Buckling without bending: a new paradigm in morphogenesis

A curious feature of organ and organoid morphogenesis is that in certain cases, spatial oscillations in the thickness of the growing "film" are out-of-phase with the deformation of the slower-growing "substrate," while in other cases, the oscillations are in-phase. The former cannot be explained by elastic bilayer instability, and contradict the notion that there is a universal mechanism by which brains, intestines, teeth, and other organs develop surface wrinkles and folds. Inspired by the microstructure of the embryonic cerebellum, we develop a new model of 2d morphogenesis in which system-spanning elastic fibers endow the organ with a preferred radius, while a separate fiber network resides in the otherwise fluid-like film at the outer edge of the organ and resists thickness gradients thereof. The tendency of the film to uniformly thicken or thin is described via a "growth potential". Several features of cerebellum, +blebbistatin organoid, and retinal fovea morphogenesis, including out-of-phase behavior and a film thickness amplitude that is comparable to the radius amplitude, are readily explained by our simple analytical model, as may be an observed scale-invariance in the number of folds in the cerebellum. We also study a nonlinear variant of the model, propose further biological and bio-inspired applications, and address how our model is and is not unique to the developing nervous system.Comment: version accepted by Physical Review

Sex workers perspectives on strategies to reduce sexual exploitation and HIV risk: a qualitative study in Tijuana, Mexico.

Globally, female sex workers are a population at greatly elevated risk of HIV infection, and the reasons for and context of sex industry involvement have key implications for HIV risk and prevention. Evidence suggests that experiences of sexual exploitation (i.e., forced/coerced sex exchange) contribute to health-related harms. However, public health interventions that address HIV vulnerability and sexual exploitation are lacking. Therefore, the objective of this study was to elicit recommendations for interventions to prevent sexual exploitation and reduce HIV risk from current female sex workers with a history of sexual exploitation or youth sex work. From 2010-2011, we conducted in-depth interviews with sex workers (n = 31) in Tijuana, Mexico who reported having previously experienced sexual exploitation or youth sex work. Participants recommended that interventions aim to (1) reduce susceptibility to sexual exploitation by providing social support and peer-based education; (2) mitigate harms by improving access to HIV prevention resources and psychological support, and reducing gender-based violence; and (3) provide opportunities to exit the sex industry via vocational supports and improved access to effective drug treatment. Structural interventions incorporating these strategies are recommended to reduce susceptibility to sexual exploitation and enhance capacities to prevent HIV infection among marginalized women and girls in Mexico and across international settings

Financial reporting for the Georgia colony

Stewardship reporting was an important tool in the establishment and development of the American Colonies. In 1732 the King of England created the Colony of Georgia as a haven for England\u27s worthy poor. A corporate trust was established to implement this purpose, and it was necessary for the trustees to account for the many private contributions to the cause as well as the grants from the crown. This article discusses the early history of the Georgia colony, presents a thumbnail sketch of Harman Verelst, the Trust\u27s accountant, and illustrates by example the financial reporting he developed for the Georgia Colony

Glance behaviours when using an in-vehicle smart driving aid : a real-world, on-road driving study

In-vehicle information systems (IVIS) are commonplace in modern vehicles, from the initial satellite navigation and in-car infotainment systems, to the more recent driving related Smartphone applications. Investigating how drivers interact with such systems when driving is key to understanding what factors need to be considered in order to minimise distraction and workload issues while maintaining the benefits they provide. This study investigates the glance behaviours of drivers, assessed from video data, when using a smart driving Smartphone application (providing both eco-driving and safety feedback in real-time) in an on-road study over an extended period of time. Findings presented in this paper show that using the in-vehicle smart driving aid during real-world driving resulted in the drivers spending an average of 4.3% of their time looking at the system, at an average of 0.43 s per glance, with no glances of greater than 2 s, and accounting for 11.3% of the total glances made. This allocation of visual resource could be considered to be taken from ‘spare’ glances, defined by this study as to the road, but off-centre. Importantly glances to the mirrors, driving equipment and to the centre of the road did not reduce with the introduction of the IVIS in comparison to a control condition. In conclusion an ergonomically designed in-vehicle smart driving system providing feedback to the driver via an integrated and adaptive interface does not lead to visual distraction, with the task being integrated into normal driving

Automated segmentation and analysis of normal and osteoarthritic knee menisci from magnetic resonance images: data from the Osteoarthritis Initiative

OBJECTIVE: To validate an automatic scheme for the segmentation and quantitative analysis of the medial meniscus (MM) and lateral meniscus (LM) in magnetic resonance (MR) images of the knee