Fast computation of the geoelectric field using the method of elementary current systems and planar Earth models

International audienceThe method of spherical elementary current systems provides an accurate modelling of the horizontal component of the geomagnetic variation field. The interpolated magnetic field is used as input to calculate the horizontal geoelectric field. We use planar layered (1-D) models of the Earth's conductivity, and assume that the electric field is related to the local magnetic field by the plane wave surface impedance. There are locations in which the conductivity structure can be approximated by a 1-D model, as demonstrated with the measurements of the Baltic Electromagnetic Array Research project. To calculate geomagnetically induced currents (GIC), we need the spatially integrated electric field typically in a length scale of 100km. We show that then the spatial variation of the electric field can be neglected if we use the measured or interpolated magnetic field at the site of interest. In other words, even the simple plane wave model is fairly accurate for GIC purposes. Investigating GIC in the Finnish high-voltage power system and in the natural gas pipeline, we find a good agreement between modelled and measured values, with relative errors less than 30% for large GIC values. Key words. Geomagnetism and paleomagnetism (geomagnetic induction; rapid time variations) ? Ionosphere (electric field and currents

SIFAT KIMIA TANAH PADA HUTAN MANGROVE DI DESA TOLAI BARAT KECEMATAN TORUE KABUPATEN PARIGI MOUTONG

Mangrove forest vegetation in Indonesia is known for its high species diversity. Diverse mangrove vegetation can provide a good contribution to the soil including soil chemical properties such as soil pH, C-organic, nitrogen, phosphorus, potassium and cation exchange capacity. This research was conducted from January to March 2019, located in the West Tolai Village, Torue District, Parigi Moutong Regency. The purpose of this study was to determine the chemical nature of the soil in mangrove forests in Tolai Barat Village, Torue District, Parigi Moutong Regency. The method used is the survey / observation method and soil sampling is done intentionally (purposive sampling). Sampling was carried out in 3 different conditions, which were always inundated, inundated at moderate tides and inundated at high tides at depths of 0-30 and 30-60 cm, and at each point 3 samples were taken so that a total of 18 samples were composite into 6 the sample. Soil samples are then analyzed in the soil science laboratory. The results of this study indicate that the chemical properties of the soil in the mangrove forest of Tolai Barat Village are very diverse in the three different location conditions, which are always inundated, flooded during medium tides and submerged during high tides with depths of 0-30 and 30-60 respectively. cm has a acidic and neutral soil pH with a value of 4.74 -7.46H2O, C-organic from very low to high 0.45-4.75%, N-Total from moderate to low 0.21-0.05%, P-available is very low 9.11-7.94 ppm, K-Total with low to moderate values 15.89-23.18mg100gr-1, Cation Exchange Capacity (CEC) is classified as very low to low 4.16 -5.88 (cmol (+) kg-1)

An educational intervention for NICU staff decreased maternal postpartum depression

BackgroundMothers of preterm infants are at increased risk for postpartum depression, which may disturb parenting and child development. Strategies for prevention are needed. Therefore, we evaluated how an educational intervention for neonatal staff affected depression symptoms among mothers of preterm infants.MethodsThe Close Collaboration with Parents intervention was implemented in the NICU at Turku University Hospital in Finland. Maternal depression was compared between the pre-intervention and post-intervention cohorts using the Edinburgh Postnatal Depression Scale. The eligible infants were born ≤1500 g without major anomalies and survived. Data were available from 145 and 93 mothers in the pre-intervention and post-intervention cohorts, respectively, at 4 and/or 6 months of corrected age.ResultsThe depression scores were significantly lower in the post-intervention cohort than in the pre-intervention cohort; the estimated difference was 2.54 points (95% CI, 1.24–3.83), p p = 0.066.ConclusionThe Close Collaboration with Parents intervention decreased depression symptoms among the mothers of very preterm infants. Systematic educational intervention targeted to the whole NICU staff can potentially prevent postnatal depression among mothers of preterm infants.</p

Absence of polysialylated NCAM is an unfavorable prognostic phenotype for advanced stage neuroblastoma

<p>Abstract</p> <p>Background</p> <p>The expression of a neural crest stem cell marker, polysialic acid (polySia), and its main carrier, neural cell adhesion molecule (NCAM), have been detected in some malignant tumors with high metastatic activity and unfavorable prognosis, but the diagnostic and prognostic value of polySia-NCAM in neuroblastoma is unclear.</p> <p>Methods</p> <p>A tumor tissue microarray (TMA) of 36 paraffin-embedded neuroblastoma samples was utilized to detect polySia-NCAM expression with a polySia-binding fluorescent fusion protein, and polySia-NCAM expression was compared with clinical stage, age, <it>MYCN </it>amplification status, histology (INPC), and proliferation index (PI).</p> <p>Results</p> <p>PolySia-NCAM-positive neuroblastoma patients had more often metastases at diagnosis, and polySia-NCAM expression associated with advanced disease (<it>P </it>= 0.047). Most interestingly, absence of polySia-NCAM-expressing tumor cells in TMA samples, however, was a strong unfavorable prognostic factor for overall survival in advanced disease (<it>P </it>= 0.0004), especially when <it>MYCN </it>was not amplified. PolySia-NCAM-expressing bone marrow metastases were easily detected in smears, aspirates and biopsies.</p> <p>Conclusion</p> <p>PolySia-NCAM appears to be a new clinically significant molecular marker in neuroblastoma, hopefully with additional value in neuroblastoma risk stratification.</p

Across Continents and Demographics, Unpredictable Maternal Signals are Associated with Children\u27s Cognitive Function

Background Early life experiences have persisting influence on brain function throughout life. Maternal signals constitute a primary source of early life experiences, and their quantity and quality during sensitive developmental periods exert enduring effects on cognitive function and emotional and social behaviors. Here we examined if, in addition to established qualitative dimensions of maternal behavior during her interactions with her infant and child, patterns of maternal signals may contribute to the maturation of children\u27s executive functions. We focused primarily on effortful control, a potent predictor of mental health outcomes later in life. Methods In two independent prospective cohorts in Turku, Finland (N = 135), and Irvine, CA, USA (N = 192) that differed significantly in race/ethnicity and sociodemographic parameters, we assessed whether infant exposure to unpredictable patterns of maternal-derived sensory signals portended poor effortful control. Outcomes In both the Irvine and Turku cohorts, unpredictable sequences of maternal behavior during infancy were associated with worse effortful control at one year of age. Longitudinal analyses demonstrated that this association persisted for as long as each cohort was assessed-until two years of age in the Turku cohort and to 9.5 years in the Irvine cohort. The relation of unpredictable maternal signals during infancy and the measures of executive function persisted after adjusting for covariates. Interpretations The consistency of our findings across two cohorts from different demographic backgrounds substantiated the finding that patterns, and specifically unpredictable sequences, of maternal behaviors may influence the development of executive functions which may be associated with vulnerability to subsequent psychopathology

Defining activities in neurovascular microsurgery training : entrustable professional activities for vascular neurosurgery

Background Entrustable professional activities (EPAs) represent an assessment framework with an increased focus on competency-based assessment. Originally developed and adopted for undergraduate medical education, concerns over resident ability to practice effectively after graduation have led to its implementation in residency training but yet not in vascular neurosurgery. Subjective assessment of resident or fellow performance can be problematic, and thus, we aim to define core EPAs for neurosurgical vascular training. Methods We used a nominal group technique in a multistep interaction between a team of experienced neurovascular specialists and a medical educator to identify relevant EPAs. Panel members provided feedback on the EPAs until they reached consent. Results The process produced seven core procedural EPAs for vascular residency and fellowship training, non-complex aneurysm surgery, complex aneurysm surgery, bypass surgery, arteriovenous malformation resection, spinal dural fistula surgery, perioperative management, and clinical decision-making. Conclusion These seven EPAs for vascular neurosurgical training may support and guide the neurosurgical society in the development and implementation of EPAs as an evaluation tool and incorporate entrustment decisions in their training programs.Peer reviewe

Infant fecal microbiota composition and attention to emotional faces

The gut microbiota has been suggested to influence neurodevelopment in rodents. Preliminary human studies have associated fecal microbiota composition with features of emotional and cognitive development as well as differences in thalamus-amygdala connectivity. Currently, microbiota-gut-brain axis studies cover heterogenous set of infant and child brain developmental phenotypes, while microbiota associations with more fine-grained aspects of brain development remain largely unknown. Here (N = 122, 53% boys), we investigated the associations between infant fecal microbiota composition and infant attention to emotional faces, as bias for faces is strong in infancy and deviations in early processing of emotional facial expressions may influence the trajectories of social-emotional development. The fecal microbiota composition was assessed at 2.5 months of age and analyzed with 16S rRNA gene sequencing. Attention to emotional faces was assessed with an age-appropriate face-distractor paradigm, using neutral, happy, fearful, and scrambled faces and salient distractors, at 8 months of age. We observed an association between a lower abundance of Bifidobacterium and a higher abundance of Clostridium with an increased “fear bias,” that is, attention toward fearful versus happy/neutral faces. This data suggests an association between early microbiota and later fear bias, a well-established infant phenotype of emotionally directed attention. However, the clinical significance or causality of our findings remains to be assessed

EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis

BACKGROUND: Ephrin receptor B2 (EPHB2) has recently been proposed as a novel tumor suppressor gene in colorectal cancer (CRC). Inactivation of the gene has been shown to correlate with progression of colorectal tumorigenesis, and somatic mutations have been reported in both colorectal and prostate tumors. METHODS: Here we have analyzed the EPHB2 gene for germline alterations in 101 individuals either with 1) CRC and a personal or family history of prostate cancer (PC), or 2) intestinal hyperplastic polyposis (HPP), a condition associated with malignant degeneration such as serrated adenoma and CRC. RESULTS: Four previously unknown missense alterations were observed, which may be associated with the disease phenotype. Two of the changes, I361V and R568W, were identified in Finnish CRC patients, but not in over 300 Finnish familial CRC or PC patients or more than 200 population-matched healthy controls. The third change, D861N, was observed in a UK HPP patient, but not in additional 40 UK HPP patients or in 200 UK healthy controls. The fourth change R80H, originally identified in a Finnish CRC patient, was also found in 1/106 familial CRC patients and in 9/281 healthy controls and is likely to be a neutral polymorphism. CONCLUSION: We detected novel germline EPHB2 alterations in patients with colorectal tumors. The results suggest a limited role for these EPHB2 variants in colon tumor predisposition. Further studies including functional analyses are needed to confirm this