79 research outputs found

    Successful Treatment of Refractory Gastrointestinal Bleeding by Systemic (Oral) Ankaferd Blood Stopper in a Patient with Glanzmann Thrombasthenia.

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    BACKGROUND: Glanzmann Thrombasthenia (GT) is a genetic platelet dysfunction and a life threatening disease. Ankaferd Blood Stopper (ABS) is a topical hemostatic agent of herbal origin which has been recently made available for clinical use. Its hemostatic effect is independent from blood clotting factors and occurs as a result of the aggregation of focal red blood cells by an encapsulated protein web. CASE REPORT: In this paper, a patient with GT is presented in whom 3 months of gastrointestinal bleeding refractory to all medical therapies was controlled within a short time of using oral ABS. CONCLUSION: The difference between this patient and other cases presented in the medical literature is the oral use of ABS. Thus, this patient may contribute to the medical community in showing the safety and efficacy of systemic (oral) ABS in patients with disorders of coagulation. However, there is a need for more patient experiences

    The effect of gradual increment in rhG-CSF dose on stem cell yields in patients with multiple myeloma mobilized with intermediate dose cyclophosphamide plus rhG-CSF.

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    Cyclophosphamide along with recombinant human granulocyte-colony stimulating factor (rhG-CSF) is a commonly used strategy for mobilization. However, the optimal timing for rhG-CSF initiation after cyclophosphamide has not been determined as conclusively as has the G-CSF dose. In this paper, we aimed to present gradual dose increment of rhG-CSF between the third day of mobilization and time to apheresis that is started with 5 μg/kg (from day 3 to day 7) and continued with 10 μg/kg (from day 8 to time to apheresis) for peripheral blood stem cell (PBSC) mobilization in multiple myeloma (MM) patients and its effect on stem cell yield and mobilization success. Data from 30 consecutive patients with MM who underwent PBSC mobilization between October 2011 and June 2013, were retrospectively reviewed. While twenty-eight of 30 patients (93.3%) were successfully mobilized, 2 patients (6.7%) had mobilization failure. The final median CD34+ cell dose harvested from the patients was 9.5×10(6)/kg. The median number of apheresis was 2.5 (range, 0-3). Twenty-four patients (80%) yielded >2×10(6) CD34+ cells/kg in one apheresis procedure. In conclusion, our regimen might be used to decrease the mobilization failure regarding the low dose rhG-CSF use and provide a cost effective strategy

    Development of ceria and tungsten promoted nickel/alumina catalysts for steam reforming of diesel

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    Use of diesel fuel for on-board hydrogen production for auxiliary power units (APUs) through diesel steam reforming (DSR) reaction is a promising route. Coke minimization for cheap and active Ni/Al2O3 catalyst is necessary for long term operation in DSR reaction. Coke minimization with high hydrogen productivity can be accomplished through the optimization of operating conditions and promoting the Ni/Al2O3 catalyst with ceria (CeO2) and tungsten (W) which attracts attention with their coke resistive properties. Maximization of hydrogen production and minimization of coke deposition would require an optimization of operating conditions as well as catalyst content in DSR reaction. It is shown that decrease of GHSV from 25,000 h(-1) to 7500 h(-1) enhances DSR by reducing side product formation, suggesting a mechanism of cracking of longer chain hydrocarbons into C-2-C-3 compounds which are then reformed into the desired products. Side product formation was also reduced at higher steam feeding by further reforming of side products and promotion of water gas shift reaction (WGSR) activity in excess steam environment enhanced H-2 production. CeO2 incorporation lead to formation of CeAlO3 phase which was proven to be effective in promoting WGSR activity, on the other hand W incorporation significantly reduced, even eliminated coke deposition. Hydrogen production capability of Ni-W/Al2O3 catalyst can be improved by using higher steam feeding which enhances WGSR. Long-term operation of DSR reaction for hydrogen production to be used in fuel cell component of APUs can be applied commercially with Ni-W/Al2O3 catalyst

    Primary mesenchymal tumors of the colon: a report of three cases.

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    Primary mesenchymal tumors of the colon are extremely rare tumors among soft tissue sarcomas. These tumors are more aggressive and have poorer prognosis than adenocarcinoma of the colon. Here, we presented 3 cases of primary mesenchymal tumors of the colon. Their histopathological diagnoses are leiomyosarcoma, pleomorphic liposarcoma, and desmoplastic small round cell tumor, respectively. The rarity of primary mesenchymal tumors of the colon makes it difficult to approach the treatment and predict the prognosis of these rare tumors

    Subfoveal Choroidal Thickness Is Associated with Blood Hematocrit Level.

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    PURPOSE: To compare subfoveal choroidal thickness (SFCT), retinal vessel caliber, and ocular pulse amplitude between treated polycythemia vera (PV) patients and healthy adults. METHODS: Forty patients with PV and 40 age- and sex-matched healthy controls were recruited for this cross-sectional study. Spectral-domain optical coherence tomography was used for SFCT and retinal vessel caliber measurements. The Pascal dynamic contour tonometer was used for ocular pulse amplitude measurements. The correlations of blood hematocrit levels with the studied ocular parameters were analyzed. RESULTS: There were no statistically significant differences between the PV patients and controls in SFCT, retinal vessel caliber, and ocular pulse amplitude (p > 0.05). SFCT was associated with hematocrit level in both PV patients and healthy adults (p < 0.05). CONCLUSIONS: Although SFCT, retinal vessel caliber, and ocular pulse amplitude parameters are similar in treated PV patients and healthy controls, SFCT is associated with hematocrit level
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