Impact of wearable physical activity monitoring devices with exercise prescription or advice in the maintenance phase of cardiac rehabilitation: systematic review and meta-analysis

BackgroundPhysical activity (PA) is a component of cardiac rehabilitation (CR). However, life-long engagement in PA is required to maintain benefits gained. Wearable PA monitoring devices (WPAM) are thought to increase PA. There appear to be no reviews which investigate the effect of WPAM in cardiac populations. We firstly aimed to systematically review randomised controlled trials within the cardiac population that investigated the effect WPAM had through the maintenance phase of CR. We specifically examined the effect on cardiorespiratory fitness (CRF), amount and intensity of daily PA, and sedentary time. Secondly, we aimed to collate outcome measures reported, reasons for drop out, adverse events, and psychological impact from utilising a WPAM.MethodsA systematic search (up to January 2019) of relevant databases was completed, followed by a narrative synthesis, meta-analysis and qualitative analysis.ResultsNine studies involving 1,352 participants were included. CRF was improved to a greater extent in participants using WPAM with exercise prescription or advice compared with controls (MD 1.65mL/kg/min;95% confidence interval [CI; 0.64-2.66]; p=0.001; I-2=0%). There was no significant between group difference in six-minute walk test distance. In 70% of studies, step count was greater in participants using a WPAM with exercise prescription or advice, however the overall effect was not significant (SMD 0.45;95% [CI; -0.17-1.07] p=0.15; I-2=81%). A sensitivity analysis resulted in significantly greater step counts in participants using a WPAM with exercise prescription or advice and reduced the heterogeneity from 81 to 0% (SMD 0.78;95% [CI;0.54-1.02];

ClgR regulation of chaperone and protease systems is essential for Mycobacterium tuberculosis parasitism of the macrophage

Chaperone and protease systems play essential roles in cellular homeostasis and have vital functions in controlling the abundance of specific cellular proteins involved in processes such as transcription, replication, metabolism and virulence. Bacteria have evolved accurate regulatory systems to control the expression and function of chaperones and potentially destructive proteases. Here, we have used a combination of transcriptomics, proteomics and targeted mutagenesis to reveal that the clp gene regulator (ClgR) of Mycobacterium tuberculosis activates the transcription of at least ten genes, including four that encode protease systems (ClpP1/C, ClpP2/C, PtrB and HtrA-like protease Rv1043c) and three that encode chaperones (Acr2, ClpB and the chaperonin Rv3269). Thus, M. tuberculosis ClgR controls a larger network of protein homeostatic and regulatory systems than ClgR in any other bacterium studied to date. We demonstrate that ClgR-regulated transcriptional activation of these systems is essential for M. tuberculosis to replicate in macrophages. Furthermore, we observe that this defect is manifest early in infection, as M. tuberculosis lacking ClgR is deficient in the ability to control phagosome pH 1 h post-phagocytosis

Change and Persistence, Proceedings of the International Conference, Tunis, 12-13 November 2013

This publication is based on the proceedings of an international conference entitled ‘Arab Revolutions and Beyond: Change and Persistence’, which was held in the framework of a multilateral project called ‘Challenges and Transformations in the Wake of the Arab Spring’ (2012-2014). The project is funded by the DAAD (German Academic Exchange Service) and based upon the longstanding partnership between Cairo University in Egypt and Freie Universität Berlin in Germany, specifically between the EuroMed Study Program at the Faculty of Economics and Political Sciences (FEPS) and the Centre for Middle Eastern and North African Politics at Otto-Suhr-Institute, Department for Political and Social Sciences. Dieser Sammelband ist ein Ergebnis der internationalen Tunis-Konferenz "Arab Revolutions and Beyond: Change and Persistence", die im Rahmen des multinationalen DAAD-Projekts "Challenges and Transformations in the Wake of the Arab Spring" im November 2013 stattfand. Neben Kolleg_innen der Universität Kairo, mit der bereits eine langjährige Partnerschaft besteht, sind auch Nachwuchsforscher_innen aus Tunesien, Libyen, Jordanien und weiteren Arabischen Staaten beteiligt. Das Projekt stellt sich den Herausforderungen, welche sich durch die politischen und sozialen Umbrüche in der Region für die akademische Bildung, v.a. in den Sozialwissenschaften ergeben haben. Hieraus soll ein produktiver Dialog über theoretische, methodische und thematische Felder der Sozialwissenschaften eröffnet werden, um die Strukturen von Forschung und Lehre dauerhaft zu verbessern.This publication is based on the proceedings of an international conference entitled ‘Arab Revolutions and Beyond: Change and Persistence’, which was held in the framework of a multilateral project called ‘Challenges and Transformations in the Wake of the Arab Spring’ (2012-2014). The project is funded by the DAAD (German Academic Exchange Service) and based upon the longstanding partnership between Cairo University in Egypt and Freie Universität Berlin in Germany, specifically between the EuroMed Study Program at the Faculty of Economics and Political Sciences (FEPS) and the Centre for Middle Eastern and North African Politics at Otto-Suhr-Institute, Department for Political and Social Sciences. The project addresses the challenges of current political and social transformations and their ramifications for higher education and the social sciences in Egypt and the region. The overarching objective of the project is to enter a productive dialogue on theories, methodologies and topics in social science research among Arab and German researchers. At the same time, we aim to improve teaching and research structures in the social sciences in a sustainable and efficient way. This will build students’ and teachers’ capacities on both shores of the Mediterranean and at the same time strengthen institutional efforts to promote the role of social sciences in the current transformations

Mechanical Ventilation in the Trauma Patient

In this chapter, we discuss the unique ventilatory strategies of the trauma patient. Injuries can be direct to the lung resulting from the trauma or indirect because of other injury to the body. We will discuss the airway and ventilation management and concerns in a patient with chest trauma, abdominal trauma, head trauma, orthopedic, and burn injury. The chapter will explain lung-protective strategies as well as innovative ventilation management techniques including extracorporeal membrane oxygenation

Former of Turn Trajectory of Sliding Valve Shaft of Gas Line

Former of turn trajectory of sliding valve shaft of gas line, that allows to provide desired motion trajectory of sliding valve and its full closing, is considered in that paper. Imitation model of that former, research results, which allow to detect influence of gain factor and time constant of position controller on value of speed error, that has impact on delay of output coordinate from setting, and that results to delay of sliding valve motion process to setting position point, are shown

Identification of conditionally essential genes for Streptococcus suis infection in pigs

Streptococcus suis is a Gram-positive bacterium and zoonotic pathogen that causes meningitis and sepsis in pigs and humans. The aim of this study was to identify genes required for S. suis infection. We created Tn-Seq libraries in a virulent S. suis strain 10, which was used to inoculate pigs in an intrathecal experimental infection. Comparative analysis of the relative abundance of mutants recovered from different sites of infection (blood, cerebrospinal fluid, and meninges of the brain) identified 361 conditionally essential genes, i.e. required for infection, which is about 18% of the genome. The conditionally essential genes were primarily involved in metabolic and transport processes, regulation, ribosomal structure and biogenesis, transcription, and cell wall membrane and envelope biogenesis, stress defenses, and immune evasion. Directed mutants were created in a set of 10 genes of different genetic ontologies and their role was determined in ex vivo models. Mutants showed different levels of sensitivity to survival in whole blood, serum, cerebrospinal fluid, thermic shock, and stress conditions, as compared to the wild type. Additionally, the role of three selected mutants was validated in co-infection experiments in which pigs were infected with both wild type and isogenic mutant strains. The genetic determinants of infection identified in this work contribute to novel insights in S. suis pathogenesis and could serve as targets for novel vaccines or antimicrobial drugs

Gene expression profiling of mesenteric lymph nodes from sheep with natural scrapie

Background: Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system. Although prions multiply/accumulate in the lymph nodes without any detectable pathology, transcriptional changes in this tissue may reflect biological processes that contribute to the molecular pathogenesis of prion diseases. Little is known about the molecular processes that occur in the lymphoreticular system in early and late stages of prion disease. We performed a microarray-based study to identify genes that are differentially expressed at different disease stages in the mesenteric lymph node of sheep naturally infected with scrapie. Oligo DNA microarrays were used to identify gene-expression profiles in the early/middle (preclinical) and late (clinical) stages of the disease. Results: In the clinical stage of the disease, we detected 105 genes that were differentially expressed (=2-fold change in expression). Of these, 43 were upregulated and 62 downregulated as compared with age-matched negative controls. Fewer genes (50) were differentially expressed in the preclinical stage of the disease. Gene Ontology enrichment analysis revealed that the differentially expressed genes were largely associated with the following terms: glycoprotein, extracellular region, disulfide bond, cell cycle and extracellular matrix. Moreover, some of the annotated genes could be grouped into 3 specific signaling pathways: focal adhesion, PPAR signaling and ECM-receptor interaction. We discuss the relationship between the observed gene expression profiles and PrPSc deposition and the potential involvement in the pathogenesis of scrapie of 7 specific differentially expressed genes whose expression levels were confirmed by real time-PCR. Conclusions: The present findings identify new genes that may be involved in the pathogenesis of natural scrapie infection in the lymphoreticular system, and confirm previous reports describing scrapie-induced alterations in the expression of genes involved in protein misfolding, angiogenesis and the oxidative stress response. Further studies will be necessary to determine the role of these genes in prion replication, dissemination and in the response of the organism to this disease