih dosad dovršenih tretmana frakture kosti lica došlo je u određenom roku i do konsolidacije i naknadne zadovoljavajuće funkcije odnosnih organa, osim u dva slučaja teških povreda vatrenim oružjem, s kontinuitetnim defektom kosti mandibule, koji su još u tretiranju. U četiri su slučaja bili potrebni rekonstruktivni operativni zahvati, koji su već dijelom u toku, a kod svih povreda izvršena je, poslije skidanja imobilizacijskih naprava, prema potrebi, kompletna sanacija zuba, s punom definitivnom protetskom nadoknadom.The general upward trend in injuries of the maxillofacia region in general, and the steadily growing number of serious injuries of this region has been noted in our casuistics too. Statistics show that in the course of our activity in this newly established Department, i.e. within the last 15 months 411 injuries were registered. Of these 273 were of the soft tissue of the face alone and 138 were fractures. Hundred and twenty-eight fractures were of the closed type and 10 were compound fractures. In maxillofacial injuries combined with injuries of other sites in the body consultations were undertaken with the responsible specialists and where necessary team-work was applied. Treatment was carried out according to the order of urgency. External wounds, wounds in the oral cavity and various fractures of the bones of the facial part of the head were therefore treated urgently and following the principles and technique described in contemporary literature. The wounds of the soft tissue healed well and in all so far treated fractures of the facial bones consolidation occurred within the normal period. Subsequent satisfactory functions of the organs concerned was also achieved with the exception of two cases of very serious injuries inflicted by fire arms with continuous defect of the mandibullar bone. These patients are undergoing special treatment. In four cases reconstructive operative interventions were necessary. These patients are partly undergoing treatment. After removal of the immobilization devices in all of these injuries complete repair of the teeth was undertaken with full definitive prosthetic replacement.Die Zunahme von Verletzungen in der maxillofazialen Region und die immer grössere Zahl von Schwerverletzten dieses Gebietes, geht auch aus unserer Kasuistik hervor. Im Laufe unserer Tätigkeit hatten wir 411 Verletzungen, darunter 273 nur der Gesichts-Weich-teile und 138 Kieferbrüche, wovon 128 geschlossene und 10 offene.Falls diese Verletzungen mit Traumen anderer Körperteile verbunden waren, wurden entsprechende Fachärzte zu Rate gezogen, und nach Bedarf die Behandlung als Teamerbeit durchgeführt. Äussere Wunden, Wunden in der Mundhöhle, als auch verschiedene Knochenbrüche des fazialen Gebietes, wurden nach den herschenden Prinzipien und Technik behandelt. Weichteilwunden heilten gut aus; sämtliche Kieferbrüche sind in der vorgesehenen Frist ausgeheilt, so dass die Funktion zufriedenstellend war. In vier Fällen waren wiederherstellende operative Eingriffe notwendig. Bei allen wurde, nach der Abnahme der Schienen, je nach Bedarf, die prothetische Versorgung durchgeführt

Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

Funding Information: This work was supported by the National Institute of Mental Health / U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium ), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience . Statistical analyses were carried out on the LISA/Genetic Cluster Computer ( https://userinfo.surfsara.nl/systems/lisa ) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind. Funding Information: MBS has in the past 3 years received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech and has stock options in Oxeia Biopharmaceuticals and Epivario. In the past 3 years, NPD has held a part-time paid position at Cohen Veterans Bioscience, has been a consultant for Sunovion Pharmaceuticals, and is on the scientific advisory board for Sentio Solutions for unrelated work. In the past 3 years, KJRe has been a consultant for Datastat, Inc., RallyPoint Networks, Inc., Sage Pharmaceuticals, and Takeda. JLM-K has received funding and a speaking fee from COMPASS Pathways. MU has been a consultant for System Analytic. HRK is a member of the Dicerna scientific advisory board and a member of the American Society of Clinical Psychopharmacology Alcohol Clinical Trials Initiative, which during the past 3 years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Dicerna, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. HRK and JG are named as inventors on Patent Cooperative Treaty patent application number 15/878,640, entitled “Genotype-guided dosing of opioid agonists,” filed January 24, 2018. RP and JG are paid for their editorial work on the journal Complex Psychiatry. OAA is a consultant to HealthLytix. All other authors report no biomedical financial interests or potential conflicts of interest. Funding Information: This work was supported by the National Institute of Mental Health/ U.S. Army Medical Research and Development Command (Grant No. R01MH106595 [to CMN, IL, MBS, KJRe, and KCK], National Institutes of Health (Grant No. 5U01MH109539 to the Psychiatric Genomics Consortium), and Brain & Behavior Research Foundation (Young Investigator Grant [to KWC]). Genotyping of samples was provided in part through the Stanley Center for Psychiatric Genetics at the Broad Institute supported by Cohen Veterans Bioscience. Statistical analyses were carried out on the LISA/Genetic Cluster Computer (https://userinfo.surfsara.nl/systems/lisa) hosted by SURFsara. This research has been conducted using the UK Biobank resource (Application No. 41209). This work would have not been possible without the financial support provided by Cohen Veterans Bioscience, the Stanley Center for Psychiatric Genetics at the Broad Institute, and One Mind. This material has been reviewed by the Walter Reed Army Institute of Research. There is no objection to its presentation and/or publication. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting true views of the U.S. Department of the Army or the Department of Defense. We thank the investigators who comprise the PGC-PTSD working group and especially the more than 206,000 research participants worldwide who shared their life experiences and biological samples with PGC-PTSD investigators. We thank Mark Zervas for his critical input. Full acknowledgments are in Supplement 1. MBS has in the past 3 years received consulting income from Actelion, Acadia Pharmaceuticals, Aptinyx, Bionomics, BioXcel Therapeutics, Clexio, EmpowerPharm, GW Pharmaceuticals, Janssen, Jazz Pharmaceuticals, and Roche/Genentech and has stock options in Oxeia Biopharmaceuticals and Epivario. In the past 3 years, NPD has held a part-time paid position at Cohen Veterans Bioscience, has been a consultant for Sunovion Pharmaceuticals, and is on the scientific advisory board for Sentio Solutions for unrelated work. In the past 3 years, KJRe has been a consultant for Datastat, Inc. RallyPoint Networks, Inc. Sage Pharmaceuticals, and Takeda. JLM-K has received funding and a speaking fee from COMPASS Pathways. MU has been a consultant for System Analytic. HRK is a member of the Dicerna scientific advisory board and a member of the American Society of Clinical Psychopharmacology Alcohol Clinical Trials Initiative, which during the past 3 years was supported by Alkermes, Amygdala Neurosciences, Arbor Pharmaceuticals, Dicerna, Ethypharm, Indivior, Lundbeck, Mitsubishi, and Otsuka. HRK and JG are named as inventors on Patent Cooperative Treaty patent application number 15/878,640, entitled ?Genotype-guided dosing of opioid agonists,? filed January 24, 2018. RP and JG are paid for their editorial work on the journal Complex Psychiatry. OAA is a consultant to HealthLytix. All other authors report no biomedical financial interests or potential conflicts of interest. Publisher Copyright: © 2021 Society of Biological PsychiatryBackground: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime trauma exposure (LTE) information could enhance the discovery power of PTSD genome-wide association studies (GWASs). Methods: A GWAS on PTSD symptoms was performed in 51 cohorts followed by a fixed-effects meta-analysis (N = 182,199 European ancestry participants). A GWAS of LTE burden was performed in the UK Biobank cohort (N = 132,988). Genetic correlations were evaluated with linkage disequilibrium score regression. Multivariate analysis was performed using Multi-Trait Analysis of GWAS. Functional mapping and annotation of leading loci was performed with FUMA. Replication was evaluated using the Million Veteran Program GWAS of PTSD total symptoms. Results: GWASs of PTSD symptoms and LTE burden identified 5 and 6 independent genome-wide significant loci, respectively. There was a 72% genetic correlation between PTSD and LTE. PTSD and LTE showed largely similar patterns of genetic correlation with other traits, albeit with some distinctions. Adjusting PTSD for LTE reduced PTSD heritability by 31%. Multivariate analysis of PTSD and LTE increased the effective sample size of the PTSD GWAS by 20% and identified 4 additional loci. Four of these 9 PTSD loci were independently replicated in the Million Veteran Program. Conclusions: Through using a quantitative trait measure of PTSD, we identified novel risk loci not previously identified using prior case-control analyses. PTSD and LTE have a high genetic overlap that can be leveraged to increase discovery power through multivariate methods.publishersversionpublishe

Subjektivna procjena kvalitete života (WHOQOL-BREFF) u odnosu na neuroticizam (Cornell index)

It is generally agreed that personality variables have a relatively consistent influence on the subjective estimation of different situations in everyday life and the way people react to them. The aim of this review was to summarise our previously published findings on the relationship between subjective estimation of one’s quality of life and the personality trait neuroticism-emotional stability. We used the WHO Quality of Life - BREF or SF-36 questionnaires for the assessment of the quality of life, Cornell Index for the assessment of neuroticism, and The Social Readjustment Rating Scale for the evaluation of common stressors. Our results have shown that more emotionally stable participants (lower neuroticism) perceive their life better in quality and are more satisfied with their work environment. In addition, our results support the findings from other studies that women have higher neuroticism and lower quality of life scores than men.Općenito se smatra kako varijable ličnosti imaju važnu ulogu u relativno dosljednom utjecaju na subjektivnu procjenu različitih situacija u svakodnevnom životu, kao i na reakcije na te situacije. Cilj ovoga preglednog članka bio je objediniti naše objavljene rezultate o odnosu između subjektivne procjene kvalitete života i crte ličnosti neuroticizam - emocionalna stabilnost. Upotrijebljeni su WHOQOL-BREF ili SF-36 upitnici za procjenu kvalitete života, Cornell indeks za procjenu neuroticizma i The Social Readjustment Rating Scale za evaluaciju uobičajenih stresora. Dobiveni rezultati pokazali su kako osobe s izraženijom emocionalnom stabilnošću (manjim neuroticizmom) percipiraju svoj život kvalitetnijim te su zadovoljnije svojom radnom okolinom. Također je u skladu s drugim objavljenim studijama nađeno kako žene postižu više rezultate na skalama neuroticizma od muškaraca te niže rezultate na upitnicima kvalitete života

Global asymptotic behavior of yn+1 = (pyn + yn-1)/(r + qyn + yn-1)

We investigate the global stability character of the equilibrium points and the period-two solutions of yn+1 = (pyn + yn-1)/(r + qyn + yn-1), n = 0, 1,..., with positive parameters and nonnegative initial conditions. We show that every solution of the equation in the title converges to either the zero equilibrium, the positive equilibrium, or the period-two solution, for all values of parameters outside of a specific set defined in the paper. In the case when the equilibrium points and period-two solution coexist, we give a precise description of the basins of attraction of all points. Our results give an affirmative answer to Conjecture 9.5.6 and the complete answer to Open Problem 9.5.7 of Kulenović and Ladas, 2002

Basins of Attraction for Two-Species Competitive Model with Quadratic Terms and the Singular Allee Effect

We consider the following system of difference equations: xn+1=xn2/B1xn2+C1yn2, yn+1=yn2/A2+B2xn2+C2yn2,  n=0, 1, …,   where B1, C1, A2, B2, C2 are positive constants and x0, y0≥0 are initial conditions. This system has interesting dynamics and it can have up to seven equilibrium points as well as a singular point at (0,0), which always possesses a basin of attraction. We characterize the basins of attractions of all equilibrium points as well as the singular point at (0,0) and thus describe the global dynamics of this system. Since the singular point at (0,0) always possesses a basin of attraction this system exhibits Allee’s effect