73 research outputs found
Experimental and numerical investigations in order to model the fire development and propagation for fire safety engineering studie
Adaptive bra designs for the individuals with special needs
Nowadays the numbers of disabled and elderly people is increasing, and the development of adaptive clothing for these people is in demand. The purpose of this study is to add features in bra design, to make it "Easy on, Easy off", to encourage the hemiplegic females to begin to dress themselves and to make dressing easier and more protective for them. This adaptive bra design will offer benefits to the wearer that include independence, conformity to culture, concealment of the disability, comfort, psychological contentment, safety, and durability. Our adaptive bra will promote harmony between functionality and aesthetics. Our e-bra enables continuous, real-time monitoring to identify any pathophysiological changes by monitoring blood pressure, body temperature, respiratory rate, oxygen consumption, some neural activity
Soft capacitor fibers using conductive polymers for electronic textiles
A novel, highly flexible, conductive polymer-based fiber with high electric
capacitance is reported. In its crossection the fiber features a periodic
sequence of hundreds of conductive and isolating plastic layers positioned
around metallic electrodes. The fiber is fabricated using fiber drawing method,
where a multi-material macroscopic preform is drawn into a sub-millimeter
capacitor fiber in a single fabrication step. Several kilometres of fibers can
be obtained from a single preform with fiber diameters ranging between 500um
-1000um. A typical measured capacitance of our fibers is 60-100 nF/m and it is
independent of the fiber diameter. For comparison, a coaxial cable of the
comparable dimensions would have only ~0.06nF/m capacitance. Analysis of the
fiber frequency response shows that in its simplest interrogation mode the
capacitor fiber has a transverse resistance of 5 kOhm/L, which is inversely
proportional to the fiber length L and is independent of the fiber diameter.
Softness of the fiber materials, absence of liquid electrolyte in the fiber
structure, ease of scalability to large production volumes, and high
capacitance of our fibers make them interesting for various smart textile
applications ranging from distributed sensing to energy storage
The in vivo effect of combinations of octylphenol, butylbenzylphthalate and estradiol on liver estradiol receptor modulation and induction of zona radiata proteins in rainbow trout: no evidence of synergy
Calfacilitin is a calcium channel modulator essential for initiation of neural plate development.
Calcium fluxes have been implicated in the specification of the vertebrate embryonic nervous system for some time, but how these fluxes are regulated and how they relate to the rest of the neural induction cascade is unknown. Here we describe Calfacilitin, a transmembrane calcium channel facilitator that increases calcium flux by generating a larger window current and slowing inactivation of the L-type CaV1.2 channel. Calfacilitin binds to this channel and is co-expressed with it in the embryo. Regulation of intracellular calcium by Calfacilitin is required for expression of the neural plate specifiers Geminin and Sox2 and for neural plate formation. Loss-of-function of Calfacilitin can be rescued by ionomycin, which increases intracellular calcium. Our results elucidate the role of calcium fluxes in early neural development and uncover a new factor in the modulation of calcium signalling
Desenvolvimento de bezerros leiteiros alimentados com silagem de leite de transição: I - Trato digestivo
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
The genetic concept of synthetic lethality has now been validated clinically through the demonstrated efficacy of poly(ADP-ribose) polymerase (PARP) inhibitors for the treatment of cancers in individuals with germline loss-of-function mutations in either BRCA1 or BRCA2. Three different PARP inhibitors have now been approved for the treatment of patients with BRCA-mutant ovarian cancer and one for those with BRCA-mutant breast cancer; these agents have also shown promising results in patients with BRCA-mutant prostate cancer. Here, we describe a number of other synthetic lethal interactions that have been discovered in cancer. We discuss some of the underlying principles that might increase the likelihood of clinical efficacy and how new computational and experimental approaches are now facilitating the discovery and validation of synthetic lethal interactions. Finally, we make suggestions on possible future directions and challenges facing researchers in this field
Study of Water Absorption in Raffia vinifera Fibres from Bandjoun, Cameroon
The study is focused on the water diffusion phenomenon through the Raffia vinifera fibre from the stem. The knowledge on the behavior of those fibres in presence of liquid during the realization of biocomposite, is necessary. The parameters like percentage of water gain at the point of saturation, modelling of the kinetic of water absorption, and the effective diffusion coefficient were the main objectives. Along a stem of raffia, twelve zones of sampling were defined. From Fick’s 2nd law of diffusion, a new model was proposed and evaluated compared to four other models at a constant temperature of 23°C. From the proposed model, the effective diffusion coefficient was deduced. The percentage of water gain was in the range of 303–662%. The proposed model fitted better to the experimental data. The estimated diffusion coefficient was evaluated during the initial phase and at the final phase. In any cross section located along the stem of Raffia vinifera, it was found that the effective diffusion coefficient increases from the periphery to the centre during the initial and final phases
Diet modifies elastase I and II activities and mRNA levels during postnatal development and weaning in piglets
International audienc
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