Prevalence of inflammatory bowel disease among coeliac disease patients in a Hungarian coeliac centre

BACKGROUND: Celiac disease, Crohn disease and ulcerative colitis are inflammatory disorders of the gastrointestinal tract with some common genetic, immunological and environmental factors involved in their pathogenesis. Several research shown that patients with celiac disease have increased risk of developing inflammatory bowel disease when compared with that of the general population. The aim of this study is to determine the prevalence of inflammatory bowel disease in our celiac patient cohort over a 15-year-long study period. METHODS: To diagnose celiac disease, serological tests were used, and duodenal biopsy samples were taken to determine the degree of mucosal injury. To set up the diagnosis of inflammatory bowel disease, clinical parameters, imaging techniques, colonoscopy histology were applied. DEXA for measuring bone mineral density was performed on every patient. RESULTS: In our material, 8/245 (3,2 %) coeliac disease patients presented inflammatory bowel disease (four males, mean age 37, range 22-67), 6/8 Crohn's disease, and 2/8 ulcerative colitis. In 7/8 patients the diagnosis of coeliac disease was made first and inflammatory bowel disease was identified during follow-up. The average time period during the set-up of the two diagnosis was 10,7 years. Coeliac disease serology was positive in all cases. The distribution of histology results according to Marsh classification: 1/8 M1, 2/8 M2, 3/8 M3a, 2/8 M3b. The distribution according to the Montreal classification: 4/6 Crohn's disease patients are B1, 2/6 Crohn's disease patients are B2, 2/2 ulcerative colitis patients are S2. Normal bone mineral density was detected in 2/8 case, osteopenia in 4/8 and osteoporosis in 2/8 patients. CONCLUSIONS: Within our cohort of patients with coeliac disease, inflammatory bowel disease was significantly more common (3,2 %) than in the general population

Pulmonary Embolism Due To Metal Coil: Case Report

Radiological studies may sometimes reveal unexpected findings. A 42-year-old male patient was referred to our center because of metallic opacities observed on the chest X-ray. Physical examination was unremarkable except for macular lesions on both lower extremities. A detailed medical history revealed that the patient had a varicocele in the right testis which was obliterated with coil embolization 12 years ago. The metallic opacities observed on the chest X-ray were considered to result from the migration of the coils from testis to the lungs. Coil embolization is an effective and safe procedure in the treatment of varicocele. However, as presented in the case, the procedure may cause complications in a certain subgroup of patients. Migration of coils from the varicose testicular veins to the pulmonary vessels may be clinically insignificant; however, when found incidentally, it may pose a diagnostic problem that needs to be solved by the clinician.WoSScopu

Introduction to Hybrid Systems - Yildiz Technical University

IEEE EUROCON Conference -- JUL 01-04, 2013 -- Zagreb, CROATIA -- IEEE, IEEE Croatia Sect, IEEE Reg 8, FEREnergy has always been an important factor for socio-economic development of humans. Most of the energy is generated from fossil fuels in the world. Nevertheless, environmental aspects and depleting of fossil fuels causes increase of renewable energy utilization. The produced energy from renewable energy resources are transferred to grid or used in stand-alone systems. As energy generation depends on environmental conditions, efficiency and energy potential of renewable energy systems changes according to region of installation. In this study, introduction of the solar-wind-battery hybrid system constructed in Davutpasa Campus, Yildiz Technical University, and future work for the system are presented.Yildiz Technical UniversityYildiz Technical University [2012-04-02-KAP04]Authors would like to thank the Yildiz Technical University for full financial support of the project namely Reliability Analysis of Small Scale Hybrid Wind and Solar Energy Systems: A Case Study of Davutpasa Campus, Project No: 2012-04-02-KAP04.WOS:0003431356001672-s2.0-8488863062

Reliability Analysis of Hybrid Energy Systems: Case Study of Davutpasa Campus

IEEE EUROCON Conference -- JUL 01-04, 2013 -- Zagreb, CROATIA -- IEEE, IEEE Croatia Sect, IEEE Reg 8, FERIn recent years, sustainable and clean renewable energy resources are widely used instead of fossil fuel energy resources in electrical energy generation systems. Especially, wind and solar energy conversion systems are utilized together in stand-alone systems. in this study, reliability analysis of a hybrid system installed in Davutpasa Campus of Yildiz Technical University is investigated. The system includes a wind turbine, PV panels, a hybrid charge regulator, a MPNT charge controller, an inverter, battery group and loads. Reliability indexes are calculated for analyzed system. The obtained results are examined and presented in this paper.Yildiz Technical UniversityYildiz Technical University [2012-04-02-KAP04]Authors would like to thank the Yildiz Technical University for full financial support of the project namely Reliability Analysis of Small Scale Hybrid Wind and Solar Energy Systems: A Case Study of Davutpasa Campus, Project No: 2012-04-02-KAP04.WOS:0003431356001662-s2.0-8488861236

A different trauma, a different fracture

Pelvic apophysis avulsion fractures in adolescent athletes are rare injuries and these fractures occur on the growth cartilage on the apophysis plates. Case presentation: A 17-year-old male patient admitted to ED suffering from sharp pain in the right hip and difficulty in walking after kicking ball severely during playing football. On physical examination, there was tenderness in the right thigh consistent with spina iliaca anterior superior (SIAS). Hip movements were within normal range except pain during movement. Neurovascular examination was within normal range. On Pelvic X-ray revealed a crescent shaped avulsion fracture of the right SIAS. The patient was treated conservatively and discharged with recommendations. Discussion and conclusion: The epiphyses and the apophyses are the weakest part of all the skeletal system. In these regions, avulsion fractures may occur with sudden and severe spasm of the muscles. Avulsion fractures of SIAS are mostly treated conservatively unless there is more than 2 cm fragment separated and non-union case in which case surgery is recommended. This type of injuries can be easily overlooked or misdiagnosed due to history of trauma free. It may also effect

Anti-cancer effect of clofazimine as a single agent and in combination with cisplatin on U266 multiple myeloma cell line

Multiple Myeloma (MM) is a malignant neoplasm of bone marrow plasma B cells with high morbidity. Clofazimine (CLF) is an FDA-approved leprostatic, anti-tuberculosis, and anti-inflammatory drug that was previously shown to have growth suppression effect on various cancer types such as hepatocellular, lung, cervix, esophageal, colon, and breast cancer as well as melanoma, neuroblastoma, and leukemia. The objective of this study was to evaluate the anticancer effect and mechanism of CLF on U266 MM cell line. CLF (10 mu M, 24 h) treatment resulted up to 72% growth suppression on a panel of hematological cell lines. Dose-response study conducted on U266 MM cell line revealed an IC50 value of 9.8 +/- 0.7 mu M. CLF also showed a synergistic inhibition effect in combination with cisplatin. In mechanistic assays, CLF treatment caused mitochondrial membrane depolarization, change in cell membrane asymmetry and increase in caspase-3 activity; indicating to an intrinsic apoptosis mechanism. This study provides new evidence for the anticancer effect of CLF on U266 cell line. Further in vivo and clinical studies are warranted to evaluate its therapeutic potential for MM treatment