Lunar penetrometer Patent

Development and characteristics of pentrometer for measuring physical properties of lunar surfac

The Physics Inside Topological Quantum Field Theories

We show that the equations of motion defined over a specific field space are realizable as operator conditions in the physical sector of a generalized Floer theory defined over that field space. The ghosts associated with such a construction are found not to be dynamical. This construction is applied to gravity on a four dimensional manifold, $M$; whereupon, we obtain Einstein's equations via surgery, along $M$, in a five-dimensional topological quantum field theory.Comment: LaTeX, 7 page

Grain growth in the envelopes and disks of Class I protostars

We present new 3 mm ATCA data of two Class I Young Stellar Objects in the Ophiucus star forming region: Elias29 and WL12. For our analysis we compare them with archival 1.1 mm SMA data. In the (u,v) plane the two sources present a similar behavior: a nearly constant non-zero emission at long baselines, which suggests the presence of an unresolved component and an increase of the fluxes at short baselines, related to the presence of an extended envelope. Our data analysis leads to unusually low values of the spectral index $\alpha_{\rm 1.1-3mm}$, which may indicate that mm-sized dust grains have already formed both in the envelopes and in the disk-like structures at such early stages. To explore the possible scenarios for the interpretation of the sources we perform a radiative transfer modeling using a Monte Carlo code, in order to take into account possible deviations from the Rayleigh-Jeans and optically thin regimes. Comparison between the model outputs and the observations indicates that dust grains may form aggregates up to millimeter size already in the inner regions of the envelopes of Class I YSOs. Moreover, we conclude that the embedded disk-like structures in our two Class Is are probably very compact, in particular in the case of WL12, with outer radii down to tens of AU.Comment: 12 pages, 8 figures, Accepted for publication in A&

Topology, Quantum Gravity and Particle Physics

It is argued that quantum gravity has an interpretation as a topological field theory provided a certain constraint from the path intergral measure is respected. The constraint forces us to couple gauge and matter fields to gravity for space - time dimensions different from 3. We then discuss possible models which may be relevant to our universe.Comment: 18 pages, LaTeX. Replaced version corrects typos and has additional reference

Is Lactate an Oncometabolite? Evidence Supporting a Role for Lactate in the Regulation of Transcriptional Activity of Cancer-Related Genes in MCF7 Breast Cancer Cells.

Lactate is a ubiquitous molecule in cancer. In this exploratory study, our aim was to test the hypothesis that lactate could function as an oncometabolite by evaluating whether lactate exposure modifies the expression of oncogenes, or genes encoding transcription factors, cell division, and cell proliferation in MCF7 cells, a human breast cancer cell line. Gene transcription was compared between MCF7 cells incubated in (a) glucose/glutamine-free media (control), (b) glucose-containing media to stimulate endogenous lactate production (replicating some of the original Warburg studies), and (c) glucose-containing media supplemented with L-lactate (10 and 20 mM). We found that both endogenous, glucose-derived lactate and exogenous, lactate supplementation significantly affected the transcription of key oncogenes (MYC, RAS, and PI3KCA), transcription factors (HIF1A and E2F1), tumor suppressors (BRCA1, BRCA2) as well as cell cycle and proliferation genes involved in breast cancer (AKT1, ATM, CCND1, CDK4, CDKN1A, CDK2B) (0.001 < p < 0.05 for all genes). Our findings support the hypothesis that lactate acts as an oncometabolite in MCF7 cells. Further research is necessary on other cell lines and biopsy cultures to show generality of the findings and reveal the mechanisms by which dysregulated lactate metabolism could act as an oncometabolite in carcinogenesis

Phenomenology of Dirac Neutrinogenesis in Split Supersymmetry

In Split Supersymmetry scenarios the possibility of having a very heavy gravitino opens the door to alleviate or completely solve the worrisome "gravitino problem'' in the context of supersymmetric baryogenesis models. Here we assume that the gravitino may indeed be heavy and that Majorana masses for neutrinos are forbidden as well as direct Higgs Yukawa couplings between left and right handed neutrinos. We investigate the viability of the mechansim known as Dirac leptogenesis (or neutrinogenesis), both in solving the baryogenesis puzzle and explaining the observed neutrino sector phenomenology. To successfully address these issues, the scenario requires the introduction of at least two new heavy fields. If a hierarchy among these new fields is introduced, and some reasonable stipulations are made on the couplings that appear in the superpotential, it becomes a generic feature to obtain the observed large lepton mixing angles. We show that in this case, it is possible simultaneously to obtain both the correct neutrino phenomenology and enough baryon number, making thermal Dirac neutrinogenesis viable. However, due to cosmological constraints, its ability to satisfy these constraints depends nontrivially on model parameters of the overall theory, particularly the gravitino mass. Split supersymmetry with m_{3/2} between 10^{5} and 10^{10} GeV emerges as a "natural habitat" for thermal Dirac neutrinogenesis.Comment: 37 pages, 8 figure

Dynamical Dark Matter: II. An Explicit Model

In a recent paper (arXiv:1106.4546), we introduced "dynamical dark matter," a new framework for dark-matter physics, and outlined its underlying theoretical principles and phenomenological possibilities. Unlike most traditional approaches to the dark-matter problem which hypothesize the existence of one or more stable dark-matter particles, our dynamical dark-matter framework is characterized by the fact that the requirement of stability is replaced by a delicate balancing between cosmological abundances and lifetimes across a vast ensemble of individual dark-matter components. This setup therefore collectively produces a time-varying cosmological dark-matter abundance, and the different dark-matter components can interact and decay throughout the current epoch. While the goal of our previous paper was to introduce the broad theoretical aspects of this framework, the purpose of the current paper is to provide an explicit model of dynamical dark matter and demonstrate that this model satisfies all collider, astrophysical, and cosmological constraints. The results of this paper therefore constitute an "existence proof" of the phenomenological viability of our overall dynamical dark-matter framework, and demonstrate that dynamical dark matter is indeed a viable alternative to the traditional paradigm of dark-matter physics. Dynamical dark matter must therefore be considered alongside other approaches to the dark-matter problem, particularly in scenarios involving large extra dimensions or string theory in which there exist large numbers of particles which are neutral under Standard-Model symmetries.Comment: 45 pages, LaTeX, 10 figures. Replaced to match published versio

Lepton Flavor Violation and Supersymmetric Dirac Leptogenesis

Dirac leptogenesis (or Dirac neutrinogenesis), in which neutrinos are purely Dirac particles, is an interesting alternative to the standard leptogenesis scenario. In its supersymmetric version, the modified form of the superpotential required for successful baryogenesis contributes new, generically non-flavor-diagonal terms to the slepton and sneutrino mass matrices. In this work, we examine how current experimental bounds on flavor-changing effects in the lepton sector (and particularly the bound on Mu -> e Gamma) constrain Dirac leptogenesis and we find that it is capable of succeeding with superpartner masses as low as 100 GeV. For such light scalars and electroweakinos, upcoming experiments such as MEG are generically expected to observe signals of lepton flavor violation.Comment: 15 pages, 4 figures, corrected parametric dependance on leading LFV term, figure 2 and discussion modified accordingly, conclusions unchange