Vergleich und Kombination unterschiedlicher Methoden zur Erhöhung der Sekundärionen-Ausbeute von Molekülschichten bei der Sekundärionenmassenspektrometrie

Es wurden verschiedene Methoden zur Steigerung der Sekundärionen (SI)-Ausbeute bei der SIMS einzeln und in Kombination untersucht. Das Hauptaugenmerk lag auf den Methoden, deren Funktionsweise auf der Erhöhung der oberflächennah deponierten Energiemenge basieren. Die experimentellen Ergebnisse wurden mit theoretisch berechneten Kenngrößen (z.B. Bremsvermögen) verglichen. Als Zusammenhang wurde eine Potenzfunktion ermittelt, für deren Exponent eine vom Probenaufbau abhängige Abschätzung gefunden wurde. Es konnte gezeigt werden, dass auch die Funktionsweise der MetA-SIMS hauptsächlich auf dem oberflächennahen Energieeintrag beruht. Auf Basis der ermittelten Zusammenhänge ist es nun möglich, die durch Anwendung der hier verwendeten Methoden erzielbaren Steigerung der SI-Ausbeute schon bei der Planung eines SIMS-Experimentes quantitativ abzuschätzen und zu entscheiden, ob diese Steigerungen den zeitlichen und finanziellen Aufwand und die Inkaufnahme etwaiger negativer Effekte rechtfertigt

Dissolved gas separation for engineered anaerobic wastewater systems

Dissolved gases produced within engineered anaerobic processes subsequently create a fugitive emission which can have financial, environmental and health and safety implications. Whilst desorption technology has been used to control dissolved gases in the drinking water sector, there is considerably less understanding of its deployment in wastewater for which there are numerous existing and emerging challenges. This review therefore focuses on existing and proposed technological approaches to gas desorption in engineered anaerobic wastewater processes, with specific emphasis on technology compatibility and downstream gas phase management. Simplified engineered solutions such as diffused aeration and multi-tray aerators appear robust solutions for implementation into wastewater. However, these processes are characterised by a low mass transfer coefficient and require high gas to liquid ratios (G/L) to achieve reasonable separation, which suggests their suitability is limited to small scale applications, in which gas recovery is not a priority. Packed columns and membrane contactors afford process intensification through increasing interfacial area which favours large scale applications; although both will require prefiltration technology to obviate media clogging. Vacuum or steam is the preferred driving force for separation when gas recovery is sought, while sweep-gas is energetically favoured. Sweep-gas has been used for gas recovery by operating at G/L toward the equilibrium value, which somewhat constrains mass transfer. Process selection must therefore be weighted on whole life cost, but will also be dependent upon process scale, financial (e.g. incentivisation) and non-financial (e.g. carbon) instruments, which are strongly influenced by regional policy

The Utility of Functional Movement Assessment on NBA Players

Professional basketball related injuries have not declined over the last decade despite improvements in training and conditioning or medical advancements in diagnostics, surgery, or rehabilitation. A descriptive epidemiological study of 80% of the National Basketball Association (NBA) teams over 17 years reported an injury incidence of 19.1 per 1000 athlete exposures, and 59,179 games missed due to injury. Starkey found that the there has been a 12.4% increase in game-related injuries in the NBA in a 10-year period from the 1988 - 1997 seasons. It is suspected that increased contact within the NBA along with improved player athleticism, size, power, and speed have contribute to the rise in injuries. The most commonly reported injuries in the NBA as reported via the greatest number of days missed include ankle sprains, patellofemoral inflammation, knee sprains, and lumbar strains. Recent trends involve less focus on specific physical or clinical measures and increased attention on the assessment of functional movement patterns for the purpose of predicting the likelihood of injury. The Functional Movement Screen (FMSTM) was introduced as a pre-participation examination intended to evaluate the quality of seven basic movement patterns that require a balance of both mobility and stability. The functional movements tested include: deep squat, hurdle step, in-line lunge, shoulder mobility, active straight leg raise, trunk stability push-up, and rotary stability. It is designed to assess the extremes of specific movements and positions for the purpose of identifying potential limitation, compensation, and asymmetry in individuals without obvious pathology. Recent literature has linked this screen to injury prediction in numerous populations that may be predisposed to injury, including professional football players, firefighters, collegiate female athletes, elite track and field athletes, military personnel. The majority of reliability studies conclude that the FMSTM has good intra-rater reliability. While some researchers conclude that reliability increases with additional training and clinical experience, others claim that the FMS intra-rater reliability was not improved with FMS certification. Inter- rater reliability was reported in recent studies to range from moderate and good to high. The Y-balance Test (YBT) is pre-participation assessment used to screen individuals who may have potential for lower extremity injury. This test involves the examination of dynamic balance and postural control. While research is still lacking regarding the validity and utility of the YBT-LQ, the SEBT has been reported to have a moderate to strong effect size and that this test was reliable and valid as a dynamic predictor to lower extremity injuries. No studies have investigated the outcomes of YBT as an injury predictor in professional basketball athletes or the relationship of these factors with functional movement screens.https://ecommons.udayton.edu/dpt_symposium/1011/thumbnail.jp

Use of Vibrio cholerae Vaccine in an Outbreak in Guinea

Producción CientíficaThe use of vaccines to prevent and control cholera is currently under debate. Shanchol is one of the two oral cholera vaccines prequalified by the World Health Organization; however, its effectiveness under field conditions and the protection it confers in the first months after administration remain unknown. The main objective of this study was to estimate the short-term effectiveness of two doses of Shanchol used as a part of the integrated response to a cholera outbreak in Africa. METHODS We conducted a matched case-control study in Guinea between May 20 and October 19, 2012. Suspected cholera cases were confirmed by means of a rapid test, and controls were selected among neighbors of the same age and sex as the case patients. The odds of vaccination were compared between case patients and controls in bivariate and adjusted conditional logistic-regression models. Vaccine effectiveness was calculated as (1-odds ratio) × 100. RESULTS Between June 8 and October 19, 2012, we enrolled 40 case patients and 160 controls in the study for the primary analysis. After adjustment for potentially confounding variables, vaccination with two complete doses was associated with significant protection against cholera (effectiveness, 86.6%; 95% confidence interval, 56.7 to 95.8; P=0.001). CONCLUSIONS In this study, Shanchol was effective when used in response to a cholera outbreak in Guinea. This study provides evidence supporting the addition of vaccination as part of the response to an outbreak. It also supports the ongoing efforts to establish a cholera vaccine stockpile for emergency use, which would enhance outbreak prevention and control strategies

Characterisation of physico-mechanical properties and degradation potential of calcium alginate beads for use in embolisation

High molecular weight alginate beads with 59% mannuronic acid content or 68% guluronic acid were prepared using a droplet generator and crosslinked in calcium chloride. The alginate beads were compared to current embolisation microspheres for compressibility and monitored over 12 weeks for size and weight change at 37°C in low volumes of ringers solutions. A sheep uterine model was used to analyse bead degradation and inflammatory response over 12 weeks. Both the in vitro and in vivo data show good delivery, with a compressibility similar to current embolic beads. In vitro, swelling was noted almost immediately and after 12 weeks the first signs of degradation were noted. No difference was noted in vivo. This study has shown that high molecular weight alginate gel beads were well tolerated by the body, but beads associated with induced thrombi were susceptible to inflammatory cell infiltration. The beads were shown to be easy to handle and were still observable after 3 months in vivo. The beads were robust enough to be delivered through a 2.7 Fr microcatheter. This study has demonstrated that high molecular weight, high purity alginate bead can be considered as semi-permanent embolisation beads, with the potential to bioresorb over time

Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe

<p>Abstract</p> <p>Background</p> <p>The objective of these two GCP multicentre European clinical field studies was to evaluate the long-term efficacy and safety of a new imidacloprid/flumethrin collar (Seresto^®, Bayer AnimalHealth, Investigational Veterinary Product(IVP)) in dogs and cats naturally infested with fleas and/or ticks in comparison to a dimpylat collar ("Ungezieferband fuer Hunde/fuer Katzen", Beaphar, Control Product (CP)).</p> <p>Methods</p> <p>232 (IVP) and 81 (CP) cats and 271(IVP) and 129 (CP) dogs were treated with either product according to label claims and formed the safety population. Flea and tick counts were conducted in monthly intervals for up to 8 months in the efficacy subpopulation consisting of 118 (IVP) + 47 (CP) cats and 197 (IVP) + 94 (CP) dogs. Efficacy was calculated as reduction of infestation rate within the same treatment group and statistically compared between the two treatment groups.</p> <p>Results</p> <p>Preventive efficacy against fleas in cats/dogs varied in the IVP group between 97.4%/94.1% and 100%/100% (overall mean: 98.3%/96.7%) throughout the 8 month period and in the CP group between 57.1%/28.2% and 96.1%/67.8% (overall mean: 79.3%/57.9%). Preventive efficacy against ticks in cats/dogs varied in the IVP group between 94.0%/91.2% and 100%/100% (overall mean: 98.4%/94.7%) throughout the 8 month period and in the CP group between 90.7%/79.9% and 100%/88.0% (overall mean: 96.9%/85.6%). The IVP group was statistically non-inferior to the CP group, and on various assessment days, statistical superiority was proven for flea and tick count reduction in dogs and cats. Both treatments proved to be safe in dogs and cats with mainly minor local observations at the application site. There was moreover, no incidence of any mechanical problem with the collar in dogs and cats during the entire study period.</p> <p>Conclusions</p> <p>The imidacloprid/flumethrin collar proved to reduce tick counts by at least 90% and flea counts by at least 95% for a period of at least 7-8 months in cats and dogs under field conditions. Therefore, it can be used as sustainable long-term preventative, covering the whole flea and tick season.</p

Transcranial Low-Level Laser Therapy Improves Neurological Performance in Traumatic Brain Injury in Mice: Effect of Treatment Repetition Regimen

Low-level laser (light) therapy (LLLT) has been clinically applied around the world for a spectrum of disorders requiring healing, regeneration and prevention of tissue death. One area that is attracting growing interest in this scope is the use of transcranial LLLT to treat stroke and traumatic brain injury (TBI). We developed a mouse model of severe TBI induced by controlled cortical impact and explored the effect of different treatment schedules. Adult male BALB/c mice were divided into 3 broad groups (a) sham-TBI sham-treatment, (b) real-TBI sham-treatment, and (c) real-TBI active-treatment. Mice received active-treatment (transcranial LLLT by continuous wave 810 nm laser, 25 mW/cm[superscript 2], 18 J/cm[superscript 2], spot diameter 1 cm) while sham-treatment was immobilization only, delivered either as a single treatment at 4 hours post TBI, as 3 daily treatments commencing at 4 hours post TBI or as 14 daily treatments. Mice were sacrificed at 0, 4, 7, 14 and 28 days post-TBI for histology or histomorphometry, and injected with bromodeoxyuridine (BrdU) at days 21–27 to allow identification of proliferating cells. Mice with severe TBI treated with 1-laser Tx (and to a greater extent 3-laser Tx) had significant improvements in neurological severity score (NSS), and wire-grip and motion test (WGMT). However 14-laser Tx provided no benefit over TBI-sham control. Mice receiving 1- and 3-laser Tx had smaller lesion size at 28-days (although the size increased over 4 weeks in all TBI-groups) and less Fluoro-Jade staining for degenerating neurons (at 14 days) than in TBI control and 14-laser Tx groups. There were more BrdU-positive cells in the lesion in 1- and 3-laser groups suggesting LLLT may increase neurogenesis. Transcranial NIR laser may provide benefit in cases of acute TBI provided the optimum treatment regimen is employed.National Institutes of Health (U.S.) (Grant R01AI050875)Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006)United States. Dept. of Defense. Congressionally Directed Medical Research Programs (W81XWH-09-1-0514)United States. Air Force Office of Scientific Research. Military Photomedicine Program (FA9550-11-1-0331

Improvisation as a creative dialogue

Our paper will describe the creative process of Zaum: Beyond Mind an interactive sound theater performance, and examine the role of improvisation in shaping the piece. Zaum is a modular performance for voice, bandoneon, piano and electronics- integrating both live interactive elements and fixed sounds – with lighting, and video projection. While the creative process included traditional modes of composition, a significant aspect in melding the contribution of two composers - each with a different approach to composition - shares important attributes with improvisation. It is to do with creative listening, adjusting our individual contribution in response to changing contexts, and developing a shared sense of musical pacing and narrative. Improvisation also played a significant role in developing the technological, interactive elements of the piece with a co-evolution of the programming and the performance over a lengthy process of exploration and adjustments. This process, therefore, entails multiple dialogues, musical as well as verbal, between us as a duo and between us and our instruments. On the way we discovered that analytical reflection, despite its connotations of cerebral processes popularly portrayed as in opposition to the spontaneity required in improvisation, played a crucial role in the shaping of the piece