Suppression of Implanted MDA-MB 231 Human Breast Cancer Growth in Nude Mice by Dietary Walnut

Walnuts contain components that may slow cancer growth including omega 3 fatty acids, phytosterols, polyphenols, carotenoids, and melatonin. A pilot study was performed to determine whether consumption of walnuts could affect growth of MDA-MB 231 human breast cancers implanted into nude mice. Tumor cells were injected into nude mice that were consuming an AIN-76A diet slightly modified to contain 10% corn oil. After the tumors reached 3 to 5 mm diameter, the diet of one group of mice was changed to include ground walnuts, equivalent to 56 g (2 oz) per day in humans. The tumor growth rate from Day 10, when tumor sizes began to diverge, until the end of the study of the group that consumed walnuts (2.9 ± 1.1 mm3/day; mean ± standard error of the mean) was significantly less (P \u3e 0.05, t-test of the growth rates) than that of the group that did not consume walnuts (14.6 ± 1.3 mm 3 /day). The eicosapentaenoic and docosahexaenoic acid fractions of the livers of the group that consumed walnuts were significantly higher than that of the group that did not consume walnuts. Tumor cell proliferation was decreased, but apoptosis was not altered due to walnut consumption. Further work is merited to investigate applications to cancer in humans

Perancangan Buku Batik Tulis Jarak Arum Ex-lokalisasi Dolly dengan Teknik Watercolor Guna Meningkatkan Brand Awareness

Batik tulis Jarak Arum is one of the unique batik Surabaya from ex-Dolly. Jarak Arum\u27s batik has its own characteristics which is illustrated by the motifs, where the motive is to tell about the ex-Dolly localization earlier known as the second largest in Asia. Through motives contained in batik is expected to lift the image of Dolly earlier known as localization region the second largest in Asia which has now been folded Dolly now exists in name only. With this in mind to improve the image of the previous Dolly to become one of the tourist areas in Surabaya which is famous for its batik is batik tulis Jarak Arum, is expected to change the image of Dolly the better. Batik tulis Jarak Arum also including new products that require media for recognition, in order to be able to become one of the products that can be remembered and recognized by the public. Therefore, this research aims to design book of batik tulis Jarak Arum ex-Dolly with watercolor techniques in order to increase brand awareness. The design of the book batik tulis Jarak Arum ex-Dolly using qualitative data collection methods, namely by interviews, observation, literature study, existing studies and creative brief is very important to define the concept design study. From the analysis of these data, the theme of the design concept obtained is charming. Concepts Charming aims to communicate to the target market, namely the premature adults who are less familiar and interested to be more familiar and batik and recall batik tulis Jarak Arum as part of a product category, with emphasis on product charming character

Translation of findings from laboratory studies of food and alcohol intake into behavior change interventions : the experimental medicine approach.

Objectives: Laboratory studies have contributed important information about the determinants of food and alcohol intake, and they have prompted the development of behavior change interventions that have been evaluated in randomized controlled trials conducted in the field. In this article we apply a recent experimental medicine (EM) framework to this body of research. Method: A conceptual review and focused discussion of the relevant literature is presented. Results: We illustrate how it is possible to translate findings from studies of food and alcohol intake in the laboratory into interventions that are effective for changing behavior in the real world. We go on to demonstrate how systematic failures can occur at different stages within the EM framework, and how these failures ultimately result in interventions that are ineffective for changing behavior. We also consider methodological issues that may constrain the external validity of findings from laboratory studies including demand effects, participant characteristics, and the timing and dose of behavioral interventions. Throughout, we make recommendations to improve the translation of findings from laboratory studies into behavior change interventions that are effective in the field. Conclusions: Consideration of the EM framework will help to ensure that promising candidate interventions for eating and drinking that are identified in laboratory studies can fulfill their translational promise

Believing in food addiction: helpful or counter-productive for eating behaviour?

Objective: Obesity is often attributed to an addiction to food, and many people believe themselves to be “food addicts.” However, little is known about how such beliefs may affect dietary control and weight management. The current research examined the impact of experimentally manipulating participants' personal food addiction beliefs on eating behavior. Methods In two studies, female participants (study 1: N  = 64; study 2: N  = 90) completed food‐related computerized tasks and were given bogus feedback on their performance which indicated that they had high, low, or average food addiction tendencies. Food intake was then assessed in an ad libitum taste test. Dietary concern and time taken to complete the taste test were recorded in study 2. Results: In study 1, participants in the high‐addiction condition consumed fewer calories than those in the low‐addiction condition, F (1,60) = 7.61, P  = 0.008, η p2 = 0.11. Study 2 replicated and extended this finding, showing that the effect of the high‐addiction condition on food intake was mediated by increased dietary concern, which reduced the amount of time participants willingly spent exposed to the foods during the taste test, b  = −0.06 (0.03), 95% confidence interval = −0.13 to −0.01. Conclusions: Believing oneself to be a food addict is associated with short‐term dietary restriction. The longer‐term effects on weight management now warrant attention

Reductions to main meal portion sizes reduce daily energy intake regardless of perceived normality of portion size: a 5 day cross-over laboratory experiment

Background Smaller portions may help to reduce energy intake. However, there may be a limit to the magnitude of the portion size reduction that can be made before consumers respond by increasing intake of other food immediately or at later meals. We tested the theoretical prediction that reductions to portion size would result in a significant reduction to daily energy intake when the resulting portion was visually perceived as ‘normal’ in size, but that a reduction resulting in a ‘smaller than normal’ portion size would cause immediate or later additional eating. Methods Over three 5-day periods, daily energy intake was measured in a controlled laboratory study using a randomized crossover design (N = 30). The served portion size of the main meal component of lunch and dinner was manipulated in three conditions: ‘large-normal’ (747 kcal), ‘small-normal’ (543 kcal), and ‘smaller than normal’ (339 kcal). Perceived ‘normality’ of portion sizes was determined by two pilot studies. Ad libitum daily energy intake from all meals and snacks was measured. Results Daily energy intake in the ‘large-normal’ condition was 2543 kcals. Daily energy intake was significantly lower in the ‘small-normal’ portion size condition (mean difference − 95 kcal/d, 95% CI [− 184, − 6], p = .04); and was also significantly lower in the ‘smaller than normal’ than the ‘small-normal’ condition (mean difference − 210 kcal/d, 95% CI [− 309, − 111], p < .001). Contrary to predictions, there was no evidence that the degree of additional food consumption observed was greater when portions were reduced past the point of appearing normal in size. Conclusions Reductions to the portion size of main-meal foods resulted in significant decreases in daily energy intake. Additional food consumption did not offset this effect, even when portions were reduced to the point that they were no longer perceived as being normal in size. Trial registration Prospectively registered protocol and analysis plan: https://osf.io/natws/; retrospectively registered: https://clinicaltrials.gov/ct2/show/NCT03811210

Visual perceptions of portion size normality and intended food consumption: A norm range model

Smaller portion sizes are associated with lower energy intake. We test a norm range model of the portion size effect on intended intake. A wide range of portion sizes were perceived as normal. Portions perceived as normal did not prompt intended compensatory eating. Portions perceived as smaller than normal prompted intended compensation

Magnetic and Crystallographic Structure of Y₆Mn₂₃D₂₃

The magnetic behavior of Y6Mn23 is dramatically altered upon hydrogenation (or deuteration). In this study it has been found, by means of high-resolution powder diffraction and Rietveld refinement techniques, that the crystallographic structure is distorted from face-centered cubic (Fm3m) at 295 K to a primitive tetragonal structure at 4 K in which deuterium atoms are atomically ordered. Y6Mn23 is a ferromagnetic compound with Tc=486 K, and bulk magnetization of 13.2 Bf.u. (formula unit). After deuteration of Y6Mn23 to the composition Y6Mn23D23, low-temperature scattering data (T\u3c180 K) show that the b and f2 sites in the Fm3m structure are antiferromagnetic and the d and f1 sites have no spontaneous magnetic moment. © 1984 The American Physical Society

A Bose-condensed, simultaneous dual species Mach-Zehnder atom interferometer

This paper presents the first realisation of a simultaneous $^{87}$Rb -$^{85}$Rb Mach-Zehnder atom interferometer with Bose-condensed atoms. A number of ambitious proposals for precise terrestrial and space based tests of the Weak Equivalence Principle rely on such a system. This implementation utilises hybrid magnetic-optical trapping to produce spatially overlapped condensates with a duty cycle of 20s. A horizontal optical waveguide with co-linear Bragg beamsplitters and mirrors is used to simultaneously address both isotopes in the interferometer. We observe a non-linear phase shift on a non-interacting $^{85}$Rb interferometer as a function of interferometer time, $T$, which we show arises from inter-isotope scattering with the co-incident $^{87}$Rb interferometer. A discussion of implications for future experiments is given.Comment: 7 pages, 5 figures. The authors welcome comments and feedback on this manuscrip

Eclogites and basement terrane tectonics in the northern arm of the Grenville orogen, NW Scotland

The presence of eclogites within continental crust is a key indicator of collisional orogenesis. Eclogites within the Eastern Glenelg basement inlier of the Northern Highland Terrane (NHT) have been re-dated in order to provide more accurate constraints on the timing of collision within the northern arm of the Grenville Orogen. The eclog-ites yield dates of ca.1200 Ma which are interpreted to record the onset of continent-continent interaction, and the NHT as a whole is thought to represent the lower plate in successive 1200-1000 Ma collision events. The Eastern Glenelg basement inlier is viewed as a fragment of the leading edge of the NHT continental basement that was partially subducted along a suture and then exhumed back up the subduction channel. Differences in ages of igneous protoliths and intrusive histories, and metamorphic events (this paper) between the NHT basement and the Laurentian foreland, suggests that they were separate crustal blocks until after ca. 1600 Ma. We therefore suggest that: (1) the NHT represents a fragment of Archean-Paleoproterozoic crust that was reworked within the ca. 1.7-1.6 Ga Labradorian-Gothian belt, although whether it was derived from Laurentia or Baltica is uncertain, and (2) amalgamation of the NHT with the Laurentian foreland did not occur until the terminal stages of the Grenville collision at ca. 1000 Ma

A Bright Solitonic Matter-Wave Interferometer

We present the first realisation of a solitonic atom interferometer. A Bose-Einstein condensate of $1\times10^4$ atoms of rubidium-85 is loaded into a horizontal optical waveguide. Through the use of a Feshbach resonance, the $s$-wave scattering length of the $^{85}$Rb atoms is tuned to a small negative value. This attractive atomic interaction then balances the inherent matter-wave dispersion, creating a bright solitonic matter wave. A Mach-Zehnder interferometer is constructed by driving Bragg transitions with the use of an optical lattice co-linear with the waveguide. Matter wave propagation and interferometric fringe visibility are compared across a range of $s$-wave scattering values including repulsive, attractive and non-interacting values. The solitonic matter wave is found to significantly increase fringe visibility even compared with a non-interacting cloud.Comment: 6 pages, 4 figure