Sneutrino as Lightest Supersymmetric Particle in B3 mSUGRA Models and Signals at the LHC

We consider B3 mSUGRA models where we have one lepton number violating LQD operator at the GUT scale. This can alter the supersymmetric mass spectrum leading to a sneutrino as the lightest supersymmetric particle in a large region of parameter space. We take into account the restrictions from neutrino masses, the muon anomalous magnetic moment, b -> s gamma and other precision measurements. We furthermore investigate existing restrictions from direct searches at LEP, the Tevatron and the CERN p\bar p collider. We then give examples for characteristic signatures at the LHC.Comment: 22 pages, 11 figure

Stau as the Lightest Supersymmetric Particle in R-Parity Violating SUSY Models: Discovery Potential with Early LHC Data

We investigate the discovery potential of the LHC experiments for R-parity violating supersymmetric models with a stau as the lightest supersymmetric particle (LSP) in the framework of minimal supergravity. We classify the final states according to their phenomenology for different R-parity violating decays of the LSP. We then develop event selection cuts for a specific benchmark scenario with promising signatures for the first beyond the Standard Model discoveries at the LHC. For the first time in this model, we perform a detailed signal over background analysis. We use fast detector simulations to estimate the discovery significance taking the most important Standard Model backgrounds into account. Assuming an integrated luminosity of 1 inverse femtobarn at a center-of-mass energy of 7 TeV, we perform scans in the parameter space around the benchmark scenario we consider. We then study the feasibility to estimate the mass of the stau-LSP. We briefly discuss difficulties, which arise in the identification of hadronic tau decays due to small tau momenta and large particle multiplicities in our scenarios.Comment: 26 pages, 18 figures, LaTeX; minor changes, final version published in PR

Light Stop Searches at the LHC in Events with two b-Jets and Missing Energy

We propose a new method to discover light top squarks (stops) in the co-annihilation region at the Large Hadron Collider (LHC). The bino-like neutralino is the lightest supersymmetric particle (LSP) and the lighter stop is the next-to-LSP. Such scenarios can be consistent with electroweak baryogenesis and also with dark matter constraints. We consider the production of two stops in association with two b-quarks, including pure QCD as well as mixed electroweak-QCD contributions. The stops decay into a charm quark and the LSP. For a higgsino-like light chargino the electroweak contributions can exceed the pure QCD prediction. We show the size of the electroweak contributions as a function of the stop mass and present the LHC discovery reach in the stop-neutralino mass plane.Comment: 12 pages, 10 figure

Sneutrino LSPs in R-parity violating minimal supergravity models

We consider the minimal supergravity model (mSUGRA) with one additional R-parity violating operator at the GUT scale. The superparticles mass spectra at the weak scale are generally altered due to the presence of the R-parity violating coupling in the renormalization group equations. We show that a lepton number violating coupling at the GUT scale can lead to a sneutrino as the lightest supersymmetric particle (LSP) in a large region of parameter space consistent with the muon anomalous magnetic moment and other precision measurements. We also give characteristic collider signatures at the LHC.Comment: 3 pages, 3 figures, to appear in the proceedings of SUSY08, Seoul, Kore

Supersymmetric NLO QCD Corrections to Resonant Slepton Production and Signals at the Tevatron and the LHC

We compute the total cross section and the transverse momentum distribution for single charged slepton and sneutrino production at hadronic colliders including NLO supersymmetric and non-supersymmetric QCD corrections. The supersymmetric QCD corrections can be substantial. We also resum the gluon transverse momentum distribution and compare our results with two Monte Carlo generators. We compute branching ratios of the supersymmetric decays of the slepton and determine event rates for the like-sign dimuon final state at the Tevatron and at the LHC.Comment: 14 pages, LaTeX, 8 figures, uses REVTex

T. brucei cathepsin-L increases arrhythmogenic sarcoplasmic reticulum-mediated calcium release in rat cardiomyocytes

Aims: African trypanosomiasis, caused by Trypanosoma brucei species, leads to both neurological and cardiac dysfunction and can be fatal if untreated. While the neurological-related pathogenesis is well studied, the cardiac pathogenesis remains unknown. The current study exposed isolated ventricular cardiomyocytes and adult rat hearts to T. brucei to test whether trypanosomes can alter cardiac function independent of a systemic inflammatory/immune response. Methods and results: Using confocal imaging, T. brucei and T. brucei culture media (supernatant) caused an increased frequency of arrhythmogenic spontaneous diastolic sarcoplasmic reticulum (SR)-mediated Ca2+ release (Ca2+ waves) in isolated adult rat ventricular cardiomyocytes. Studies utilising inhibitors, recombinant protein and RNAi all demonstrated that this altered SR function was due to T. brucei cathepsin-L (TbCatL). Separate experiments revealed that TbCatL induced a 10–15% increase of SERCA activity but reduced SR Ca2+ content, suggesting a concomitant increased SR-mediated Ca2+ leak. This conclusion was supported by data demonstrating that TbCatL increased Ca2+ wave frequency. These effects were abolished by autocamtide-2-related inhibitory peptide, highlighting a role for CaMKII in the TbCatL action on SR function. Isolated Langendorff perfused whole heart experiments confirmed that supernatant caused an increased number of arrhythmic events. Conclusion: These data demonstrate for the first time that African trypanosomes alter cardiac function independent of a systemic immune response, via a mechanism involving extracellular cathepsin-L-mediated changes in SR function

Research Proposal for an Experiment to Search for the Decay {\mu} -> eee

We propose an experiment (Mu3e) to search for the lepton flavour violating decay mu+ -> e+e-e+. We aim for an ultimate sensitivity of one in 10^16 mu-decays, four orders of magnitude better than previous searches. This sensitivity is made possible by exploiting modern silicon pixel detectors providing high spatial resolution and hodoscopes using scintillating fibres and tiles providing precise timing information at high particle rates.Comment: Research proposal submitted to the Paul Scherrer Institute Research Committee for Particle Physics at the Ring Cyclotron, 104 page