21 research outputs found
A Pipeline for the ROTSE-IIId Archival Data
We have constructed a new, fast, robust and reliable pipeline to detect
variable stars from the ROTSE-IIId archival data. Turkish share of ROTSE-III
archive contains approximately one million objects from a large field of view
(1.85\dgr) and it considerably covers a large portion of northern sky
(\delta>-25\dgr). The unfiltered ROTSE-III magnitude of the objects ranges
from 7.7 to 16.9. The main stages of the new pipeline are as follows: Source
extraction, astrometry of the objects, light curve generation and inhomogeneous
ensemble photometry. A high performance computing (HPC) algorithm has also been
implemented into the pipeline where we had a good performance even on a
personal computer. Running the algorithms of the pipeline on a cluster
decreases analysis time significantly from weeks to hours. The pipeline is
especially tested against long period variable stars with periods of a few
hundred days (e.g Mira and SR) and variables having periods starting from a few
days to a few hundred days were detected.Comment: 8 pages, 5 figures 2 tables; last revision before publishe
Copy number variation and regions of homozygosity analysis in patients with MÜLLERIAN aplasia
An antidote for imazalil-induced genotoxicity in vitro: The lichen, Dermatocarpon intestiniforme (Körber) hasse
Imazalil (IMA), a commonly used fungicide in both agricultural and clinical domains, is suspected to produce serious toxic effects in vertebrates. In recent years, a number of studies have suggested that lichens might be easily accessible sources of natural drugs that could be used as a possible food supplement. Extensive research is being performed to explore the importance of lichen species, which are known to contain a variety of pharmacological active compounds. In this context, the antigenotoxic effect of aqueous Dermatocarpon intestiniforme (Körber) Hasse. extract (DIE) was studied against the genotoxic damage induced by IMA on cultured human lymphocytes (n = 6) using chromosomal aberration (CA) and micronucleus (MN) as cytogenetic endpoints. Human peripheral lymphocytes were treated in vitro with varying concentrations of DIE (0, 25, 50 and 100 μg/ml), tested in combination with IMA (336 μg/ml). DIE alone were not genotoxic and when combined with IMA treatment, it reduced the frequency of CAs and the rate of MNs. A clear dose-dependent decrease in the genotoxic damage of IMA was observed, suggesting a genoprotective role of DIE. The results of the present study suggest that this plant extract per se does not have a genotoxic potential, but can alleviate the genotoxicity of IMA on cultured human lymphocytes. In conclusion our findings may have an important application for the protection of cultured human lymphocyte from the genetic damage and side effects induced by medical and agricultural chemicals hazardous for people
Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
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Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
Additional file 2: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
Table S2. Shows all causative mutations identified in 72 patients from 68 families suffering from primary immunodeficiencies. (XLSX 17 kb
Additional file 4: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
Table S4. (A) The number of patients with isolated or combined infections, and (B) the number of patients with isolated or combined immunophenotypes, and the percentage for which we have reported a genetic diagnosis. (XLSX 11 kb
Additional file 3: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
Table S3. Variants of unknown significance (class 3) and variants in TRAF3 identified in 17 patients suffering from primary immunodeficiencies. (XLSX 11 kb
Additional file 5: of Exome sequencing in routine diagnostics: a generic test for 254 patients with primary immunodeficiencies
Table S5. Quality information of the WES technology, with the mean target coverage, and the % of bases with >â 20Ă coverage. (XLSX 22 kb