3,358 research outputs found
Young people who display harmful sexual behaviors and their families : a qualitative systematic review of their experiences of professional interventions.
It is estimated that 30–50% of all childhood sexual abuse involves other young people as perpetrators. The treatment of harmful sexual behavior (HSB) in young people has evolved from interventions developed for use with adult perpetrators of sexual offenses. Increasingly, these approaches were not seen as appropriate for use with young people. The purpose of this qualitative systematic review was to establish what intervention components are viewed as acceptable or useful by young people and their families in order to inform the development of interventions for young people with HSB. We conducted searches across 14 electronic databases as well as contacting experts to identify relevant studies. Thirteen qualitative studies were included in the analysis, reporting findings from intervention studies from the United Kingdom, United States, New Zealand, Australia, and Ireland. Thematic analysis was used to combine findings from the studies of young people and parent/carers views. Five key themes were identified as critical components of successful interventions for young people with HSB. These included the key role of the relationship between the young person and practitioner, the significance of the role of parents and carers, the importance of considering the wider context in which the abuse has occurred, the role of disclosure in interventions, and the need to equip young people with skills as well as knowledge. The evidence was limited by the small number of studies that were mainly from the perspectives of adolescent males
Sub-Nyquist Field Trial Using Time Frequency Packed DP-QPSK Super-Channel Within Fixed ITU-T Grid
Sub-Nyquist time frequency packing technique was demonstrated for the first
time in a super channel field trial transmission over long-haul distances. The
technique allows a limited spectral occupancy even with low order modulation
formats. The transmission was successfully performed on a deployed Australian
link between Sydney and Melbourne which included 995 km of uncompensated SMF
with coexistent traffic. 40 and 100 Gb/s co-propagating channels were
transmitted together with the super-channel in a 50 GHz ITU-T grid without
additional penalty. The super-channel consisted of eight sub-channels with
low-level modulation format, i.e. DP-QPSK, guaranteeing better OSNR robustness
and reduced complexity with respect to higher order formats. At the receiver
side, coherent detection was used together with iterative maximum-a-posteriori
(MAP) detection and decoding. A 975 Gb/s DP-QPSK super-channel was successfully
transmitted between Sydney and Melbourne within four 50GHz WSS channels (200
GHz). A maximum potential SE of 5.58 bit/s/Hz was achieved with an OSNR=15.8
dB, comparable to the OSNR of the installed 100 Gb/s channels. The system
reliability was proven through long term measurements. In addition, by closing
the link in a loop back configuration, a potential SE*d product of 9254
bit/s/Hz*km was achieved
Is overweight and obesity in 9–10-year-old children in Liverpool
Objectives: To determine whether weight problems in children (overweight, obesity and overweight or obesity) were related to deprivation indices when attributed only according to electoral ward of the school attended. To determine whether children
with weight problems were more likely to be found in some wards rather than others, and to compare the distribution for boys and girls.
Design: Retrospective, cross-sectional, observational study.
Setting: One hundred and six primary schools from all parts of Liverpool city.
Subjects: Five cohorts of 9–10-year-old children between 1998 and 2003.
Main outcome measures: Body mass index (BMI) for each child to estimate proportions overweight, obese and overweight or obese according to international criteria.
Results: Between January 1998 and March 2003, the heights and weights of 7902 boys and 7514 girls were measured and BMI calculated. The prevalence of boys and girls categorised as overweight or obese was very high (1620, 20.6% and 1909, 25.7%,
respectively). Prevalence was not related to deprivation and varied between wards only for the girls; some wards had very different prevalence rates for boys and girls (Picton: 59 boys, 23.4%; 106 girls, 36.6%). The most deprived ward did not have a
remarkable prevalence of overweight or obesity (Speke: 32 boys, 15.3%; 40 girls, 19.8%).
Conclusions: Obesity is a major problem and requires urgent action but targeting intervention on the basis of administrative areas may be very wasteful. Different factors seem to lead to obesity in boys and girls, and attention should be paid to the
role of the physical environment
Identification of Nuclear and Cytoplasmic mRNA Targets for the Shuttling Protein SF2/ASF
The serine and arginine-rich protein family (SR proteins) are highly conserved regulators of pre-mRNA splicing. SF2/ASF, a prototype member of the SR protein family, is a multifunctional RNA binding protein with roles in pre-mRNA splicing, mRNA export and mRNA translation. These observations suggest the intriguing hypothesis that SF2/ASF may couple splicing and translation of specific mRNA targets in vivo. Unfortunately the paucity of endogenous mRNA targets for SF2/ASF has hindered testing of this hypothesis. Here, we identify endogenous mRNAs directly cross-linked to SF2/ASF in different subcellular compartments. Cross-Linking Immunoprecipitation (CLIP) captures the in situ specificity of protein-RNA interaction and allows for the simultaneous identification of endogenous RNA targets as well as the locations of binding sites within the RNA transcript. Using the CLIP method we identified 326 binding sites for SF2/ASF in RNA transcripts from 180 protein coding genes. A purine-rich consensus motif was identified in binding sites located within exon sequences but not introns. Furthermore, 72 binding sites were occupied by SF2/ASF in different sub-cellular fractions suggesting that these binding sites may influence the splicing or translational control of endogenous mRNA targets. We demonstrate that ectopic expression of SF2/ASF regulates the splicing and polysome association of transcripts derived from the SFRS1, PABC1, NETO2 and ENSA genes. Taken together the data presented here indicate that SF2/ASF has the capacity to co-regulate the nuclear and cytoplasmic processing of specific mRNAs and provide further evidence that the nuclear history of an mRNA ma
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Klinefelters Syndrome: Change in T-Scores with Testosterone, Bisphosphonate, and Vitamin D Treatment over 6 Years
Background: Klinefelter's syndrome (KS) is characterized by extra X chromosomes and features of primary hypogonadism including osteopenia and osteoporosis. Testosterone therapy (TTh) is widely used to treat men with KS and low serum testosterone/hypogonadal symptoms, though studies on its efficacy in improving bone density show varied outcomes. Materials and Methods: We studied the effects of TTh, bisphosphonates, and vitamin D/calcium in 38 men with KS and low testosterone, hypogonadal symptoms, and T-scores consistent with osteoporosis. Our aim was to investigate at the end of follow-up (median: 87 months, range: 27-147 months), associations between age, baseline total testosterone, and T-scores, and change in T-scores after treatment. Results: At final assessment, all men had T-score values outside the osteoporotic range (-1.1 standard deviation [SD],-1.8 SD). Baseline age but not median baseline testosterone appeared associated with change in T-score and T-score at final assessment. All men had dual-energy X-ray absorptiometry every 6 months and demonstrated continued improvement in T-scores after 3 months and up to 72 months. Baseline age and T-scores (stratified by median) were associated with change in T-score at final assessment. Compared with men ≥51 years, those aged <51 years showed significantly greater improvement in T-scores between 6 and 30 months. Men with worse T-score values (<3.7 SD) showed significantly greater improvement at every time point up to 36 months. Our results indicate that TTh, bisphosphonates, and vitamin D/calcium improve osteoporosis although there is a need to better understand the effects of the individual therapies, age, and baseline T-score on treatment efficacy
Superstring partition functions in the doubled formalism
Computation of superstring partition function for the non-linear sigma model
on the product of a two-torus and its dual within the scope of the doubled
formalism is presented. We verify that it reproduces the partition functions of
the toroidally compactified type--IIA and type--IIB theories for appropriate
choices of the GSO projection.Comment: 15 page
Giant gravitons in AdS/CFT (I): matrix model and back reaction
In this article we study giant gravitons in the framework of AdS/CFT
correspondence. First, we show how to describe these configurations in the CFT
side using a matrix model. In this picture, giant gravitons are realized as
single excitations high above a Fermi sea, or as deep holes into it. Then, we
give a prescription to define quasi-classical states and we recover the known
classical solution associated to the CFT dual of a giant graviton that grows in
AdS. Second, we use the AdS/CFT dictionary to obtain the supergravity boundary
stress tensor of a general state and to holographically reconstruct the bulk
metric, obtaining the back reaction of space-time. We find that the space-time
response to all the supersymmetric giant graviton states is of the same form,
producing the singular BPS limit of the three charge Reissner-Nordstr\"om-AdS
black holes. While computing the boundary stress tensor, we comment on the
finite counterterm recently introduced by Liu and Sabra, and connect it to a
scheme-dependent conformal anomaly.Comment: 28 pages, JHEP3 class. v2: typos corrected and references adde
Hepatocyte growth factor is upregulated in ischemic retina and contributes to retinal vascular leakage and neovascularization
In patients with macular edema due to ischemic retinopathy, aqueous levels of hepatocyte growth factor (HGF) correlate with edema severity. We tested whether HGF expression and activity in mice with oxygen-induced ischemic retinopathy supports a role in macular edema. In ischemic retina, HGF was increased in endogenous cells and macrophages associated with retinal neovascularization (NV). HGF activator was increased in and around retinal vessels potentially providing vascular targeting. One day after intravitreous injection of HGF, VE-cadherin was reduced and albumin levels in retina and vitreous were significantly increased indicating vascular leakage. Injection of VEGF caused higher levels of vitreous albumin than HGF, and co-injection of both growth factors caused significantly higher levels than either alone. HGF increased the number of macrophages on the retinal surface, which was blocked by anti-c-Met and abrogated in chemokine (C-C motif) ligand 2 (CCL2)−/− mice. Injection of anti-c-Met significantly decreased leakage within 24 hours and after 5 days it reduced retinal NV in mice with ischemic retinopathy, but had no effect on choroidal NV. These data indicate that HGF is a pro-permeability, pro-inflammatory, and pro-angiogenic factor and along with its activator is increased in ischemic retina providing support for a potential role of HGF in macular edema in ischemic retinopathies.Fil: Lorenc, Valeria Erika. Universidad Austral. Facultad de Ciencias Biomédicas. Instituto de Investigaciones en Medicina Traslacional. Consejo Nacional de Investigaciones CientÃficas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones en Medicina Traslacional; Argentina. University Johns Hopkins; Estados UnidosFil: Lima e Silva, Raquel. University Johns Hopkins; Estados UnidosFil: Hackett, Sean F.. University Johns Hopkins; Estados UnidosFil: Fortmann, Seth D.. University Johns Hopkins; Estados UnidosFil: Liu, Yuanyuan. University Johns Hopkins; Estados UnidosFil: Campochiaro, Peter A.. University Johns Hopkins; Estados Unido
Optical properties of low background PEN structural components for the LEGEND-200 experiment
Polyethylene Naphthalate (PEN) plastic scintillator has been identified as
potential self-vetoing structural material in low-background physics
experiments. Scintillating components have been produced radio-pure from PEN
using injection compression molding technology. These low-background PEN
components will be used as active holders to mount the Germanium detectors in
the \legend- neutrinoless double beta decay experiment. In this paper we
present the measurement of the optical properties of these PEN components.
Thus, the emission spectrum, time constant, attenuation and bulk absorption
length as well as light output and light yield are reported. In addition, the
surface of these PEN components has been characterized and an estimation of the
surface roughness is presented. Moreover, the light output of the final
\legend- detector holders has been measured and is reported. These
measurements were used to estimate the self-vetoing efficiency of these
holders
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