Glyco-biomarkers: Potential determinants of cellular physiology and pathology

Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly, and with it the far reaching clinical implications are becoming understood. Recent advances in high-throughput glycomic techniques, glyco biomarker profiling, glyco-bioinformatics and development of increasingly sophisticated glyco-arrays, combined with our increased understanding of the molecular details of glycosylation have facilitated the linkage between aberrant glycosylation and human diseases, and highlighted the possibility of using glyco-biomarkers as potential determinants of disease and its progression. The focus of this review is to give an insight into the biological significance of these glycomodifications, highlight some specific examples of glyco-biomarkers in relation to autoimmunity and in particular rheumatoid arthritis, and to explore the exciting possibility of exploiting these for diagnostic and prognostic strategies

A simultaneous planar laser-induced fluorescence, particle image velocimetry and particle tracking velocimetry technique for the investigation of thin liquid-film flows

AbstractA simultaneous measurement technique based on planar laser-induced fluorescence imaging (PLIF) and particle image/tracking velocimetry (PIV/PTV) is described for the investigation of the hydrodynamic characteristics of harmonically excited liquid thin-film flows. The technique is applied as part of an extensive experimental campaign that covers four different Kapitza (Ka) number liquids, Reynolds (Re) numbers spanning the range 2.3–320, and inlet-forced/wave frequencies in the range 1–10Hz. Film thicknesses (from PLIF) for flat (viscous and unforced) films are compared to micrometer stage measurements and analytical predictions (Nusselt solution), with a resulting mean deviation being lower than the nominal resolution of the imaging setup (around 20μm). Relative deviations are calculated between PTV-derived interfacial and bulk velocities and analytical results, with mean values amounting to no more than 3.2% for both test cases. In addition, flow rates recovered using LIF/PTV (film thickness and velocity profile) data are compared to direct flowmeter readings. The mean relative deviation is found to be 1.6% for a total of six flat and nine wavy flows. The practice of wave/phase-locked flow-field averaging is also implemented, allowing the generation of highly localized velocity profile, bulk velocity and flow rate data along the wave topology. Based on this data, velocity profiles are extracted from 20 locations along the wave topology and compared to analytically derived ones based on local film thickness measurements and the Nusselt solution. Increasing the waviness by modulating the forcing frequency is found to result in lower absolute deviations between experiments and theoretical predictions ahead of the wave crests, and higher deviations behind the wave crests. At the wave crests, experimentally derived interfacial velocities are overestimated by nearly 100%. Finally, locally non-parabolic velocity profiles are identified ahead of the wave crests; a phenomenon potentially linked to the cross-stream velocity field

A Comparison of Inlet Valve Operating Strategies in a Single-Cylinder Spark-Ignition Engine

This experimental work was concerned with comparison of inlet valve actuation strategies in a thermodynamic single cylinder spark ignition research engine equipped with a mechanical fully variable valvetrain on both the inlet and exhaust. The research involved study of the effects of the valvetrain on combustion, fuel economy and emissions when used to achieve variable valve timing alone and when applied together with early inlet valve closing for so-called unthrottled operation. The effects of such early inlet valve closure were examined using either fully variable events or by simulating two-stage cam profile switching. While fully variable operation enabled the maximum fuel savings over the widest operating map, it was apparent that two-stage switching mechanisms can provide an attractive compromise in terms of cost versus CO 2 benefit on engines of moderate to large capacity. However, from speed-load maps obtained in the current study it would appear that a wide range of inlet valve durations would be necessary to obtain fuel savings sufficient to warrant a system any more sophisticated than current variable valve timing mechanisms in future aggressively downsized gasoline engines. © IMechE, 2009

On The Relevance Of Fair Sampling Assumption In The Recent Bell Photonic Experiments

In the experimental verification of Bell's inequalities in real photonic experiments, it is generally believed that the so-called fair sampling assumption (which means that a small fraction of results provide a fair statistical sample) has an unavoidable role. Here, we want to show that the interpretation of these experiments could be feasible, if some different alternative assumptions other than the fair sampling were used. For this purpose, we derive an efficient Bell-type inequality which is a CHSH-type inequality in real experiments. Quantum mechanics violates our proposed inequality, independent of the detection-efficiency problems.Comment: 13 pages, no figure, one table. Last versio

Community College Culture and Faculty of Color

This investigation examines and explains the ways in which community college faculty of color construct their understandings of institutional culture. We investigate four community colleges in California through interviews with 31 full-time faculty of color. This faculty group expresses identity conflicts between their professional roles and their cultural identities. Their understandings of their institutions suggest that the culture of the community college is more complex and multi-faceted than that portrayed in the scholarly literature, which often portrays the institution as homogeneous and the faculty body as uniform. © The Author(s) 2013

“Dangerous Work”: Improving Conditions for Faculty of Color in the Community College

This qualitative investigation of the experiences of faculty of color at community colleges identifies current conditions for this population and suggests potentials for ameliorating conditions that inhibit their job satisfaction. We argue that the current conditions for faculty of color, based upon their expressed experiences at the community colleges, are deleterious to their professional performance, to their positive self-image, and to their contributions to their institutions. Alterations to these current conditions are unlikely without systemic institutional change. Indeed, without improvement to these conditions, the job satisfaction of faculty of color is not likely to change

The Divided Self: The Double Consciousness of Faculty of Color in Community Colleges

Through qualitative field methods research addressing faculty of color in four California community colleges, this investigation examines and explains faculty experiences and professional sense making. By combining critical race theory with social identity theory, our perspective underlines the potential social and ethnic identity conflicts inherent in the daily lives of faculty of color. The professional and social identities of faculty of color are not necessarily compatible, leading to a condition of "double consciousness," or what we refer to as "the divided self." © The Author(s) 2013

Bell's inequality tests: from photons to B-mesons

We analyse the recent claim that a violation of a Bell's inequality has been observed in the $B$--meson system [A. Go, {\em Journal of Modern Optics} {\bf 51} (2004) 991]. The results of this experiment are a convincing proof of quantum entanglement in $B$--meson pairs similar to that shown by polarization entangled photon pairs. However, we conclude that the tested inequality is not a genuine Bell's inequality and thus cannot discriminate between quantum mechanics and local realistic approaches.Comment: 5 page