P.E. Strzelecki, Australian explorer, 1797-1873.

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Preparation and characterization of Bi26–2xMn2xMo10O69-d and Bi26.4Mn0.6Mo10–2yMe2yO69-d(Me = V, Fe) solid solutions

Received: 06.06.2017; accepted: 23.06.2017; published: 14.07.2017.Single phase samples of bismuth molybdate, Bi26Mo10O69, doped with Mn on the bismuth sublattice and V, Fe on the molybdenum sublattice were found to crystallize in the triclinic Bi26Mo10O69 structure at low doping levels and in the monoclinic Bi26Mo10O69 structure - at higher dopant concentration. The assumption that all Mn ions have an oxidation state of +2 was confirmed by means of magnetic measurement results analysis using Curie-Weiss law. Conductivity was investigated using impedance spectroscopy. The conductivity of Bi26.4Mn0.6Mo9.6Fe0.4O69-d was 1.2*10-2 S*cm-1 at 973 K and 2.2*10-4 S*cm-1 at 623 K, and the conductivity of Bi26.4Mn0.6Mo9.2V0.8O69-d was 2.2*10-3 S*cm-1 at 973 K and 2.2*10-5 S*cm-1 at 623 K

BOLLOCKS!! Designing pervasive games that play with the social rules of built environments

We propose that pervasive games designed with mechanics that are specifically in opposition with, or disruptive of, social rules of the environment in which they are played, have unique potential to provide interesting, provocative experiences for players. We explore this concept through the design and evaluation of an experimental game prototype, Shhh!, inspired by the juvenile game Bollocks, and implemented on Android mobile devices, which challenges players to make loud noises in libraries. Six participants played the game before engaging in semi-structured interviews, explored through inductive thematic analysis. Results suggest that the game provoked in players a heightened awareness of social rules, as well as a complex social dilemma of whether or not to act. We conclude by presenting a model for designing games that play with the social, as well as physical, rules of the environments in which they are set

Use of Most Bothersome Symptom as a Coprimary Endpoint in Migraine Clinical Trials: A Post-Hoc Analysis of the Pivotal ZOTRIP Randomized, Controlled Trial.

ObjectiveTo better understand the utility of using pain freedom and most bothersome headache-associated symptom (MBS) freedom as co-primary endpoints in clinical trials of acute migraine interventions.BackgroundAdhesive dermally applied microarray (ADAM) is an investigational system for intracutaneous drug administration. The recently completed pivotal Phase 2b/3 study (ZOTRIP), evaluating ADAM zolmitriptan for the treatment of acute moderate to severe migraine, was one of the first large studies to incorporate MBS freedom and pain freedom as co-primary endpoints per recently issued guidance by the US Food and Drug Administration. In this trial, the proportion of patients treated with ADAM zolmitriptan 3.8 mg, who were pain-free and MBS-free at 2 hours post-dose, was significantly higher than for placebo.MethodsWe undertook a post-hoc analysis of data from the ZOTRIP trial to examine how the outcomes from this trial compare to what might have been achieved using the conventional co-primary endpoints of pain relief, nausea, photophobia, and phonophobia.ResultsOf the 159 patients treated with ADAM zolmitriptan 3.8 mg or placebo, prospectively designated MBS were photophobia (n = 79), phonophobia (n = 43), and nausea (n = 37). Two-hour pain free rates in those with photophobia as the MBS were 36% for ADAM zolmitriptan 3.8 mg and 14% for placebo (P = .02). Corresponding rates for those with phonophobia as the MBS were 14% and 41% (P = .05). For those whose MBS was nausea, corresponding values were 56% and 16%, respectively (P = .01). Two-hour freedom from the MBS for active drug vs placebo were 67% vs 35% (P < .01) for photophobia, 55% vs 43% (P = .45) for phonophobia, and 89% vs 58% for nausea (P = .04). MBS freedom but not pain freedom was achieved in 28%. Only 1 patient (1%) achieved pain freedom, but not MBS freedom. The proportion with both pain and MBS freedom was highest (56%) among those whose MBS was nausea.ConclusionIn this study, the use of MBS was feasible and seemed to compare favorably to the previously required 4 co-primary endpoints

Space VLBI Observations of 3C371

We present the first space VLBI observations of 3C~371, carried out at a frequency of 4.8 GHz. The combination of the high resolution provided by the orbiting antenna Highly Advanced Laboratory for Communications and Astronomy (HALCA) and the high sensitivity of the VLBA allows imaging of the jet of 3C~371 with an angular resolution of approximately 0.26 mas, which for this relatively nearby source corresponds to $\sim$ 0.4 h$^{-1}$ pc. Comparison between two epochs separated by 66 days reveals no apparent motions in the inner 7 mas jet structure above an upper limit of $\sim 1.4 h^{-1}$ c. This value, the absence of detectable counterjet emission from the presumably symmetric jet, plus the presence of extended double-lobe structure, are consistent with the knots in the jet being stationary features such as standing shocks. The jet intensity declines with the angular distance from the core as $\phi^{-1.68}$. This is more gradual than that derived for 3C~120, $\phi^{-1.86}$, for which there is evidence for strong intereactions between the jet and ambient medium. This suggests that in 3C~371 there is a greater level of {\it in situ} acceleration of electrons and amplification of magnetic field. We interpret sharp bends in the jet at sites of off-center knots as further evidence for the interaction between the jet and external medium, which may also be responsible for the generation of standing recollimation shocks. These recollimation shocks may be responsible for the presumably stationary components. The radio properties of 3C~371 are intermediate between those of other radio galaxies with bright cores and those of BL Lacertae objects.Comment: 5 pages, 4 figures. Accepted for publication in Ap