Sensors data collection framework using mobile identification with secure data sharing model

Sensors are the modules or electronic devices that are used to measure and get environmental events and send the captured data to other devices, usually computer processors allocated on the cloud. One of the most recent challenges is to protect and save the privacy issues of those sensors data on the cloud sharing. In this paper, sensors data collection framework is proposed using mobile identification and proxy re-encryption model for data sharing. The proposed framework includes: identity broker server, sensors managing and monitoring applications, messages queuing sever and data repository server. Finally, the experimental results show that the proposed proxy re-encryption model can work in real time

The Toxicological Impacts of the Fusarium Mycotoxin, Deoxynivalenol, in Poultry Flocks with Special Reference to Immunotoxicity

Deoxynivalenol (DON) is a common Fusarium toxin in poultry feed. Chickens are more resistant to the adverse impacts of deoxynivalenol (DON) compared to other species. In general, the acute form of DON mycotoxicosis rarely occurs in poultry flocks under normal conditions. However, if diets contain low levels of DON (less than 5 mg DON/kg diet), lower productivity, impaired immunity and higher susceptibility to infectious diseases can occur. The molecular mechanism of action of DON has not been completely understood. A significant influence of DON in chickens is the impairment of immunological functions. It was known that low doses of DON elevated the serum IgA levels and affected both cell-mediated and humoral immunity in animals. DON is shown to suppress the antibody response to infectious bronchitis vaccine (IBV) and to Newcastle disease virus (NDV) in broilers (10 mg DON/kg feed) and laying hens (3.5 to 14 mg of DON/kg feed), respectively. Moreover, DON (10 mg DON/kg feed) decreased tumor necrosis factor alpha (TNF-α) in the plasma of broilers. DON can severely affect the immune system and, due to its negative impact on performance and productivity, can eventually result in high economic losses to poultry producers. The present review highlights the impacts of DON intoxication on cell mediated immunity, humoral immunity, gut immunity, immune organs and pro-inflammatory cytokines in chickens

Novel Open Source Python Neutrosophic Package

Neutrosophic sets has gained wide popularity and acceptance in both academia and industry. Different fields have successfully adopted and utilized neutrosophic sets. However, there is no open-source implementation that provides the basic neutrosophic concepts. Open-source is a global movement that enables developers to share their source-code, as researchers do share their research ideas and results. Presented Open-source python neutrosophic package is the first of its kind. It utilizes object oriented concepts. It is based on one of the most popular multiparadigm programming languages that is widely used in different academic and industry fields and activities; namely python. Presented package tends to dissolve the barriers and enable both researchers and developers to adopt neutrosophic sets and theory in research and applications. In this paper, the first Open-source, Object-Oriented, Python based Neutrosophic package is presented. This paper intensively scanned neutrosophic sets research attempting to reach the most widely accepted neutrosophic proofs, and then transforming them into source-code. Presented package implements most of the basic neutrosophic concepts. Presented neutrosophic package presents four different classes: Single Valued Neutrosophic Number, Single Valued Neutrosophic Sets, Interval Valued Neutrosophic Number, and Interval Valued Neutrosophic Sets

The economic efficiency analysis of some rice mills in Egypt by using DEA and SFA

The main aim of this paper is measuring the economic efficiency of the rice mills public sector in Egypt and comparing the best company according to the economic efficiency. This aim is achieved by estimating the economic efficiency using Data Envelopment Analysis (DEA) and Stochastic Frontier Approach (SFA). This paper is based on some unpublished secondary data which is obtained from the rice mills of the public sector in Egypt from 2003 to 2014. The paper focuses on five main companies which are Domyat and Belqas, Dakahlia, Gharbia, Behiera and Kafer El-Sheikh. The most important results are that according to the dependent variable production (Y1), there is economic efficiency in rice mills Domyat and Belqas and Kafer El-Sheikh score by 1. While in rice mills Gharbia, Dakahlia and Behiera score by 40%, 49.3%, 38% (efficiency = 0.401, 0.507, and 0.622) respectively. While according to the dependent variable sales (Y2), there is economic efficiency in rice mills Domyat and Belqas, Gharbia, Dakahlia and Kafer El-Sheikh score by 1. While Behiera rice mills has economic inefficiency score by 21% (efficiency = 0.791)

The economic efficiency analysis of some rice mills in Egypt by using DEA and SFA

The main aim of this paper is measuring the economic efficiency of the rice mills public sector in Egypt and comparing the best company according to the economic efficiency. This aim is achieved by estimating the economic efficiency using Data Envelopment Analysis (DEA) and Stochastic Frontier Approach (SFA). This paper is based on some unpublished secondary data which is obtained from the rice mills of the public sector in Egypt from 2003 to 2014. The paper focuses on five main companies which are Domyat and Belqas, Dakahlia, Gharbia, Behiera and Kafer El-Sheikh. The most important results are that according to the dependent variable production (Y1), there is economic efficiency in rice mills Domyat and Belqas and Kafer El-Sheikh score by 1. While in rice mills Gharbia, Dakahlia and Behiera score by 40%, 49.3%, 38% (efficiency = 0.401, 0.507, and 0.622) respectively. While according to the dependent variable sales (Y2), there is economic efficiency in rice mills Domyat and Belqas, Gharbia, Dakahlia and Kafer El-Sheikh score by 1. While Behiera rice mills has economic inefficiency score by 21% (efficiency = 0.791)

GAS CHROMATOGRAPHY-MASS SPECTROMETRY ANALYSIS AND ANTIOXIDANT ACTIVITY OF PUNICA GRANATUM L. PEELS AND ITS ROLE AS IMMUNOSTIMULANT AGAINST SCHISTOSOMA MANSONI INFECTION IN BIOMPHALARIA ALEXANDRINA

Objective: To evaluate the antioxidant activity and chemical composition of Punica granatum L. and test it as immunostimulants against Schistosoma mansoni infection to Biomphalaria alexandrina snails.Methods: Antioxidant activity was evaluated by measuring the free radical scavenging activity of the 90% defatted methanol extract (90% DM) of P. granatum peels and its sub-derived fractions was evaluated via 2,2'-diphenyl-1-picrylhydrazyl and its chemical constituents were identified via gas chromatography-mass spectrometry (GC-MS) analysis. B. alexandrina snails were exposed to pomegranate extracts (PEs) for 1 month before their challenging with S. mansoni miracidia. Infection rates, immunological and histological parameters were, then, evaluated in PE-exposed snails and compared to controls.Results: The antioxidants activities of PE, expressed as scavenging concentration at 50%, were in the following order; 90% DM (12.45) ˃n-butanol(15.59) ˃ethyl acetate (21.36) ˃water (49.16) µg/ml, compared to 7.50 µg/ml for ascorbic acid. The infection rates of PE-exposed snails were 20%,50%, 60%, 70%, and 80%, respectively, for 90% DM, n-butanol, ethyl acetate, water, and dichloromethane extracts compared to 95% in control snails. The number of amoebocytes showed a significant increase, clear differentiation, and size increment in exposed snails compared to controls. Moreover, hermaphrodite glands histology shows a full maturity in the formation of reproductive cells in PE-exposed snails. The GC-MS analysis of the 90% DM extract revealed the presence of 36 compounds representing 93.1% of the total composition. Piperidin-4-ol, 1,3-dimethyl-2,4,6-triphenyl (19.87%), and 6,11-dihydroxy-5,12 naphthacenequinone-1-carboxylic acid (7.80%) were the major components.Conclusion: The identified compounds in 90% DM extract of P. granatum may be responsible for the high antioxidant activity of the fruit and it may account for its immunostimulatory effect against S. mansoni infection in B. alexandrina.Keywords: Punica granatum L., Antioxidant activity, Biomphalaria alexandrina, Schistosoma mansoni, Infection rate, Gas chromatography-mass spectrometry

Investigation of Solubility Enhancement Approaches of Ticagrelor

ABSTRACT                    Ticagrelor is an orally administered antiplatelet medicine, direct-acting P2Y12-receptor antagonist. Ticagrelor binds reversibly and noncompetitively to the P2Y12 receptor at a site distinct from that of the endogenous agonist adenosine diphosphate (ADP). Inhibition of platelet aggregation stimulated by ADP is a commonly used pharmacodynamic parameter for P2Y12-receptor antagonists.                   Ticagrelor is a crystalline powder with an aqueous solubility of approximately 10?g/mL at room temperature. Ticagrelor exhibits no pKa value within the physiological range. Ticagrelor does not exhibit pH-dependent solubility and is defined as ‘low solubility low permeability’ under the Biopharmaceutics Classification System (Class IV). The mean absolute bioavailability of ticagrelor in healthy volunteers is 36 %                    Nanoparticles preparation and complexation is one of the recently used approaches to enhance the solubility of drugs. The aim of the present work was to improve the solubility and dissolution of ticagrelor by preparing nanoparticles and cyclodextrin inclusion complex of ticagrelor and then incorporated in to tablet dosage form. Fifteen formulas of nanoparticles were prepared by antisolvent precipitation method (solvent displacement method) utilizing one of the three polymers (PVP, Poloxamer, and HPMC) at three different drugs: polymer and solvent: anti-solvent ratios and nine formulas of cyclodextrin inclusion complex with HP?CD  by three preparation methods, physical trituration, kneading and solvent evaporation, which increase the solubility and dissolution rate of ticagrelor via formation of inclusion complex with HP?CD.               The prepared formulas were characterized regarding the saturated solubility, polydispersity index, particle size by nano laser particle size analyzer, % yield, entrapment efficiency, and flowability, FTIR, DSC, and SEM. The selected formulas were prepared as tablets.              The prepared tablets were evaluated for drug content, weight variation, hardness, and friability. In vitro dissolution data of the prepared tablets were analyzed using similarity factor (f2) and dissolution efficiency (DE).              Among all the prepared nanoparticles formulas, formula (F12) which contain HPMC as a polymer at polymer: drug ratio of (1:1) and solvent: antisolvent ratio of (1:1) was considered as the optimum formula which shows good evaluation parameters in addition to the increment in the solubility to about 9 times than that of the pure drug. The nanoparticle of the selected formula (F12) incorporated tablets showed an acceptable tablet properties in addition to a considerable increase in the dissolution efficiency to (DE=92 % and 88 % in PH 1.2 and PH 6.8 respectively) in comparison to that of the marketed tablet (DE=89% and 85% in PH 1.2 and PH 6.8 respectively).  Moreover, the analysis by DSC and SEM of the nanoparticles of the selected formula (F12) indicate a reduction in the crystallinity and amorphization of the drug. It can be concluded that the selected formula is a promising formula for the preparation of ticagrelor nanoparticles the incorporation in a tablet dosage form.           Regarding ticagrelor inclusion complex with HP?CD Solvent evaporation method was the most effective method regarding ticagrelor solubilization and optimum formula of inclusion complex (F23) show increment in saturated solubility about ten times that of pure drug.           The ticagrelor inclusion complex of the selected formula (F23) incorporated tablets showed an acceptable tablet properties in addition to a considerable increase in the dissolution efficiency to (DE=92 % and 90 % in PH 1.2 and PH 6.8 respectively) in comparison to that of the marketed tablet (DE=89% and 85% in PH 1.2 and PH 6.8 respectively).