Seasonal variations of sexual activity of local bucks in western Algeria

The aim of the present study was to evaluate the seasonal variation of sexual activity among bucks of local breed (Arbia) in western Algeria. The experiment was carried out using eight bucks aged between 4 and 6 years, a group of males in their pre-puberty age (4 to 6 months) and two females. Animals were kept in a building during one year and fed with a constant ration of wheat and hay with free access to water. Sexual activity was evaluated by scrotal circumference and sexual behaviour analysis. Results showed that the monthly average of scrotal circumference was high during August and September (27.58 ± 0.16 and 27.67 ± 0.17 cm, respectively) and low during April and May (25.18 ± 0.11 and 25.25 ±0.17 cm, respectively). Monthly averages of sexual behaviour followed similar evolution. When the season of the year is considered, sexual behaviour and scrotal circumference presented significant variations. The two parameters are maximal during autumn (7.96 ± 1.28 and 26.89 ± 0.55 cm, respectively) and go down during winter (6.09 ± 1.25 and 25.65 ± 0.27 cm, respectively) to reach minimal values during spring (4.89 ± 1.66 and 25.41 ± 0.37 cm, respectively) then they go up during summer. Inconclusion, bucks of local breed in western Algeria have seasonal variations of sexual activity in relation to annual photoperiod variation; short days stimulate the sexual activity whereas long days inhibit it

Synthesis, Metal Ions Coordination, Antimicrobial Activity of Some L-Tartaric Acid Derivatives

Abstract: The bis-1,3,4-oxadiazole-thione and bis-4-amino-1,2,4-triazole-thiol derivatives from L-tartaric acid were synthesized. The synthetic intermediates, ester, hydrazide and oxadiazole derivatives have shown a significant tendency to form complexes with Fe(III), Ni(II) and Cu(II) ions. The formation of complexes with metals was detected by UV-Vis and IR spectroscopy. A novel complex nucleoside from bis-4-amino-1,2,4-triazole-thiol derivative with l-arabinose was also synthesized. The antimicrobial activity for final and synthetic intermediates in vitro against the microorganisms: Escherichia coli, Pseudomonas aeruginosa, Yersinia pseudotuberculosis, Enterococcus faecalis, Staphylococcus aureus and Candida albicans were examined and some products showed noticeable activity against the tested microorganisms

Metastase axillaire d'un carcinome papillaire de la thyroïde: À propos d'un cas

Les métastases axillaires dans le cadre d'un cancer de la thyroïde sont extrêmement rares. Plusieurs hypothèses expliquent ce drainage. Nousrapportons le cas d'un patient de 78 ans ayant pour antécédents  chirurgicaux une lobo-isthmectomie en 1987, puis une totalisation chirurgicale en 1997 non documentés, admis en septembre 2008 pour exploration d'une masse latéro-cervicale gauche. Le reste de l'examen clinique révèle la présence de multiples adénopathies axillaires bilatérales. La biopsie exérèse d'une adénopathie axillaire droite (côté controlatéral) retrouve une métastase ganglionnaire d'un carcinome papillaire de la thyroïde avec effraction capsulaire. La tomodensitométrie cervico-thoracique note la présence d'un processus tumoral latéro-cervical gauche, un lobe thyroïdien droit siège de multiples nodules hypodenses, des adénopathies cervicales et axillaires et des lésions suspectes au niveau du parenchyme pulmonaire. Une thyroïdectomie totale avec curage  ganglionnaire cervical est décidée, complétée par une ablation des ganglions axillaires macroscopiquement atteints. Des cures d'iode  radioactif (IRA-thérapie) sont indiquées. Bien qu'exceptionnelle, la  présence de métastases axillaires d'un carcinome thyroïdien est de  pronostic péjoratif. On se demande alors si ces patients ne nécessitent pas une prise en charge particulière. Une réflexion à une stratégie  thérapeutique est donc nécessaire

The spatial variability of water quality in the Mediterranean of eastern Morocco

Thirty sampling stations were surveyed each season during the period 2013-2015 in the objective to determine the water quality in the coastal areas between Saidia and Cala Iris. The CPA Analysis shows 5 groups associated following the water quality of 12 components. Only the sites close to the agglomerations bordering the lagoon of Nador and Al Hoceima show high values of BOD5, Nitrites and PO4. This deterioration of the water quality observed in some coastal sites explains in large part their low richness of the biodiversity of the algae

Warburg-like effect is a hallmark of complex I assembly defects

Due to its pivotal role in NADH oxidation and ATP synthesis, mitochondrial complex I (CI) emerged as a crucial regulator of cellular metabolism. A functional CI relies on the sequential assembly of nuclear- and mtDNA-encoded subunits; however, whether CI assembly status is involved in the metabolic adaptations in CI deficiency still remains largely unknown. Here, we investigated the relationship between CI functions, its structure and the cellular metabolism in 29 patient fibroblasts representative of most CI mitochondrial diseases. Our results show that, contrary to the generally accepted view, a complex I deficiency does not necessarily lead to a glycolytic switch, i.e. the so-called Warburg effect, but that this particular metabolic adaptation is a feature of CI assembly defect. By contrast, a CI functional defect without disassembly induces a higher catabolism to sustain the oxidative metabolism. Mechanistically, we demonstrate that reactive oxygen species overproduction by CI assembly intermediates and subsequent AMPK-dependent Pyruvate Dehydrogenase inactivation are key players of this metabolic reprogramming. Thus, this study provides a two-way-model of metabolic responses to CI deficiencies that are central not only in defining therapeutic strategies for mitochondrial diseases, but also in all pathophysiological conditions involving a CI deficiency

CLUH couples mitochondrial distribution to the energetic and metabolic status

Mitochondrial dynamics and distribution are critical for supplying ATP in response to energy demand. CLUH is a protein involved in mitochondrial distribution whose dysfunction leads to mitochondrial clustering, the metabolic consequences of which remain unknown. To gain insight into the role of CLUH on mitochondrial energy production and cellular metabolism, we have generated CLUH-knockout cells using CRISPR/Cas9. Mitochondrial clustering was associated with a smaller cell size and with decreased abundance of respiratory complexes, resulting in oxidative phosphorylation (OXPHOS) defects. This energetic impairment was found to be due to the alteration of mitochondrial translation and to a metabolic shift towards glucose dependency. Metabolomic profiling by mass spectroscopy revealed an increase in the concentration of some amino acids, indicating a dysfunctional Krebs cycle, and increased palmitoylcarnitine concentration, indicating an alteration of fatty acid oxidation, and a dramatic decrease in the concentrations of phosphatidylcholine and sphingomyeline, consistent with the decreased cell size. Taken together, our study establishes a clear function for CLUH in coupling mitochondrial distribution to the control of cell energetic and metabolic status

Melissopalynological, physicochemical and antioxidant properties of honey from West Coast of Malaysia

Stingless bees are native to tropical region and produce honey which are high in moisture content. Compared to honey from honeybees, there are limited studies on honey derived from stingless bees. Hence, the aim of this study was to evaluate the chemical composition and antioxidant activities of stingless bee honey. Fifteen types of honey were collected from six states in West Coast of Malaysia and pollen analyses were carried out. Four types of unifloral honey samples produced by stingless bees were selected to determine their physicochemical and antioxidant activities including total phenolic, total flavonoid and ascorbic acid contents. Melissopalynological study of 15 honey samples collected from different states showed presence of both unifloral and multifloral origins. Honey samples collected from Apis mellifera (honeybee) combs had lower number of total pollen compared to samples collected from Heterotrigona itama and Geniotrigona thoracica (stingless bees). Jambul Merak honey contains the highest phenolic and flavonoid contents with greatest color intensity and has the highest antioxidant potential. This study highlights the chemical composition and biological activity of honey from stingless bees which may increase its commercial value or to be utilised as potential functional food ingredient

Analysis by detached leaf assay of components of partial resistance of faba bean (Vicia faba L.) to chocolate spot caused by Botrytis fabae Sard.

Five faba bean (Vicia faba L.) genotypes with different levels of field susceptibility to chocolate spot caused by Botrytis fabae, were analysed for the components of partial resistance in a laboratory assay on living detached leaves. The incubation period (IP), the number of spots (NP), the lesion diameter (LD), the latency period (LP) and the number of spores/leaflet (NS), were determined and statistically analysed. Parameters LD, LP and NS were involved in characterising partial resistance, but IP did not appear to play a role. NS did not become a significant factor until 20 h after inoculation. Genotype FRY167 was most resistant with the lowest LD and NS values and the longest LP. In contrast, FRY30 had the highest level of susceptibility, with the highest LD and NS and the shortest LP. However, the resistant control BPL710 showed a slight deviation in that it expressed a long LP which was not significantly different from the values of the susceptible control Aguadulce. The absence of a correlation between LP and NS in BPL710 opens a discussion on the genetic control of its resistance

CELLULITE ORBITAIRE REVELANT UN OSTEOME FRONTAL

Les ostéomes des cavités naso-sinusiennes sont des tumeurs bénignes relativement rares dont la gravité tient à l’extension orbitaire et endocranienne. Nous rapportons le cas d’une patiente de 33 ans admise pour une cellulite orbitaire gauche compliquant un ostéome frontal. L’imagerie a permis le diagnostic positif et le choix de la voie d’abord. Les indications thérapeutiques dépendent essentiellement du volume tumoral, de l’évolutivité des lésions et de l’apparition de complications